{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"188-415-298-151-074","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"188-415-298-151-074"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11646,"type":"PATENT","title":"UT M. D. Anderson Cancer Center - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4091,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8312,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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wherein X is O or NH, Y is S or O and R is H, a substituted or unsubstituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, with the provisos that\n\nX is O, then R must be a substituted or unsubstituted C3-C6 cycloalkyl; and\nif X is NH, then R must not be pyrazinyl substituted C1-C6 alkyl,\n
or a stereoisomer, solvate, hydrate, or pharmaceutically acceptable salt thereof."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein Y is S and R is a substituted or unsubstituted C1-C6 alkyl."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein Y is S and R is a substituted or unsubstituted C3-C6 cycloalkyl."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein Y is O and R is a substituted or unsubstituted C3-C6 cycloalkyl."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein Y is O and R is a substituted or unsubstituted C1-C6 alkyl."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R is a substituted or unsubstituted C2-C6 alkenyl."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R is a substituted or unsubstituted C2-C6 alkynyl."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein R is H."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein X is O, Y is O and R is a substituted or unsubstituted cycloalkyl."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein X is O, Y is S and R is a substituted or unsubstituted cycloalkyl."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ia):\n
wherein R1 is substituted or unsubstituted phenyl, unsubstituted pyrrolyl, unsubstituted pyridyl, unsubstituted furanyl, unsubstituted thienyl, unsubstituted benzofuranyl, unsubstituted benzo[b]thiophenyl, or unsubstituted thiazolyl."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ib):\nwherein R1 is substituted or unsubstituted phenyl, unsubstituted pyrrolyl, unsubstituted pyridyl, unsubstituted furanyl, unsubstituted thienyl, unsubstituted benzofuranyl, unsubstituted benzo[b]thiophenyl, or unsubstituted thiazolyl."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ic):\n
wherein R1 is substituted or unsubstituted phenyl, unsubstituted pyrrolyl, unsubstituted pyridyl, unsubstituted furanyl, unsubstituted thienyl, unsubstituted benzofuranyl, unsubstituted benzo[b]thiophenyl, or unsubstituted thiazolyl; and X is S or O."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["A method of inducing neuronal differentiation in a stem cell comprising contacting said stem cell with a compound of formula (II):\nwherein:\n
R1 is substituted or unsubstituted thiophenyl or a substituent of formula (A):\n\n
wherein:\n\nRA, RB and RD are each independently selected from the group consisting of hydrogen, halogen, alkyl (e.g., C1-C6 alkyl, C3-C6 cycloalkyl), aralkyl, aryl, cyano, nitro, and a carbonyl group; and\nG is O, —NH, or S;\n
R2 is hydrogen, hydroxy, halogen, nitro, aryl, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, aralkyl, —CHO, —C(O)R9, —OC(O)R9, —OC(O)OR9, —O(CN)OR9, —C(O)NR9R10, —OC(O)NR9R10, —NR9OR5, or —SO3R9; wherein R9 and R10 are each independently hydrogen, alkyl, aryl, or aralkyl;\n
R3 is —NH—O-alkyl, —NH—OH, —OR11 or —NR11R12, wherein\n\nR11 and R12 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; or\nR11 and R12 together form a cyclic group; or\nR11 and R12 together with the nitrogen to which they are bound form a cyclic group;\n
X is O or —NR13, wherein R13 is hydrogen, alkyl, aryl, or aralkyl;\nor a stereoisomer, solvate, hydrate, or pharmaceutically acceptable salt thereof."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14, wherein any alkyl group comprised in any of R2, R9, R10, R11, R12, or R13 is lower alkyl."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 15, wherein the cyclic group formed by R11 and R12 is cyclopropyl, cyclobutyl, or cyclopentyl."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14, wherein the compound of formula (II) is further defined as a compound of formula (III):\nwherein:\n
R1 and R2 are both hydrogen; or\n
R1 is hydrogen and R2 is selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl and benzyl; or\n
R1 and R2 may be joined together to form a ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl;\n
R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, substituted or unsubstituted aromatic or heteroaromatic ring, cyano, nitro, and a carbonyl group;\n
X is O, NH, or S; and\n
Y is O, NH, or S,\nor a stereoisomer, solvate, hydrate, or pharmaceutically acceptable salt thereof."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is S and R2 is a substituted or unsubstituted C1-C6 alkyl."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is S and R2 is a substituted or unsubstituted C3-C6 cycloalkyl."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is O and R2 is a substituted or unsubstituted C3-C6 cycloalkyl."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is O and R2 is a substituted or unsubstituted C1-C6 alkyl."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is S and R2 is a substituted or unsubstituted C2-C6 alkenyl, C2-C6 alkynyl or benzyl."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein Y is O and R2 is a substituted or unsubstituted C2-C6 alkenyl, C2-C6 alkynyl or benzyl."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein R1 is H."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein said stem cell is located in an animal subject."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 17, wherein said stem cell is contacted ex vivo."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 14, wherein the compound of formula (II) is further defined as a compound of formula (IV):\nwherein:\n
R1 is selected from C1-6alkyl and a 5- or 6-membered ring containing atoms independently selected from the group consisting of C, N, O and S,\n
wherein R1 is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halo, nitro, aryl, heteroaryl, C1-6alkylhalo, OC1-6alkylhalo, OC1-6alkyl, C2-6alkenyl, OC2-6alkenyl, C2-6alkynyl, OC2-6alkynyl, C0-6alkylC3-6cycloalkyl, OC0-6alkylC3-6cycloalkyl, C1-6alkylaryl, OC0-6alkylaryl, CHO, (CO)R4, O(CO)R4, O(CO)OR4, O(CN)OR4, C1-6alkylOR4, OC2-6alkylOR4, C1-6alkyl(CO)R4, OC1-6alkyl(CO)R4, C0-6alkylCO2R4, OC1-6alkylCO2R4, C0-6alkylcyano, OC2-6alkylcyano, C0-6alkylNR4R5, OC2-6alkylNR4R5, C1-6alkyl(CO)NR4R5, OC1-6alkyl(CO)NR4R5, C0-6alkylNR4(CO)R5, OC2-6alkylNR4(CO)R4, C0-6alkylNR4(CO)NR4R5, C0-6alkylSR4, OC2-6alkylSR4, C0-6alkyl(SO)R4, OC2-6alkyl(SO)R4, C0-6alkylSO2R4, OC2-6alkylSO2R4, C0-6alkyl(SO2)NR4R5, OC1-6alkyl(SO2)NR4R5, C0-6alkylNR4(SO2)R5, OC2-6alkylNR4(SO2)R5, C0-6alkylNR4(SO2)NR4R5, OC2-6alkylNR4(SO2)NR4R5, (CO)NR4R5, O(CO)NR4R5, NR4OR5, C0-6alkylNR4(CO)OR5, OC2-6alkylNR4(CO)OR5 and SO3R4;\n
R2 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, aryl, heteroaryl, C1-6alkylhalo, OC1-6alkylhalo, C1-6alkyl, OC1-6alkyl, C2-6alkenyl, OC2-6alkenyl, C2-6alkynyl, OC2-6alkynyl, C0-6alkylC3-6cycloalkyl, OC0-6alkylC3-6cycloalkyl, C1-6alkylaryl, OC0-6alkylaryl, CHO, (CO)R4, O(CO)R4, O(CO)OR4, O(CN)OR4, C1-6alkylOR4, OC2-6alkylOR4, C1-6alkyl(CO)R4, OC1-6alkyl(CO)R4, C0-6alkylCO2R4, OC1-6alkylCO2R4, C0-6alkylcyano, OC2-6alkylcyano, C0-6alkylNR4R1, OC2-6alkylNR4R5, C1-6alkyl(CO)NR4R5, OC1-6alkyl(CO)NR4R5, C0-6alkylNR4(CO)R5, OC2-6alkylNR4(CO)R5, C0-6alkylNR4(CO)NR4R5, C0-6alkylSR4, OC2-6alkylSR4, C0-6alkyl(SO)R4, OC2-6alkyl(SO)R4, C0-6alkylSO2R4, OC2-6alkylSO2R4, C0-6alkyl(SO2)NR4R5, OC2-6alkyl(SO2)NR4R5, C0-6alkylNR4(SO2)R5, OC2-6alkylNR4 (SO2)R5, C0-6alkylNR4(SO2)NR4R5, OC2-6alkylNR4(SO2)NR4R5, (CO)NR4R5, O(CO)NR4R5, NR4OR5, C0-6alkylNR4(CO)OR5, OC2-6alkylNR4(CO)OR5 and SO3R4;\n
R3 is selected from the group consisting of OR4, NR4R5, and NR7R8, wherein R7 and R8, together with the nitrogen atom to which they are bound, combine to form a 5- to 6-member ring optionally containing one or more of S, O, and NH;\n
R4 and R5 are independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkylaryl, C1-6alkylheteroaryl, C3-7cycloalkyl and aryl; and\n
X is O or NR6, wherein R6 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkylaryl, C1-6alkylheteroaryl, C3-7cycloalkyl and aryl;\n
or a stereoisomer, solvate, hydrate, or pharmaceutically acceptable salt thereof."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["A method of inducing neuronal differentiation in a stem cell comprising contacting said stem cell with a compound having formula (V):\nwherein:\n
the ABD ring comprises two non-adjacent double bonds;\n
A, B and D are each independently S, N, O, C, —NR14, —CR15, or —CR15R16, wherein R14 is hydrogen, halogen, alkyl, aryl, or aralkyl; and R15 and R16 are each independently hydrogen, hydroxy, halogen, nitro, aryl, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, aralkyl, —CHO, —C(O)R9, —OC(O)R9, —OC(O)OR9, —O(CN)OR9, —C(O)NR9R10, —OC(O)NR9R10, —NR9OR5, or —SO3R9; wherein R9 and R10 are each independently hydrogen, alkyl, aryl, or aralkyl,\n\nprovided that at least two of A, B and D comprise S, N, or O;\n
R1 is alkyl, —CH═CH-aryl, or aryl; and\n
R3 is alkyl, —C(O)alkyl, aryl, —C(O)aryl, aralkyl, —C(O)aryl, —OR4, —C(O)R4, —NR4R5, or —C(O)NR4R5, wherein:\n\nwith the proviso that compounds of formula (Va) are excluded:\nwherein R18 is cyclopentyl or allyl and G is O or S."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein any alkyl group comprised in R1, R4, R5, R9, R10, R14, R15, and/or R16 is lower alkyl."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein the aryl group of either aryl-containing R1 substituent is substituted or unsubstituted pyranyl, thiophenyl, furanyl, thiazolyl, or pyridinyl."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein R4 and R5 together form a cyclopropyl group."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein R3 is —NR4R5."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein the compound of formula (V) is further defined as a compound of formula (Vb):\nwherein:\nR4 and R5 are each independently hydrogen, alkyl, aryl, or aralkyl;\nR4 and R5 together form a cyclic group; or\nR4 and R5 together with the nitrogen to which they are bound form a cyclic group;\n
R1 and R2 are each independently hydrogen, alkyl, —CH═CH-aryl, aralkyl, or aryl; and\n
R3 is alkyl, aryl, aralkyl, —OR4, or —NR4R5, wherein:\n"],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein the ABD ring is selected from the group consisting of:"],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein the compound of formula (V) is further defined as any one or more of the following compounds:"],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein said stem cell is located in an animal subject."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein said stem cell is contacted ex vivo."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating a brain tumor comprising administrating to a patient a compound of formula (I), (Ia), (Ib), (Ic), (II) or (V)."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein the brain tumor is selected from the group consisting of a glioma, a glioblastoma, an astrocytoma, an oligodendroglioma, an ependymoma, a meningioma, or a medulloblastoma."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein the brain tumor is glioblastoma multiforme, anaplastic astrocytoma, infiltrative astrocytoma, pilocytic astrocytoma, mixed oligoastrocytoma, or mixed glioma."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein the compound of formula (I), (Ia), (Ib), (Ic), (II) or (V) is administered intratumorally."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, further comprising resection of the tumor."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein the compound of formula (I), (Ia), (Ib), (Ic), (II) or (V) is administered to the tumor bed after the tumor has been resected."],"number":44,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}R4 and R5 are each independently hydrogen, alkyl, aryl, or aralkyl; or\nR4 and R5 together form a cyclic group; or\nR4 and R5 together with the nitrogen to which they are bound form a cyclic group.\n