{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"186-101-713-846-988","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"186-101-713-846-988"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search Applicants and Owners separately: \"Vanderbilt University\"; \"Vanderbilt Uni*\"; \"Uni* Vander*\"
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search Applicants and Owners separately: \"Vanderbilt University\"; \"Vanderbilt Uni*\"; \"Uni* Vander*\"
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and stereoisomers and conjugable analogs thereof."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein signaling moiety is chosen from a lanthanide chealate or a dye."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 2, wherein the dye is a NIR dye."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 2, wherein the dye is:\nand stereoisomers thereof."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 2, wherein the lanthanide chelate is\nwherein:\n
M is a chelating ion selected from the group consisting of gallium (Ga), copper (Cu), nickel (Ni), indium (In), technetium (Tc), yttrium (Y) and lanthanide (Ln) series ions;\n
R1 and R3 are, independently,\n\n
R4 is H, CH3, C2H5, C3H7, C4H9, C5H11, C6H13;\nA is a sensitizer; andR5 is the conjugation site of the CB2 receptor ligand of the present invention."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A compound of claim 1, of the following formula:\n\nand stereoisomers and conjugable forms thereof."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 6, wherein halo is chlorine."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, of the following formula:\n\nand stereoisomers and conjugable forms thereof."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein DRUG is etopiside or a conjugable analog thereof."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A compound of claim 1, of the following formula:\nand stereoisomers thereof."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A compound of claim 1, of the following formula:\nand stereoisomers thereof."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A compound of claim 1, of the following formula:\nand stereoisomers thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A conjugate comprising:\n
a compound of the following formula:\n\nwherein X is H or substituted with\nwith at least X being substituted; and halo is fluorine, chlorine, bromine, iodine, and stereoisomers and conjugable analogs thereof; and\n
an imaging agent or therapeutic agent binded thereto."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, of the following formula:\nand stereoisomers thereof."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, of the following formula:\n
wherein M is chelating ion selected from the group consisting of gallium (Ga), copper (Cu), nickel (Ni), indium (In), technetium (Tc), yttrium (Y), lutetium (Lu) and lanthanide (Ln) series ions;\n
and stereoisomers thereof."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, of the following formula:"],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, of the following formula:\nand stereoisomers thereof."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, wherein the imaging agent is an NIR dye, and conjugable analogs thereof."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The conjugate of claim 13, wherein the therapeutic agent is etopiside or a conjugable analog thereof."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A method for delivering an agent to a sample of cells, comprising:\n
(a) forming a conjugate of following formula:\n\nwherein X is H or substituted with\nwith at least one X being substituted; and halo is fluorine, chlorine, bromine, iodine, and stereoisomers and conjugable analogs thereof; and\n
an agent having an affinity for a target binded thereto; and\n
(b) introducing the conjugate to the sample."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein the agent is a signaling moiety."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein the agent is selected from an NIR dye, lanthanide chealate compound, or therapeutic agent."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 20, wherein the sample is chosen from at least one of cells, tissue, cellular tissue, serum, cell extract, bodily fluids."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["A method of imaging a molecular event in a sample, comprising:\n
(a) administering to said sample a probe having an affinity for a target, the probe comprising a compound of the following formula:\n\n
(b) detecting a signal from said probe."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein the sample is chosen from at least one of cells, tissue, cellular tissue, serum, cell extract, bodily fluids."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein DYE is an NIR dye or a conjugable form thereof."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, further comprising the steps of (c) after a period of time from step (b), administering the probe to a second sample, (d) detecting a second signal; and (e) comparing the first signal with the second signal to determine the progress of a disease state."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["A method of delivering a therapeutic agent to a targeted cell, comprising administering to a patient in need thereof a compound of the following formula:\nor a stereoisomer thereof."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein DRUG is a topoisomerase inhibitor or a conjugable form thereof."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 29, wherein the topoisomerase inhibitor is selected from the group consisting of adriamycin, amsacrine, camptothecin, daunorubicin, dactinomycin, doxorubicin, eniposide, epirubicin, etoposide, idarubicin, mitoxantrone, teniposide, and topotecan; and conjugable forms thereof."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein DRUG is etopiside, or conjugable forms thereof."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, and a pharmaceutically acceptable carrier."],"number":32,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}