Antigenic Peptide Of Hsv-2 And Methods For Using Same


The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

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Document History
  • Publication: Jun 2, 2015
  • Application: Apr 3, 2010
    US US 201013262833 A
  • Priority: Apr 3, 2010
    US US 201013262833 A
  • Priority: Apr 3, 2010
    US US 2010/0029880 W
  • Priority: Jul 24, 2009
    US US 22848909 P
  • Priority: Apr 3, 2009
    US US 16663709 P

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