{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"165-739-590-147-60X","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"165-739-590-147-60X","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8761,"type":"PATENT","title":"University of Chicago","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":5987,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8204,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Chicago Univ \", \"Univ Chicago\", \"\"Chicago University \" NOT \"loyola\"\", \" \"Univ Chic* NOT \"Loyola\" \".
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Total patents: 4656
Searched applicants and Owners= \"Chicago Univ \", \"Univ Chicago\", \"\"Chicago University \" NOT \"loyola\"\", \" \"Univ Chic* NOT \"Loyola\" \".
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Total patents: 4656
(a) administering said small organic compound to a transgenic mouse animal, whose genome comprises:\n\n(i) a stably integrated transgenic nucleotide sequence encoding interferon-gamma (IFN-γ) operably linked to an inducible promoter; and\n(ii) a heterozygous knock-out of the endogenous pancreatic endoplasmic reticulum (ER) kinase gene (PERK), wherein upon expression of said IFN-γ said transgenic mouse exhibits a greater degree of demyelination relative to a transgenic animal-mouse having a stably integrated transgenic nucleotide sequence encoding IFN-γ as in (i), but lacking said heterozygous knock-out of the PERK gene;\n
(b) determining whether said small organic compound effectively modulates neuronal demyelination in the nervous system."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determining in step (b) is by characterizing a loss of oligodendrocytes or Schwann cells in said nervous system."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determining in step (b) characterizing is by a decrease in myelinated axons in said nervous system."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determining in step (b) is by characterizing a reduction in the level of an oligodendrocyte marker or a Schwann cell marker."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein said oligodendrocyte marker is proteolipid protein (PLP)."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determining in step (b) involves an immunoassay."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determining in step (b) involves a hybridization assay."],"number":7,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}