Decoy Peptides Inhibiting Protein Phosphatase 1-mediated Dephosphorylation Of Phospholamban

  • Published: Jan 9, 2014
  • Earliest Priority: Jul 05 2012
  • Family: 11
  • Cited Works: 62
  • Cited by: 0
  • Cites: 4
  • Additional Info: Cited Works Published

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The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.


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Document History
  • Publication: Jan 9, 2014
  • Application: Jul 5, 2013
    WO KR 2013006009 W
  • Priority: Jul 5, 2012
    US US 201261668034 P

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