Compositions And Methods Involving Regulation Of Mammalian Circadian Rhythms


The invention provides compositions comprising isolated BMAL1 protein and isolated CLOCK protein; isolated BMAL1 protein, isolated CLOCK protein and further comprising isolated PER protein and (optionally) isolated TIM protein; BMAL1/CLOCK-dependent assays for identifying modulators of period gene expression; and methods of diagnosing disorders which are linked to an abnormality of the circadian clock.


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