{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"197-348-112-582-968","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"197-348-112-582-968"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10731,"type":"PATENT","title":"The University of North Carolina at Chapel Hill - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8887,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8232,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
(a) a promoter operatively linked to the nucleic acid encoding miR-206; and\n
(b) a transcription termination sequence."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the promoter is a tissue-specific promoter."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the tissue-specific promoter is a muscle creatine kinase promoter."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 7, wherein the vector is a viral vector."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein the viral vector is a retrovirus vector."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein the viral vector is an adenovirus vector."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a mammal."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A method for increasing myocyte differentiation or inhibiting myocyte proliferation comprising contacting a skeletal muscle progenitor cell in vitro with an isolated nucleic acid encoding miR-206."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein miR-206 comprises a nucleotide sequence of SEQ ID NO: 3 or a sequence at least 70% identical to SEQ ID NO: 3."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the isolated nucleic acid is a miR-206 precursor molecule."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the nucleic acid is present in a vector."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the vector comprises:\n
(a) a promoter operatively linked to the nucleic acid encoding miR-206; and\n
(b) a transcription termination sequence."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 19, wherein the promoter is a tissue-specific promoter."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 19, wherein the tissue-specific promoter is a muscle creatine kinase promoter."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the vector is a viral vector."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 22, wherein the viral vector is a retrovirus vector."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 22, wherein the viral vector is an adenovirus vector."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the skeletal muscle progenitor cell is a satellite cell."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein Pax7 expression is reduced in the skeletal muscle progenitor cell following contact with the isolated nucleic acid encoding miR-206."],"number":26,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}