Compositions And Methods For Immunomodulation In An Organism


The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

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Document History
  • Publication: May 15, 2018
  • Application: May 17, 2016
    US US 201615156618 A
  • Priority: May 17, 2016
    US US 201615156618 A
  • Priority: Dec 11, 2014
    US US 201414567317 A
  • Priority: Feb 8, 2012
    US US 201213368605 A
  • Priority: May 17, 2006
    US US 43549706 A
  • Priority: May 17, 2005
    US US 68166305 P

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