{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"160-824-751-430-460","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"160-824-751-430-460"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8902,"type":"PATENT","title":"University of Tokyo Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":20983,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8217,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners = \"Univ Tokyo\", \"Univ Tokyo NOT metropolitan\", \"Tokyo Univ\",\"University of Tokyo NOT metropolitan\", \"Tokyo Univ\".
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Total patent: 13934
Search applicants and owners = \"Univ Tokyo\", \"Univ Tokyo NOT metropolitan\", \"Tokyo Univ\",\"University of Tokyo NOT metropolitan\", \"Tokyo Univ\".
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Total patent: 13934
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R3 and R4 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R9 and R10 are, each independently, a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R9 or R10 optionally forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds, and optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl, or C6-10 alkyl-substituted alkenyl group;\n
Y is selected from\n
(1) NR11R12\n
(2) OR13 or\n
(3) —N═N—R14\n
where:\n
R11 is a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R12 is a hydrogen atom, C1-6 alkyl group, or acyl group;\n
R11 and R12 optionally form a 5-7-member heterocyclyl containing a nitrogen atom to which R11 and R12 bind, and optionally contain 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl optionally being substituted by a C1-6 alkyl group;\n
R13 is a hydrogen atom or monovalent substituent cleaved by contact with a measured substance; and\n
R14 is an aryl group; and\n
X is a silicon, germanium, or tin atom;\n
when Y is —NR11R12, (i) R9 and R10 are not monovalent substituents cleaved by contact with a measured substance, and (ii) at least one of R9 and R10 differs from at least one of R11 and R12; provided that a compound wherein R9 and R10 are hydrogen, R12 is a hydrogen, and R11 is a monovalent substituent cleaved by contact with a measured substance, is excluded;\n
when Y is —OR13 and R13 is a hydrogen atom, R9 or R10 is optionally a monovalent substituent cleaved by contact with a measured substance; and\n
when Y is —N═N—R14, R9 and R10 are not a monovalent substituent cleaved by contact with a measured substance."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 1 having the structure of formula (Ia) below, Y being —NR11R12\n
where:\n
R1 to R12 and X are as defined in formula (I), but (i) R9 and R10 are not monovalent substituents cleaved by contact with a measured substance, and (ii) when R11 and R12 are hydrogen atoms, R9 and R10 are not both hydrogen atoms."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 2, wherein R9 or R10 forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds; wherein the heterocyclyl or heteroaryl optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl group, or C6-10 alkyl-substituted alkenyl group."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 3, wherein R9 forms, together with R3, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 binds."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 4, having the structure of formula (Ia-1) below\n
where R1-R2, R4-R8, R10-R12, and X are as defined in formula (Ia)."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 2, wherein R11 and R12 form a 5-7-member heterocyclyl containing a nitrogen atom to which R11 and R12 bind; wherein the heterocyclyl optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl optionally being substituted by a C1-6 alkyl group."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ia) below or a salt thereof\n
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R3 and R4 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R9 and R10 are, each independently, a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R9 or R10 optionally forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds, and optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl, or C6-10 alkyl-substituted alkenyl group;\n
X is a silicon, germanium, or tin atom;\n
R9 and R10 are not monovalent substituents cleaved by contact with a measured substance; and\n
R11 and R12 form a piperazine ring together with a nitrogen atom to which R11 and R12 bind."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 7, having the structure of formula (Ia-2) below\n
where R1-R10 and X are as defined in formula (Ia), and R15 is a C1-6 alkyl group."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (I) below or a salt thereof\n
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R3 and R4 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R9 and R10 are, each independently, a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R9 or R10 optionally forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds, and optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl, or C6-10 alkyl-substituted alkenyl group;\n
Y is —NR11R12\n
where:\n
R11 is a monovalent substituent cleaved by contact with an enzyme selected from the group consisting of peptidase, protease, lactamase, glycohydrolase, transferase, and oxidoreductase;\n
R12 is a hydrogen atom, C1-6 alkyl group, or acyl group;\n
X is a silicon, germanium, or tin atom; and\n
R9 and R10 are not monovalent substituents cleaved by contact with a measured substance."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 9, wherein R11 is a monovalent substituent cleaved by contact with an enzyme selected from the group consisting of peptidase, protease, and lactamase."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 9, wherein the peptidase or protease is an enzyme selected from the group consisting of caspase, prostate-specific antigen, leucine aminopeptidase, and γ-glutamyl transpeptidase."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 2, wherein R11 is an aromatic ring and R3 and R9 together form a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 binds; and R12 is a C1-6 alkyl group."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ia-3) below or a salt thereof\n
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R4 is a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R10 is a hydrogen atom or C1-6 alkyl group;\n
R12 is a hydrogen atom, C1-6 alkyl group, or acyl group; and\n
X is a silicon, germanium, or tin atom."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 13, having the structure of formula (1) below"],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ib) below or a salt thereof\n
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R3 and R4 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R9 and R10 are, each independently, a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R9 or R10 optionally forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds, and optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl, or C6-10 alkyl-substituted alkenyl group;\n
R13 is a hydrogen atom or monovalent substituent cleaved by contact with a measured substance; and\n
X is a silicon, germanium, or tin atom; and\n
when R13 is a hydrogen atom, R9 or R10 are optionally a monovalent substituent cleaved by contact with a measured substance."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 15, wherein R13, R9, or R10 is a monovalent substituent cleaved by contact with an enzyme selected from the group consisting of peptidase, protease, lactamase, glycohydrolase, transferase, and oxidoreductase."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 16, wherein R13, R9, or R10 is a monovalent substituent cleaved by contact with an enzyme selected from the group consisting of peptidase, protease, and lactamase."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 17, wherein the monovalent substituent is cleaved by a peptidase or protease selected from the group consisting of caspase, prostate-specific antigen, leucine aminopeptidase, and γ-glutamyl transpeptidase."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A compound of formula (Ic) below or a salt thereof\n
where:\n
R1 is a hydrogen atom or 1-4 of the same or different monovalent substituents present on a benzene ring;\n
R2 is a monovalent substituent;\n
R3 and R4 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R5 and R6 are, each independently, a C1-6 alkyl group or aryl group;\n
R7 and R8 are, each independently, a hydrogen atom, C1-6 alkyl group, or halogen atom;\n
R9 and R10 are, each independently, a hydrogen atom, C1-6 alkyl group, or monovalent substituent cleaved by contact with a measured substance;\n
R9 or R10 optionally forms, together with R3 or R7, a 5-7-member heterocyclyl or heteroaryl containing a nitrogen atom to which R9 or R10 binds, and optionally contains 1-3 additional heteroatoms selected from the group consisting of oxygen atoms, nitrogen atoms, and sulfur atoms as ring-constituting members; the heterocyclyl or heteroaryl optionally being substituted by a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aralkyl, or C6-10 alkyl-substituted alkenyl group;\n
R14 is an aryl group;\n
X is a silicon, germanium, or tin atom; and\n
R9 and R10 are not a monovalent substituent cleaved by contact with a measured substance."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The compound or salt thereof according to claim 19, wherein the aryl group of R14 is a monocyclic aromatic group or a condensed aromatic group, and the aryl group has a substituent selected from an amino group and a dimethyl amino group."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A fluorescent probe containing the compound defined in claim 1."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["An active-oxygen-detecting fluorescent probe containing the compound of claim 12."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["A low-oxygen-environment-detecting fluorescent probe containing the compound of claim 19."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["A method for manufacturing the compound of formula (Ia) of claim 2 wherein R1-R12 and X are as defined above, or salt thereof, wherein the method comprises:\n
(a) reacting a 3-halo-N,N-diallyl aniline of formula (II), where R16 represents a halogen atom, manufactured from a 3-halogenated aniline and an allyl halide, and a 3-halobenzene amine compound of formula (III), in the presence of formamide, to produce a compound of formula (IV) below;\n\n
(b) reacting the compound of formula (IV) and X(Halo)2(R5)(R6), where Halo is a chlorine atom or a bromine atom; and X, R5, R6 are as defined above, and subsequently producing a compound of formula (V) below by oxidation;\n\n
(c) manufacturing a compound of formula (VI) below from a halobenzene derivative and the compound of formula (V); and\n\n
(d) de-allylating the compound of formula (VI), and manufacturing a compound in which R11 and R12 in formula (Ia) are hydrogen atoms, wherein when a protecting group is introduced into R1 and R2 to manufacture the compound of formula (VI), the protecting group may be deprotected before, after, or simultaneously with step (d)."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 24, further comprising introducing, as R11, a monovalent substituent cleaved by contact with a measured substance."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["A method for manufacturing the compound of formula (Ia) of claim 2, wherein R1-R12 and X are as defined above, or salt thereof, wherein the method comprises:\n
(1) reacting a 3-halo-N,N-diallyl aniline of formula (VII), where R16 represents a halogen atom, manufactured from a 3-haloaniline and an allyl halide in the presence of phosphorus oxychloride under basic conditions to manufacture a 3-halo-N,N-diallyl-4-hydroxymethylaniline of formula (VIII);\n\n
(2) reacting the 3-halo-N,N-diallyl-4-hydroxymethyl aniline and a 3-halobenzene amine compound of formula (IX) to manufacture a compound of formula (X);\n\n
(3) reacting the compound of formula (X) and X(Halo)2(R5)(R6), wherein Halo is a chlorine atom or a bromine atom; and X, R5, and R6 are as defined above, and subsequently manufacturing, by oxidation, N,N-diallylamino-N′,N′-dialkylamino-X-xanthone of formula (V) below;\n\n
(4) manufacturing a compound of formula (VI) below from the N,N-diallylamino-N′,N′-dialkylamino-X-xanthone and a halobenzene derivative; and\n\n
(5) de-allylating the compound of formula (VI), and manufacturing a compound in which R11 and R12 in formula (Ia) are hydrogen atoms, wherein when a protecting group is introduced into R1 and R2 to manufacture the compound of formula (VI), the protecting group may be deprotected before, after, or simultaneously with step (4)."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 26, further comprising introducing, as R11, a monovalent substituent cleaved by contact with a measured substance."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["A method for manufacturing the compound or salt thereof of formula (Ib) of claim 15, wherein the method comprises:\n
(1) reacting a compound of formula (XI) below, under basic conditions, with trifluoromethanesulfonic anhydride (Tf2O) to manufacture a compound of general formula (XII) below;\n\n
(2) reacting the compound of formula (XII) with an imine compound, and thereby manufacturing a compound of formula (XIII); and\n\n
(3) optionally reacting the compound of formula (XIII) with an alkyl halide."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["A method for manufacturing the compound or salt thereof of formula (Ia-3) of claim 13, wherein the method comprises:\n
(1) reacting a compound of formula (XIV) with potassium iodide, and thereby manufacturing a compound of formula (XV);\n\n
(2) reacting the compound of formula (XV) with N-alkyl-p-anisidine, in which the alkyl group has 1-6 carbons, and thereby manufacturing a compound of formula (XVI);\n\n
(3) reacting the compound of (XVI) with o-tolylmagnesium bromide, and subsequently adding an acid to manufacture a compound of formula (XVII); and\n\n
(4) reacting the compound of formula (XVII) with boron tribromide, and thereby manufacturing a compound of formula (Ia-3)."],"number":29,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}