{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"171-194-642-332-146","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"171-194-642-332-146","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11813,"type":"PATENT","title":"University of Aberdeen Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":27926,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8443,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* aberdeen. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1658
Search Applicants and Owners separately: univ* aberdeen. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1658
wherein:\n
Ar1 is independently a group of the following formula:\n\n
wherein:\n
q is independently an integer from 0 to 4;\n
r is independently an integer from 0 to 5; and\n
each RP is independently selected from: (1) carboxylic acid; (2) ester; (3) amido; (4) acyl; (5) halo; (6) cyano; (7) nitro; (8) hydroxy; (9) ether; (10) thiol; (11) thioether; (12) acyloxy; (13) amino; (14) acylamino; (15) aminoacylamino; (16) sulfonamino; (17) sulfonyl; (18) sulfonate; (19) sulfonamido; (22) C3-20heterocyclyl; (23) C1-7alkyl; (24) oxo; (25) imino; (26) hydroxyimino; and (27) phosphate;\n
Ralk is independently a C4-8alkylene group, and is unsubstituted, or substituted with one or more substituents selected from: halogen, hydroxy, C1-7alkoxy, amino, and amido;\n
—ORO, if present, is independently —OH or —ORK;\n
—ORK, if present, is independently selected from:\n
—O—RK1;\n
—O—C(═O)RK2;\n
—O—C(═O)ORK3;\n
—O—S(═O)2ORK4;\n
wherein:\n
each of RK1, RK2, RK3, and RK4 is independently C5-20aryl-C1-7alkyl, C5-20aryl, C3-20heterocyclyl, or C1-7alkyl, and is optionally substituted; and\n
each of RK3 and RK4 may additionally be —H;\n
Q is independently —OH or —OROT;\n
wherein:\n
—OROT, if present, is independently: —O—RE1;\n
wherein:\n
RE1 is independently: C5-20aryl-C1-7alkyl, unsubstituted or substituted with one or more groups selected from (1) carboxylic acid; (2) ester; (3) amido; (4) acyl; (5) halo; (6) cyano; (7) nitro; (8) hydroxy; (9) ether; (10) thiol; (11) thioether; (12) acyloxy; (13) amino; (14) acylamino; (15) aminoacylamino; (16) sulfonamino; (17) sulfonyl; (18) sulfonate; (19) sulfonamido; (20) C5-20aryl-C1-7alkyl; (21) C5-20aryl; (22) C3-20heterocyclyl; (23) C1-7alkyl; (24) oxo; (25) imino; (26) hydroxyimino; and (27) phosphate; C5-20aryl, unsubstituted or substituted with one or more groups selected from (1) carboxylic acid; (2) ester; (3) amido; (4) acyl; (5) halo; (6) cyano; (7) nitro; (8) hydroxy; (9) ether; (10) thiol; (11) thioether; (12) acyloxy; (13) amino; (14) acylamino; (15) aminoacylamino; (16) sulfonamino; (17) sulfonyl; (18) sulfonate; (19) sulfonamido; (20) C5-20aryl-C1-7alkyl; (21) C5-20aryl; (22) C3-20heterocyclyl; (23) C1-7alkyl; (24) oxo; (25) imino; (26) hydroxyimino; and (27) phosphate;\n
C3-20heterocyclyl, unsubstituted or substituted with one or more groups selected from (1) carboxylic acid; (2) ester; (3) amido; (4) acyl; (5) halo; (6) cyano; (7) nitro; (8) hydroxy; (9) ether; (10) thiol; (11) thioether; (12) acyloxy; (13) amino; (14) acylamino; (15) aminoacylamino; (16) sulfonamino; (17) sulfonyl; (18) sulfonate; (19) sulfonamido; (20) C5-20aryl-C1-7alkyl; (21) C5-20aryl; (22) C3-20heterocyclyl; (23) C1-7alkyl; (24) oxo; (25) imino; (26) hydroxyimino; and (27) phosphate; or\n
C1-7alkyl, unsubstituted or substituted with one or more groups selected from (1) carboxylic acid; (2) ester; (3) amido; (4) acyl; (5) halo; (6) cyano; (7) nitro; (8) hydroxy; (9) ether; (10) thiol; (11) thioether; (12) acyloxy; (13) amino; (14) acylamino; (15) aminoacylamino; (16) sulfonamino; (17) sulfonyl; (18) sulfonate; (19) sulfonamido; (20) C5-20aryl-C1-7alkyl; (21) C5-20aryl; (22) C3-20heterocyclyl; (24) oxo; (25) imino; (26) hydroxyimino; and (27) phosphate;\n
wherein the group —C(═O)— in formula (1) is optionally replaced with a group selected from the following groups, wherein each R is independently C5-20aryl-C1-7alkyl, C5-20aryl, C3-20heterocyclyl, or C1-7alkyl, and is optionally substituted:\n\n
with the proviso that if —OROT is —O—RE1, then RE1 is not a phenyl group substituted with a sulfonyl group; and\n
with the proviso that —ORO, if present, is other than siloxy."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein the group —C(═O)— in formula (1) is not replaced as described in claim 1."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 2, wherein the compound is selected from compounds of formula (1) and pharmaceutically acceptable salts, amides, esters, and ethers thereof."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 2, wherein the compound is selected from compounds of formula (2) and pharmaceutically acceptable salts, amides, esters, and ethers thereof."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein:\n
each of RK1, RK2, RK3, and RK4, if present, is independently C1-7alkyl, and is optionally substituted; and\n
each of RK3 and RK4, if present, may additionally be —H."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein —ORO, if present, is independently —OH."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 3, wherein Ralk is a fully saturated C4-8alkylene group and is unsubstituted."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein Ralk is a fully saturated C4-8alkylene group and is unsubstituted."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 6, wherein Ralk is a fully saturated C4-8alkylene group and is unsubstituted."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 3, wherein Ralk is —(CH2)n— where n is an integer from 4 to 8."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein Ralk is —(CH2)n— where n is an integer from 4 to 8."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 6, wherein Ralk is —(CH2)n— where n is an integer from 4 to 8."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 3, wherein Ralk is —(CH2)5— or —(CH2)6—."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein Ralk is —(CH2)5— or —(CH2)6—."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 6, wherein Ralk is —(CH2)5— or —(CH2)6—."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 3, wherein Q is independently —OH."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 4, wherein Q is independently —OH."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 6, wherein Q is independently —OH."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 7, wherein Q is independently —OH."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 8, wherein Q is independently —OH."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 9, wherein Q is independently —OH."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 10, wherein Q is independently —OH."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 11, wherein Q is independently —OH."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 12, wherein Q is independently —OH."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 13, wherein Q is independently —OH."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 14, wherein Q is independently —OH."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 15, wherein Q is independently —OH."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 25, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
s is an integer from 0 to 2."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 27, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
s is an integer from 0 to 2."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 25, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
s is an integer from 0 to 2."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 27, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
s is an integer from 0 to 2."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 25, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
t is an integer from 0 to 1."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 27, wherein Ar1 is independently a group of the following formula:\n
wherein:\n
q is an integer from 0 to 2; and\n
t is an integer from 0 to 1."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 25, wherein Ar1 is independently a group of the following formula:"],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 27, wherein Ar1 is independently a group of the following formula:"],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein each RP is independently selected from:\n
(1) —C(═O)OH;\n
(2) —C(═O)OMe, —C(═O)OEt, —C(═O)O(iPr), —C(═O)O(tBu); —C(═O)O(cPr); —C(═O)OCH2CH2OH, —C(═O)OCH2CH2OMe, —C(═O)OCH2CH2OEt; —C(O)OPh, —C(═O)OCH2Ph;\n
(3) —(C═O)NH2, —(C═O)NMe2, —(C═O)NEt2, —(C═O)N(iPr)2, —(C═O)N(CH2CH2OH)2;\n
—(C═O)-morpholino, —(C═O)NHPh, —(C═O)NHCH2Ph;\n
(4) —(C═O)Me, —(C═O)Et, —(C═O)(tBu), —(C═O)-cHex, —(C═O)Ph; —(C═O)CH2Ph;\n
(5) —F, —Cl, —Br, —I;\n
(6) —CN;\n
(7) —NO2;\n
(8) —OH;\n
(9) —OMe, —OEt, —O(iPr), —O(tBu), —OPh, —OCH2Ph;\n
—OCF3, —OCH2CF3;\n
—OCH2CH2OH, —OCH2CH2OMe, —OCH2CH2OEt;\n
—OCH2CH2NH2, —OCH2CH2NMe2, —OCH2CH2N(iPr)2;\n
—OPh—Me, —OPh—OH, —OPh—OMe, —OPh—F, —OPh—Cl, —OPh—Br, —OPh—I;\n
(10) —SH;\n
(11) —SMe, —SEt, —SPh, —SCH2Ph;\n
(12) —OC(═O)Me, —OC(═O)Et, —OC(═O)(iPr), —OC(═O)(tBu); —OC(═O)(cPr); —OC(═O)CH2CH2OH, —OC(═O)CH2CH2OMe, —OC(═O)CH2CH2OEt; —OC(O)Ph, —OC(═O)CH2Ph;\n
(13) —NH2, —NHMe, —NHEt, —NH(iPr), —NMe2, —NEt2, —N(iPr)2, —N(CH2CH20H)2;\n
—NHPh, —NHCH2Ph; piperidino, piperazino, morpholino;\n
(14) —NH(C═O)Me, —NH(C═O)Et, —NH(C═O)Ph, —NHC(═O)CH2Ph;\n
—NMe(C═O)Me, —NMe(C═O)Et, —NMe(C═O)Ph, —NMeC(═O)CH2Ph;\n
(15) —NH(C═O)NH2, —NH(C═O)NHMe, —NH(C═O)NHEt, —NH(C═O)NPh, —NH(C═O)NHCH2Ph; —NH(C═S)NH2, —NH(C═S)NHMe, —NH(C═S)NHEt, —NH(C═S)NPh, —NH(C═S)NHCH2Ph;\n
(16) —NHSO2Me, —NHSO2Et, —NHSO2Ph, —NHSO2PhMe, —NHSO2CH2Ph;\n
—NMeSO2Me, —NMeSO2Et, —NMeSO2Ph, —NMeSO2PhMe, —NMeSO2CH2Ph;\n
(17) —SO2Me, —SO2CF3, —SO2Et, —SO2Ph, —SO2PhMe, —SO2CH2Ph;\n
(18) —OSO2Me, —OSO2CF3, —OSO2Et, —OSO2Ph, —OSO2PhMe, —OSO2CH2Ph;\n
(19) —SO2NH2, —SO2NHMe, —SO2NHEt, —SO2NMe2, —SO2NEt2, —SO2-morpholino, —SO2NHPh, —SO2NHCH2Ph;\n
(20) —CH2Ph, —CH2Ph—Me, —CH2Ph—OH, —CH2Ph—F, —CH2Ph—Cl;\n
(21) —Ph, —Ph—Me, —Ph—OH, —Ph—OMe, —Ph—F, —Ph—Cl, —Ph—Br, —Ph—I;\n
pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl; furanyl, thiophenyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl;\n
(22) pyrrolidinyl, piperidinyl, azepinyl, tetrahydropyranyl, morpholinyl, azetidinyl, piperazinyl, imidazolinyl, piperazinedionyl, and oxazolinonyl;\n
(23) —Me, —Et, -nPr, -iPr, -nBu, -iBu, -sBu, -tBu, -nPe;\n
-cPr, -cHex; —CH═CH2, —CH2—CH═CH2;\n
—CF3, —CHF2, —CH2F, —CCl3, —CBr3, —CH2CH2F, —CH2CHF2, and —CH2CF3;\n
—CH2OH, —CH2OMe, —CH2OEt, —CH2NH2, —CH2NMe2;\n
—CH2CH2OH, —CH2CH2OMe, —CH2CH2OEt, —CH2CH2CH2NH2, —CH2CH2NMe2;\n
(24) ═O;\n
(25) ═NH, ═NMe; ═NEt;\n
(26) ═NOH;\n
(27) —OP(═O)(OH)2, —P(═O)(OH)2, —OP(═O)(OMe)2, —P(═O)(OMe)2."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein each RP is independently selected from:\n
(1) —C(═O)OH;\n
(2) —C(═O)OMe, —C(═O)OEt, —C(═O)O(tBu), —C(═O)OPh;\n
(3) —C(═O)NH2, —C(═O)NHMe, —C(═O)NMe2, —C(═O)NHPh;\n
(4) —C(═O)Me;\n
(5) F, Cl, Br, I;\n
(6) —CN;\n
(7) —NO2;\n
(8) —OH;\n
(9) —OMe, —OEt, —O(iPr), —O(nPr), —O(tBu), —OPh, —OBn;\n
(11) —SMe;\n
(12) —OC(C═O)Me, —OC(C═O)Et, —OC(C═O)(tBu), —OC(C═O)Ph;\n
(13) —NH2, —NHMe, —NMe2, —NHEt, —NEt2;\n
(14) —NHC(═O)Me, —NHC(═O)Et, —NHC(═O)Ph;\n
(17) —S(═O)2Me, —S(═O)2Et, —S(═O)2Ph;\n
(19) —SO2NH2,\n
(21) —Ph;\n
(23) —Me, —Et, -iPr, -nPr, -cPr, -tBu, —CF3;\n
(27) —P(═O)(OMe)2."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 25, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 27, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":39,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 28, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":40,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 29, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":41,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 30, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":42,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 31, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":43,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 32, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":44,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 33, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":45,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 34, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":46,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 35, wherein each RP is independently selected from: —Me, —F, —Cl, —Br, —I, —OH, —OMe, —NH2, —NMe2, —NO2, and —CN."],"number":47,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 34, wherein each RP is independently selected from: —F, —Cl, —Br, and —I."],"number":48,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 35, wherein each RP is independently selected from: —F, —Cl, —Br, and —I."],"number":49,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein said compound is selected from the following compounds, and pharmaceutically acceptable salts, amides, esters, and ethers thereof:"],"number":50,"annotation":false,"claim":true,"title":false},{"lines":["A method according to claim 1, wherein said compound is selected from the following compounds, and pharmaceutically acceptable salts, amides, esters, and ethers thereof:"],"number":51,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}