{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"161-167-116-176-888","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"161-167-116-176-888","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11844,"type":"PATENT","title":"University of Kansas Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8584,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8456,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* AND Kansas. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1781
Search Applicants and Owners separately: univ* AND Kansas. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1781
wherein:\n
each R1 is independently selected from selected from the group consisting of:\n\n
each R2 is independently selected from an electron-withdrawing group;\n
each X is independently halo;\n
each R4 is independently selected from the group consisting of —H and —COO(alkyl), and\n
each R5 is independently selected from optionally substituted alkyl;\n
wherein if the compound of formula (III) bears a positive charge, it further comprises at least one counterion Z⊖."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R1 is —CH2X."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein each X is chloro."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R1 is —CH(X)—R4."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4, wherein X is chloro."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4 wherein R4 is —C(O)OC(CH3)3."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R1 is —CH2—N(Ra)3⊕."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7, wherein each Ra is methyl."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R2 is independently selected from the group consisting of nitro, cyano and carboxy."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein each R2 is nitro."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is selected from the group consisting of:"],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating cancer in a subject in need of treatment, comprising administering the subject a therapeutically effective amount of a compound of claim 1, wherein the cancer is selected from the group consisting of leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein the subject is a human."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising administering an additional chemotherapeutic agent."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, further comprising administering radiation."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A method of reducing the proliferation of a cancer cell, comprising contacting the cancer cell with an effective amount of a compound of claim 1, wherein the cancer cell is selected from the group consisting of leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer."],"number":16,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}