Substituted Isoxazoles For Treating Cancer

Abstract

The present disclosure provides substituted cyclohexylamine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.


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Document History
  • Publication: Oct 23, 2018
  • Application: Sep 9, 2015
    US US 201515510605 A
  • Priority: Sep 9, 2015
    US US 201515510605 A
  • Priority: Sep 9, 2015
    US US 2015/0049217 W
  • Priority: Sep 10, 2014
    US US 201462048756 P

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