{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"191-482-566-312-670","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"191-482-566-312-670"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11789,"type":"PATENT","title":"Newcastle University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":9350,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8422,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: Newcastle Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1333
Search Applicants and Owners separately: Newcastle Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1333
a) contacting the surface with an aqueous solution comprising (i) a lipase; and (ii) a bleach component and (iii) optional detergent adjunct;
b) rinsing and drying the textile or hard surface;characterized in that the lipase has improved stability to oxidative degradation compared to the mature polypeptide of SEQ ID NO:1 and lipase activity."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["A method of cleaning a textile or hard surface or other surface in fabric and home care comprising the steps of:
a) contacting the surface with an aqueous solution comprising (i) a lipase; and (ii) a bleach component and (iii) optional detergent adjunct;
b) rinsing and drying the textile or hard surface;characterized in that the lipase comprises a lipase variant comprising a substitution at one or more of the positions selected from the group of positions corresponding to T37, N39 and G91, of the mature polypeptide of SEQ ID NO:1, wherein the variant has lipase activity."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["A method of manufacturing a detergent composition comprising a lipase exhibiting improved stability to oxidative degradation, comprising the step of mixing a lipase variant having improved stability to oxidative degradation compared to the mature polypeptide of SEQ ID NO:1 and wherein the variant has lipase activity, preferably comprising a substitution at one or more of the positions selected from the group of positions corresponding to T37, N39 and G91 of the mature polypeptide of SEQ ID NO:1, with a detergent adjunct."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A method according to any preceding claim wherein the lipase exhibits improved stability to oxidative degradation in the presence of a compound of Formula 2: in which R1 is 2-butyloctyl, according to the Test defined in Example 1 herein."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 3 or claim 4 wherein the lipase is mixed with a bleach component."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 1, 2 or claim 5 wherein the bleach component comprises a bleach catalyst that is capable of accepting an oxygen atom from a peroxyacid and transferring the oxygen atom to an oxidizeable substrate and (ii) a diacyl and/or tetraacyl peroxide species, preferably a bleach catalyst comprising an iminium and/or carbonyl functional group, most preferably an oxazidinium and/or dioxirane functional group, and/or is capable of forming an oxaziridinium and/or a dioxirane functional group upon acceptance of an oxygen atom."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method according to claim 5 wherein the bleach catalyst has a chemical structure corresponding to the chemical formula: wherein: n and m are independently from 0 to 4; each R1 is independently selected from a substituted or unsubstituted radical selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, fused aryl, heterocyclic ring, fused heterocyclic ring, nitro, halo, cyano, sulphonato, alkoxy, keto, carboxylic, and carboalkoxy radicals, and any two vicinal R1 substituents may combine to form a fused aryl, fused carbocyclic or fused heterocyclic ring; each R2 is independently selected from a substituted or unsubstituted radical independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkaryl, aryl, aralkyl, alkylenes, heterocyclic ring, alkoxy, arylcarbonyl groups, carboxyalkyl groups and amide groups; any R2 may be joined together with any other of R2 to form part of a common ring; any geminal R2 may combine to form a carbonyl; and wherein any two R2 may combine to form a substituted or unsubstituted fused unsaturated moiety; R3 is a C1 to C20 substituted or unsubstituted alkyl; R4 is hydrogen or the moiety Qt-A, wherein: Q is a branched or unbranched alkylene, t = 0 or 1, and A is an anionic group selected from the group consisting of OSO3-, SO3-, CO2-, OCO2-, OPO32-, OPO3H- and OPO2-; R5 is hydrogen or the moiety -CR11R12-Y-Gb-Yc-[(CR9R10)y-O]k-R8, wherein: each Y is independently selected from the group consisting of O, S, N-H, or N-R8; and each R8 is independently selected from the group consisting of alkyl, aryl and heteroaryl, said moieties being substituted or unsubstituted, and whether substituted or unsubsituted said moieties having less than 21 carbons; each G is independently selected from the group consisting of CO, SO2, SO, PO and PO2; R9 and R10 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; R11 and R12 are independently selected from the group consisting of hydrogen and alkyl, or when taken together may join to form a carbonyl; b = 0 or 1; c can = 0 or 1, but c must = 0 if b = 0; y is an integer of from 1 to 6; k is an integer of from 0 to 20; R6 is H, or an alkyl, aryl or heteroaryl moiety; said moieties being substituted or unsubstituted; and X, if present, is a suitable charge balancing counterion, preferably the bleach catalyst has a chemical structure corresponding to the chemical formula: wherein R13 is a branched alkyl group containing from 3 to 24 carbons, or a linear alkyl group containing from 1 to 24 carbons, most preferably wherein R13 is selected from the group consisting of 2-butyloctyl, 2-pentylnonyl, 2-hexyldecyl, iso-tridecyl and iso-pentadecyl."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A method according to any preceding claim wherein the parent lipase comprises an amino acid sequence with at least 60% identity with the mature polypeptide of SEQ ID NO: 1; consists of the amino acid sequence of the mature polypeptide of SEQ ID NO: 1, or a fragment thereof having lipase activity."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A method according to any preceding claim wherein the variant is:
a. a polypeptide comprising an amino acid sequence with at least 60% identity with the mature polypeptide of SEQ ID NO: 1;
b. a polypeptide encoded by a polynucleotide that hybridizes under at least low stringency conditions with: (i) the mature polypeptide coding sequence of SEQ ID NO: 1; or (ii) a full-length complementary strand of (i), or
c. a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 60 % identity with the mature polypeptide coding sequence of SEQ ID NO: 1."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A method according to any preceding claim, wherein the substitution in the lipase variant is selected from T37A,D,E,F,G,H,I,L,N,P,Q,R,S,V,W,Y, N39A,C,D,E,F,G,I,K,L,M,P,Q,R,T,V,W,Y, and G91D,H,I,P,Q."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method according to any preceding claim wherein the variant comprises the substitution G91A."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of any preceding claims, wherein the variant further comprises a substitution at one or more positions corresponding to positions D96, T143, A150, E210, G225, T231, N233 and P250 of the mature polypeptide of SEQ ID NO: 1, preferably a substitution selected from D96G, T143A, A150G, E210Q, G225R, T231R, N233R and P250R and mixtures thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of any preceding claim wherein the variant has the following substitutions:
a. G91A +D96G +T231R +N233R;
b. G91Q +T143A +E210Q +T231R +N233R +P250R;
c. G91Q +A150G +E210Q +T231R +N233R +P250R;
d. T37R +N39R +G91A +D96G +T231R +N233R;
e. G91A +D96G +G225R +T231R +N233R;
f. G91Q +E210Q +T231R +N233R +P250R;
g. G91N +E210Q +T231R +N233R +P250R;
h. G91I +E210Q +T231R +N233R +P250R;
i. G91L +E210Q +T231R +N233R; or
j. G91A +D96G +A150G +T231R +N233R."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["A cleaning and/or treatment composition comprising a lipase variant having lipase activity and exhibiting enhanced stability to oxidative degradation, and a detergent adjunct."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A cleaning and/or treatment composition comprising a lipase variant having lipase activity and comprising a substitution at one or more of the positions selected from the group of positions corresponding to T37, N39 and G91 of the mature polypeptide of SEQ ID NO:1, and a detergent adjunct."],"number":15,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}