Novel Aminopyrimidine Derivatives As Plk1 Inhibitors

Abstract

The present invention relates to a compound represented by Formula [I]: or a pharmaceutically acceptable salt or ester thereof, wherein R<SUB>1 </SUB>and R<SUB>2</SUB>, which may be the same or different, are each a hydrogen atom, a halogen atom, a lower alkyl group which may be substituted, or a cyclopropyl group; R<SUB>3</SUB> and R<SUB>4</SUB>, which may be the same or different, are each a hydrogen atom, a lower alkyl group substituted with NR<SUB>a</SUB>R<SUB>b</SUB>, a 4- to 6-membered aliphatic heterocyclic group, a lower alkyl group substituted with a 4- to 6-membered aliphatic heterocyclic group, a 5- or 6-membered aromatic heterocyclic group, or a lower alkyl group substituted with a 5- or 6-membered aromatic heterocyclic group; and R<SUB>5</SUB> is a hydrogen atom, a cyano group, a halogen atom, or a lower alkyl group.


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Document History
  • Publication: Jul 10, 2008
  • Application: Dec 20, 2007
    WO JP 2007075224 W
  • Priority: Oct 11, 2007
    JP 2007265783 A
  • Priority: Dec 28, 2006
    JP 2006356575 A

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