Methods And Kits For Diagnosis And/or Prognosis Of The Tolerant State In Liver Transplantation


The long-term survival of transplanted grafts critically depends on the life-long administration of immunosuppressive drugs to prevent graft rejection. These drugs are very effective at preventing graft rejection, but they are also associated with severe side effects. Inventors have selected a set of genes whose expression characterizes the tolerant state in liver transplantation in humans. Based on the expression level profile of this set of genes, inventors provide a non-invasive method to assess diagnosis and/or prognosis of the tolerant state in liver transplantation in humans, and kits to perform it. These kits are simpler and cheaper than others based on a great number of genes, such as commercial microarrays with thousands of probes.

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Document History
  • Publication: Jul 10, 2008
  • Application: Jan 4, 2008
    WO EP 2008050057 W
  • Priority: Jan 4, 2007
    ES ES 200700073 A

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