Phosphoinositide 3-kinase Inhibitor Compounds And Methods Of Use

  • Published: Jun 19, 2008
  • Earliest Priority: Dec 07 2006
  • Family: 30
  • Cited Works: 0
  • Cited by: 69
  • Cites: 0
  • Additional Info: Full text
Abstract

Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R<SUP>3</SUP> is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. Formula (Ic) and (Id).


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