{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"196-748-737-301-747","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"196-748-737-301-747","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12134,"type":"PATENT","title":"The University of Tokushima Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1153,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8639,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Univ* Tokushima. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1153
Search Applicants and Owners separately:Univ* Tokushima. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1153
(a) bringing an endoplasmic reticulum stressor candidate substance into contact with the transformant of claim 6;\n
(b) measuring the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor candidate substance, and comparing the measured fluorescence intensity with the fluorescence intensity of a control transformant not in contact with the endoplasmic reticulum stressor candidate substance; and\n
(c) selecting the endoplasmic reticulum stressor candidate substance as an endoplasmic reticulum stressor when the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor candidate substance is higher than the fluorescence intensity of the control transformant."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 8, wherein the endoplasmic reticulum stressor is an endoplasmic reticulum stressor that activates ATF6 pathway, but does not activate IRE1α pathway or PERK pathway; or an endoplasmic reticulum stressor that activates ATF6 pathway, and IRE1α pathway and/or PERK pathway."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A method for screening an endoplasmic reticulum stress inhibitor, comprising the steps of:\n
(d) bringing an endoplasmic reticulum stressor and a test substance with the transformant of claim 6;\n
(e) measuring the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor and the test substance, and comparing the measured fluorescence intensity with the fluorescence intensity of a control transformant that is not in contact with the test substance but in contact with the endoplasmic reticulum stressor; and\n
(f) selecting the test substance as an endoplasmic reticulum stress inhibitor when the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor and the test substance is higher than the fluorescence intensity of the control transformant."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method for screening an antidiabetic drug candidate, comprising the steps of:\n
(g) bringing an endoplasmic reticulum stressor and a test substance with the transformant of claim 7;\n
(h) measuring the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor and the test substance, and comparing the measured fluorescence intensity with the fluorescence intensity of a control transformant that is not in contact with the test substance but in contact with the endoplasmic reticulum stressor; and\n
(i) selecting the test substance as an antidiabetic drug candidate when the fluorescence intensity of the transformant in contact with the endoplasmic reticulum stressor and the test substance is higher than the fluorescence intensity of the control transformant."],"number":11,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}