Abstract

The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.


Claims
Owners (US)

Information currently unavailable.

Download PDF
Document Preview
Document History
  • Publication: May 27, 2008
  • Application: May 15, 2007
    US US 74899207 A
  • Priority: May 15, 2007
    US US 74899207 A
  • Priority: May 5, 2004
    US US 49272904 A
  • Priority: Oct 16, 2002
    US US 0233165 W
  • Priority: Oct 16, 2001
    US US 32970901 P

Download Citation


Sign in to the Lens

Feedback