{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"176-325-205-676-134","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"176-325-205-676-134","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8759,"type":"PATENT","title":"University of Columbia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":13487,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8203,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Total patents: more than 10k
(a) contacting a sample from the subject with a capturing antibody which specifically or preferentially binds to nicked hCG, under conditions permitting formation of a complex between the capturing antibody and the nicked hCG;\n
(b) determining the amount of complexes formed in step (a) thereby determining the amount of nicked hCG in the sample; and\n
(c) comparing the amount of nicked hCG in the sample determined in step (b) with the amount determined for a normal pregnant subject, wherein the elevated level of nicked hCG in the sample as compared to that in the normal pregnant subject is indicative of Down's syndrome in the fetus."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the capturing antibody is B151."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the complex formed in step (a) is detected by a detection antibody."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the detection antibody is B207."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the detection antibody is labeled with a detectable marker."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the sample is a urinary sample or a blood sample."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A method for determining the amount of nicked hCG in a sample comprising:\n
(a) contacting the sample with a capturing antibody which specifically or preferentially binds to nicked hCG under conditions permitting formation of a complex between the capturing antibody and the nicked hCG, wherein the capturing antibody is B151; and\n
(b) determining the amount of complexes formed in step (a) thereby determining the amount of nicked hCG in the sample."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the complex formed in step (a) is detected by a detection antibody."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 8, wherein the detection antibody is B207."],"number":9,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}