Fabrication Of Vascularized Tissue Using Microfabricated Two-dimensional Molds

Abstract

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.


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Document History
  • Publication: Feb 4, 2014
  • Application: May 24, 2010
    US US 78586510 A
  • Priority: May 24, 2010
    US US 78586510 A
  • Priority: Jun 28, 2002
    US US 18724702 A
  • Priority: Mar 25, 2002
    US US 36767502 P
  • Priority: Apr 28, 2000
    US US 56048000 A
  • Priority: Nov 12, 1999
    US US 16532999 P
  • Priority: Apr 30, 1999
    US US 13193099 P

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