{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"003-783-735-522-495","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"003-783-735-522-495"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11868,"type":"PATENT","title":"University of South Carolina - Columbia Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":6717,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8472,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
Search Applicants and Owners separately:Wake Forest Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2294
(a) a flagellin adjuvant comprising:(i) a flagellin N-terminal constant region; and(ii) a flagellin C-terminal constant region; and
(b) a tumor antigen between the N-terminal constant region and the C-terminal constant region; andwherein the flagellin N-terniinal constant region and/or the flagellin C-terminal constant region of the flagellin adjuvant comprises a TLR5 recognition site and the isolated fusion protein is able to activate the TLR5 pathway."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the flagellin adjuvant comprises a deleted flagellin hypervariable region or the flagellin hypervariable region is absent from the flagellin adjuvant."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the tumor antigen is inserted (i) within the hypervariable region, (ii) between the flagellin N-terminal constant region and the hypervariable region, or (iii) between the flagellin C-terminal constant region and the hypervariable region."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the tumor antigen is a breast tumor antigen."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the tumor antigen comprises Fra-1 and/or HER2."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the tumor antigen is a cancer/testis antigen."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of claim 1, wherein the tumor antigen comprises a a MAGE antigen, a GAGE antigen and/or NY-ESO-1."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A nucleic acid encoding the fusion protein of claim 1."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A vector comprising the nucleic acid of claim 8."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A host cell comprising the nucleic acid of claim 8 or the vector of claim 9."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A method of making the fusion protein of claim 1, the method comprising culturing the host cell of claim 10 in a culture medium under conditions sufficient for the fusion protein to be produced."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein the fusion protein is collected from the host cell or from the culture medium."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["An immunogenic composition comprising the fusion protein of claim 1 in a pharmaceutically acceptable carrier."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["Use of the fusion protein of any of claims 1 to 7 or the immunogenic composition of claim 13 in the manufacture of a medicament to produce an immune response in a mammalian subject against the tumor antigen."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of any of claims 1 - 7 or the immunogenic composition of claim 13, for use in producing an immune response in a mammalian subject against the tumor antigen."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["Use of the fusion protein of any of claims 1 to 7 or the immunogenic composition of claim 13 in the manufacture of a medicament to treat a tumor in a mammalian subject."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The fusion protein of any of claims 1 - 7 or the immunogenic composition of claim 13, for use in treating a tumor in a mammalian subject."],"number":17,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}