{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"005-157-689-461-007","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"005-157-689-461-007"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10784,"type":"PATENT","title":"Purdue University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8254,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Purdue Uni*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 467
Search Applicants and Owners separately: \"Purdue Uni*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 467
a) obtaining two or more sample glycopeptides or glycoproteins from the subject;\n
b) obtaining two or more reference glycopeptides or glycoproteins;\n
c) comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins using mass spectrometry; and\n
d) detecting a difference in a glycosylation state between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins;\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins comprises using isotopically labeled internal standard peptides."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins comprises using global isotopic coding of glycopeptides or glycoproteins."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins comprises using liquid chromatography and absorbance or fluorescence."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins comprises immunological assaying of biomarkers from test subjects and disease-free subjects."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where the glycosylation state is due to at least one of fucosylation, sialylation, glucosylation, galactosylation, N-acetyl galactosylation, N-acetyl glucosylation, or mannosylation."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 further comprising affinity selecting the glycopeptides or glycoproteins using lectin."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 further comprising affinity selecting the glycopeptides or glycoproteins using antibodies."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where the disease is cancer."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A method for detecting the presence, absence, progression, regression, or extent of a disease or disorder in a subject, comprising:\nwherein a difference in the glycosylation state between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins is indicative of the presence, absence, progression, regression, or extent of the disease or disorder.\n
a) obtaining two or more sample glycopeptides or glycoproteins from the subject;\n
b) obtaining two or more reference glycopeptides or glycoproteins;\n
c) comparing the sample glycopeptides or glycoproteins with the reference glycopeptides or glycoproteins using mass spectrometry; and\n
d) detecting a difference in concentration between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins;\n"],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 where the difference in the concentration of glycopeptides or glycoproteins is due to a change in glycopeptide or glycoprotein mass."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 where the change in concentration of glycopeptides or glycoproteins is due to a change in the amount of fucose, sialic acid, glucose, galactose, mannose, N-acetylgalactosamine, N-acetylglucosamine, Lewis antigen, or N-linked 13(1,6)-branching in the glycan portion of the glycoconjugate."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 where the change in concentration of glycopeptides or glycoproteins is due to fucosylation."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 where the change in the concentration of glycopeptides or glycoproteins is due to an antigenic glycan."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 where the change in concentration of glycopeptides or glycoproteins is due to a Lewis antigen."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of diagnosing a disease which comprises the steps of:\nwherein a difference in concentration between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins is indicative of the presence, absence, progression, regression, or extent of the disease or disorder.\n
a) providing a sample which comprises at least two glycopeptides or glycoproteins;\n
b) providing a reference which comprises at least two glycopeptides or glycoproteins; and\n
c) comparing the concentration of the sample glycopeptides or glycoproteins with the concentration of the reference glycopeptides or glycoproteins using mass spectrometry;\n"],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 where the difference in the concentration of glycopeptides or glycoproteins comprises determining changes in glycopeptide or glycoprotein mass."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 further comprising affinity selecting the glycopeptides or glycoproteins using a lectin or an antibody."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 where comparing the concentration of the sample glycopeptides or glycoproteins with the concentration of the reference glycopeptides or glycoproteins comprises detecting changes in the concentration of at least one glycopeptide or glycoprotein."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 where comparing the concentration of the sample glycopeptides or glycoproteins with the concentration of the reference glycopeptides or glycoproteins comprises detecting a change in the amount of fucose, sialic acid, glucose, galactose, mannose, N-acetylgalactosamine, Nacetylglucosamine, Lewis antigen, or N-linked 13(1,6)-branching in the glycan portion of the glycopeptides or glycoproteins."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 where comparing the concentration of the sample glycopeptides or glycoproteins with the concentration of the reference glycopeptides or glycoproteins comprises detecting changes in fucosylation of the glycopeptides or glycoproteins."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 16 where the disease is cancer."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["A method of diagnosing a disease which comprises the steps of:\nwherein a difference in the concentration between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins is an indicator of the disease.\n
a) providing a sample which comprises at least two glycopeptides or glycoproteins;\n
b) providing a reference which comprises at least two glycopeptides or glycoproteins; and\n
c) comparing the mass of the sample glycopeptides or glycoproteins with the mass of the reference glycopeptides or glycoproteins using mass spectrometry;\n"],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 wherein the difference in the concentration of glycopeptides or glycoproteins is due to a change in concentration of the peptide or protein portions of the glycopeptides or glycoproteins."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 10 wherein the glycans are removed from the glycopeptides or glycoproteins before comparing them using mass spectroscopy."],"number":25,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}wherein a difference in the mass between the sample glycopeptides or glycoproteins and the reference glycopeptides or glycoproteins is an indicator of the disease.\n