Decoy Peptides Inhibiting Protein Phosphatase 1-mediated Dephosphorylation Of Phospholamban

  • Published: Jan 9, 2014
  • Earliest Priority: Jul 05 2012
  • Family: 11
  • Cited Works: 62
  • Cited by: 0
  • Cites: 4
  • Additional Info: Cited Works Published
Full-text?

The full document isn't yet available to us from the patent office.

Abstract

The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.


Claims

Information currently unavailable.

Download PDF
Document Preview
Document History
  • Publication: Jan 9, 2014
  • Application: Jul 5, 2013
    WO KR 2013006009 W
  • Priority: Jul 5, 2012
    US US 201261668034 P

Download Citation


Sign in to the Lens

Feedback