Systems And Methods For Using Paired-end Data In Directed Acyclic Structure


Methods of analyzing a transcriptome that involves obtaining at least one pair of paired-end reads from a transcriptome from an organism, finding an alignment with an optimal score between a first read of the pair and a node in a directed acyclic data structure (the data structure has nodes representing RNA sequences such as exons or transcripts and edges connecting pairs of nodes), identifying candidate paths that include the node connected to a downstream node by a path having a length substantially similar to an insert length of the pair of paired-end reads, and aligning the paired-end rends to the candidate paths to determine an optimal-scoring alignment.

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Document History
  • Publication: Aug 21, 2018
  • Application: Jul 14, 2015
    US US 201514798686 A
  • Priority: Jul 14, 2015
    US US 201514798686 A
  • Priority: Jan 17, 2014
    US US 201414157979 A
  • Priority: Oct 21, 2013
    US US 201361893467 P

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