{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"189-919-390-707-894","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"189-919-390-707-894"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8759,"type":"PATENT","title":"University of Columbia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":13487,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8203,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Total patents: more than 10k
(a) a fragment comprising mature human osteocalcin missing the last 10 amino acids from the C-terminal end;\n
(b) a fragment comprising mature human osteocalcin missing the first 10 amino acids from the N-terminal end;\n
(c) a fragment comprising amino acids 62-90 of SEQ ID NO:2;\n
(d) a fragment comprising amino acids 1-36 of mature human osteocalcin; and\n
(e) variants of the above."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 where the undercarboxylated/uncarboxylated osteocalcin polypeptide comprises an amino acid sequence\n
YLYQWLGAPVPYPDPLX1PRRX2VCX3LNPDCDELADHIGFQEAYRRFYGPV (SEQ ID NO:13)\n
wherein\n
X1, X2 and X3 are each independently selected from an amino acid or amino acid analog, with the proviso that if X1, X2 and X3 are each glutamic acid, then X1 is not carboxylated, or less than 50 percent of X2 is carboxylated, and/or less than 50 percent of X3 is carboxylated,\n
or said osteocalcin polypeptide comprises an amino acid sequence that is different from SEQ. ID. NO:13 at 1 to 7 positions other than X1, X2 and X3; and/or\n
wherein said amino acid sequence of SEQ. ID. NO:13 includes one or more amide backbone substitutions."],"number":10,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}