{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"163-160-760-066-074","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"163-160-760-066-074","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8635,"type":"PATENT","title":"MIT Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":30193,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8198,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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a degradable polyelectrolyte layer having a first electrostatic charge;\n
a first polysaccharide layer disposed next to the degradable polyelectrolyte layer, the polysaccharide layer having a second electrostatic charge, the first and second electrostatic charges being opposite;\n
a carrier layer disposed next to the first polysaccharide layer, the carrier layer including at least one growth factor; and\n
a second polysaccharide layer disposed next to the carrier layer."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the at least one growth factor is a vascular endothelial growth factor (VEGF), a bone morphogenic protein 2 (BMP-2), a bone morphogenic protein 4 (BMP-4), or a basic fibroblast growth factor (bFGF)."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte is a hydrolysable polyelectrolyte."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the carrier layer has a third electrostatic charge and the second polysaccharide layer has a fourth electrostatic charge, and wherein the first, the second, the third, and the fourth electrostatic charges are alternating anionic and cationic charges."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the carrier layer consists of a protein."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte layer includes a polyelectrolyte selected from the group consisting of a synthetic polyelectrolyte, a natural polyelectrolyte, and a hybrid of a synthetic and a natural polyelectrolyte."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte layer includes one or more polyelectrolytes selected from the group consisting of a polyester, a polyanhydride, a polyorthoester, a polyphosphazene, and a polyphosphoester."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte layer is a polymer that includes one or more polyesters selected from the group consisting of a poly(β-amino ester), a poly(L-lactide-co-L-lysine), a poly(serine ester), a poly(4-hydroxy-L-proline ester), and a poly[α-(4-aminobutyl)-L-glycolic acid]."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte layer is a poly(β-amino ester) that includes a repeating unit represented by a structural formula selected from the group consisting of\n
wherein:\n
each linker B is independently a carbon chain of 1 to 30 carbon atoms or a heteroatom-containing carbon chain of 1 to 30 atoms, each of which is optionally substituted with at least one group selected from a branched or unbranched alkyl, a branched or unbranched alkenyl, a branched or unbranched alkynyl, an amino, an alkylamino, a dialkylamino, a trialkylamino, an aryl, a ureido, a heterocyclic, an aromatic heterocyclic, a cyclic, an aromatic cyclic, a halogen, hydroxyl, an alkoxy, a cyano, an amide, a carbamoyl, a carboxylic acid, an ester, a carbonyl, a carbonyldioxyl, an alkylthioether, or a thiol group;\n
each R1 is independently hydrogen, a branched and unbranched alkyl, a branched or unbranched alkenyl, a branched or unbranched alkynyl, an aryl, a halogen, a hydroxyl, an alkoxy, a carbamoyl, a carboxyl ester, a carbonyldioxyl, an amide, a thiohydroxyl, an alkylthioether, an amino, an alkylamino, a dialkylamino, a trialkylamino, a cyano, a ureido, a substituted alkanoyl, a cyclic, a cyclic aromatic, a heterocyclic, and an aromatic heterocyclic group, each of which is further optionally substituted with at least one substituent selected from the group consisting of a branched or unbranched alkyl, a branched or unbranched alkenyl, a branched or unbranched alkynyl, an amino, an alkylamino, a dialkylamino, a trialkylamino, an aryl, a ureido, a heterocyclic, an aromatic heterocyclic, a cyclic, an aromatic cyclic, a halogen, a hydroxyl, an alkoxy, a cyano, an amide, a carbamoyl, a carboxylic acid, an ester, a carbonyl, a carbonyldioxyl, an alkylthioether, and a thiol group; and\n
n is an integer greater than or equal to 5."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 9, wherein the repeating unit is represented by the following structural formula"],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 9, wherein the repeating unit is represented by the following structural formula"],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 9, wherein the repeating unit is represented by the following structural formula"],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte layer is a polymer that includes one or more of a poly(styrene sulfonate), a poly(acrylic acid), a linear poly(ethylene imine), a poly(diallyl dimethyl ammonium chloride), and a poly(allylamine hydrochloride)."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte is a hydrolysable polyelectrolyte, a thermal degradable polyelectrolyte, an enzymatically degradable polyelectrolyte, or photolyticaly degradable polyelectrolyte."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the degradable polyelectrolyte includes a biodegradable polymer."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 15, wherein the biodegradable polymer includes one of more polymer selected from a polyhydroxyacid, a polypropylfumerate, a polycaprolactone, a polyamide, a poly(amino acid), a polyacetal, a polyether, a polycyanoacrylate, a polyurethane, and a polysaccharide."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the decomposable thin film is a hollow shell."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A device comprising a substrate and the decomposable thin film of claim 1, wherein the decomposable thin film is disposed on the substrate."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The device of claim 18, wherein the substrate is non-planar."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The device of claim 18, wherein the substrate is a particle, a tube, a sphere, a strand, a coiled strand, or a capillary network."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The device of claim 18, wherein the substrate is hydrolytically degradable."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The device of claim 18, wherein the substrate includes a bioactive agent."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The device of claim 18, wherein the substrate includes at least one material selected from a metal, a metal oxide, a plastic, a ceramic, a silicon, a glass, a mica, a graphite, a hydrogel."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the first polysaccharide layer includes a first polysaccharide, the second polysaccharide layer includes a second polysaccharide, and wherein the first and the second polysaccharides are the same."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the first polysaccharide layer and the second polysaccharide layer each includes a polysaccharide independently selected from the group consisting of heparin sulfate, chondroitin sulfate, hyaluronic acid, and dextran sulfate."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 1, wherein the decomposable thin film comprises at least 10 tetralayer units."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The decomposable thin film of claim 26, wherein the decomposable thin film comprises at least N tetralayer units, wherein N is an integer selected from 20, 30, 40, 50, 60 70, and 80."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["A method of releasing a protein, comprising the steps of:\n
providing a decomposable thin film of claim 1; and\n
placing the decomposable thin film in a medium, thereby causing the release of the at least one growth factor."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 28, wherein the release of the at least one growth factor exhibits linear kinetics over a period of at least M days, wherein M is an integer selected from 5, 10, and 14."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 28, wherein the release of the at least one growth factor continues over a period of at least K days, wherein K is an integer selected from 5, 10, 15, 20, 25, 30, and 34."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 28, wherein the at least one growth factor retains at least P % activity after the release, wherein P is an integer selected from 50, 60, 70, 80, and 90."],"number":31,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}