{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"006-847-447-584-754","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"006-847-447-584-754"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11756,"type":"PATENT","title":"Claude Bernard University Lyon 1 Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3345,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8395,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Claude Bernard uni*; uni* lyon 1. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2843
Search Applicants and Owners separately: Claude Bernard uni*; uni* lyon 1. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2843
by replacement\n\nwherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, wherein the sequence of said wild-type PIV-5 F protein comprises or consists of:\nof the amino acid which, in the sequence of said wild-type PIV-5 F protein, is in position 22, and\nof the amino acid which, in the sequence of said wild-type PIV-5 F protein, is in position 132, and\nof the amino acid which, in the sequence of said wild-type PIV-5 F protein, is in position 290, and\nof the amino acid which, in the sequence of said wild-type PIV-5 F protein, is in position 449,\n
i. the sequence of SEQ ID NO: 31, or\n
ii. the sequence, which is identical to the sequence of SEQ ID NO: 31 except for the amino acid at position 443, which is S instead of P, or\n
iii. a sequence, which is of the same amino acid length as said sequence of i. or ii. and which is more than 95% identical to said sequence of i. or ii., but which does not simultaneously comprise the amino acids P, E, A and P at positions 22, 132, 290 and 449, respectively,\n
wherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, wherein said wild-type PIV-5 F protein comprises or consists of\n
i. the sequence of SEQ ID NO: 31, or\n
ii. the sequence, which is identical to the sequence of SEQ ID NO: 31 except for the amino acid at position 443, which is S instead of P, or\n
iii. the sequence of SEQ ID NO: 35."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, which comprises or is the sequence of SEQ ID NO: 65."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, the amino acid sequence of which comprises a sequence, which is derivable from said wild-type PIV 5 protein by the amino acid replacements indicated in claim 1 and, which is further derivable from that of said wild-type PIV 5 protein by substitution of the native cleavage site of said F protein by another enzymatic cleavage site, and/or by insertion into said F protein of an enzymatic cleavage site other than the native cleavage site of this F protein, and/or by deletion of a C-terminal portion of said F protein, said C-terminal portion extending in the N-terminal direction from the last amino acid at the C-terminal end of the protein, but without extending beyond the HR2 domain of said F protein."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 5, wherein said cleavage site other than the native cleavage site is a tissue-specific cleavage site."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["An isolated cell, which comprises at least one mutant protein of claim 1."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["An isolated immune system cell, which expresses at its surface at least one mutant protein of claim 1."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["An isolated cell of the human or non-human animal immune system, wherein said cell expresses at its surface at least one mutant protein of claim 1."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising at least one mutant protein of claim 1 or 4."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["An isolated tumor cell, comprising at least one mutant protein of claim 1."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A hybridoma, which comprises at least one mutant protein of claim 1."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["An isolated stem or progenitor cell, having a capacity for differentiation into muscle cell, wherein said cell comprises at least one mutant protein of claim 1, said cell not being a human embryo cell."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, wherein the sequence of said wild-type PIV-5 F protein consists of\n
i. the sequence of SEQ ID NO: 31, or\n
ii. the sequence, which is identical to the sequence of SEQ ID NO: 31 except for the amino acid in position 443, which is S instead of P, or\n
iii. a sequence, which is:\n\nwhich is identical in size to that of SEQ ID NO: 31, or of a size larger than that of SEQ ID NO: 31 by a maximum of 7 C-terminal amino acids, or of a size smaller than that of SEQ ID NO: 31 by a maximum of 7 C-terminal amino acids, and\nwhich is more than 95% identical to said sequence of i. or ii., this identity percentage being calculated over the length of said sequence of i. or ii. respectively, but\nwhich does not simultaneously comprise the amino acids P, E, A and P at positions 22, 132, 290 and 449, respectively,\n
wherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein according to any one of claims 2, 3 and 14, the amino acid sequence of which comprises a sequence, which is derivable from said wild-type PIV-5 F protein by the amino acid replacements indicated in claim 1 and, which is further derivable from said wild-type PIV-5 F protein sequence by\n
at least one mutation selected from the group consisting of\n\nand by\nthe replacement of the amino acid in position 49 by the amino acid A,\nthe replacement of the amino acid in position 402 by the amino acid A,\nthe replacement of the amino acid in position 443 by the amino acid P, and\nthe replacement of the amino acid in position 447 by the amino acid P,\n
at least one mutation selected from the group consisting of\n\nwherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of any one of claims 2, 3 and 14, the amino acid sequence of which comprises a sequence, which is derivable from said wild-type PIV-5 F protein by the amino acid replacements indicated in claim 1 and, which is further derivable from said wild-type PIV-5 F protein sequence by\nthe replacement of the amino acid in position 147 by V, I or L,\nthe replacement of the amino acid in position 158 by V, I or L, and\nthe replacement of the amino acid in position 463 by V, I or L,\n
at least one mutation selected from the group consisting of\n\nand/or by\nthe replacement of the amino acid in position 49 by the amino acid A,\nthe replacement of the amino acid in position 402 by the amino acid A,\nthe replacement of the amino acid in position 443 by the amino acid P, and\nthe replacement of the amino acid in position 447 by the amino acid P,\n
at least one mutation selected from the group consisting of\n\nwherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 16, wherein said hydrophobic amino acid is V, I or L."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of any one of claims 2, 3 and 14, the amino acid sequence of which comprises a sequence, which is derivable from said wild-type PIV-5 F protein by the amino acid replacements indicated in claim 1 and, which is further derivable from said wild-type PIV-5 F protein sequence by\nthe replacement of the amino acid in position 147 by a hydrophobic amino acid,\nthe replacement of the amino acid in position 158 by a hydrophobic amino acid, and\nthe replacement of the amino acid in position 463 by a hydrophobic amino acid,\n
at least one mutation selected from the group consisting of\n\nand by\nthe replacement of the amino acid in position 147 by a hydrophobic amino acid, and\nthe replacement of the amino acid in position 158 by a hydrophobic amino acid,\n
the replacement of the amino acid in position 463 by a hydrophobic amino acid, wherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of any one of claims 2, 3 and 14, the amino acid sequence of which comprises a sequence, which is derivable from said wild-type PIV-5 F protein by the amino acid replacements indicated in claim 1 and, which is further derivable from said wild-type PIV-5 F protein sequence by\n
the replacement of the amino acid in position 147 by a hydrophobic amino acid, and by\n
the replacement of the amino acid in position 158 by a hydrophobic amino acid,\nwherein said positions are computed by alignment with respect to the reference wild-type PIV-5 F protein of SEQ ID NO: 31."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 16, wherein said hydrophobic amino acid is I or L."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 16, wherein said hydrophobic amino acid is V."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 18, wherein said hydrophobic amino acid is V, I or L."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 18, wherein said hydrophobic amino acid is V."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The isolated cell of claim 7, which is a placental cell."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The isolated tumor cell of claim 11, which is a myeloma cell."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The isolated tumor cell of claim 11, wherein said at least one mutant protein of claim 1 is surface-expressed."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The isolated immune system cell of claim 8, which is an isolated dendritic cell."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising at least one isolated immune system cell of claim 8 and/or at least one isolated cell of claim 9."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The isolated stem or progenitor cell of claim 13, wherein said at least one mutant protein of claim 1 is surface-expressed."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The mutant protein of claim 1, which is a fusogenic protein."],"number":30,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}