{"search_session":{},"preferences":{"l":"fr","queryLanguage":"fr"},"patentId":"001-416-074-495-399","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"001-416-074-495-399"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11720,"type":"PATENT","title":"University of Iowa - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3930,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8373,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Search Applicants and Owners separately: uni* iowa
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Add to collection. Total patents: 3686
(a) contacting the compound with a cell or cellular extract, which expresses an FKHL7 gene product having the amino acid sequence of SEQ ID NO:2; and
(b) determining the resulting FKHL7 DNA-binding activity,
wherein an increase or decrease in the FKHL7 DNA-binding activity in the presence of the compound as compared to the DNA-binding activity in the absence of the compound indicates that the compound is a modulator of FKHL7 DNA-binding activity."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the compound is an agonist of an FKHL7 DNA-binding activity."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the compound is an antagonist of an FKHL7 DNA-binding activity."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 , wherein the compound is selected from the group consisting of a polypeptide, a nucleic acid, a peptidomimetic, and a small molecule."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4 , wherein the small molecule is a steroid."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4 , wherein the nucleic acid is a member selected from the group consisting of a gene replacement, an antisense, a ribozyme, and a triplex nucleic acid."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method for identifying a compound that modulates FKHL7 DNA-binding activity comprising the steps of:
(a) combining an FKHL7 protein having the amino acid sequence of SEQ ID NO:2, and FKHL7 binding partner, and a test compound under conditions wherein, but for the test compound, the FKHL7 protein and FKHL7 binding partner are able to interact; and
(b) detecting the formation of an FKHL7 protein/FKH7 binding partner complex,such that a difference in the formation of an FKHL7 protein/FKHL7 binding partner complex in the presence of a test compound relative to in the absence of the test compound indicates that the test compound is a modulator of FKHL7 DNA-binding activity."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 , wherein the test compound is selected from the group comprising a polypeptide, a nucleic acid, a peptidomimetic, and a small molecule."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein the small molecule is a steroid."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 , wherein the nucleic acid is a member selected from the group consisting of a gene replacement, an antisense, a ribozyme, and a triplex nucleic acid."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 , wherein the test compound is an agonist of on FKHL7 DNA-binding activity."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7 , wherein the test compound is an antagonist of on FKHL7 DNA-binding activity."],"number":12,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}