Adenosine Receptor Agonists, Partial Agonists, And Antagonists

Abstract

Disclosed are A3 adenosine receptor antagonists and/or partial agonists and A1 adenosine receptor agonists and/or partial agonists of formula (I): wherein R1 to R5 are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The A3 AR antagonists or partial agonists find use in treating a number of diseases such as cancer, glaucoma, and inflammatory diseases, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled compounds of formula (I) and the use thereof in diagnostic imaging of tissues and organs. The A1 AR agonists and partial agonists find use in treating diseases such as seizures, convulsion, stroke, diabetes, pain, arrhythmias, depression, and anxiety and in cardioprotection or neuroprotection.


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Document History
  • Publication: Nov 10, 2015
  • Application: May 24, 2012
    US US 201213479973 A
  • Priority: May 24, 2012
    US US 201213479973 A
  • Priority: Mar 18, 2011
    US US 201113056997 A
  • Priority: Jul 31, 2009
    US US 2009/0052439 W
  • Priority: Jul 31, 2009
    US US 5243909 A
  • Priority: Aug 1, 2008
    US US 8558808 P

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