{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"159-398-314-521-52X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"159-398-314-521-52X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8901,"type":"PATENT","title":"University of Michigan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8216,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
(a) a nucleotide sequence encoding the BAIT (Brain-Associated Inhibitor of Tissue-Type Plasminogen Activator) polypeptide having the complete amino acid sequence in FIGS. 1A-1B (SEQ ID NO:2);\n
(b) a nucleotide sequence encoding the mature BAIT polypeptide having the amino acid sequence at positions 19 to 410 in FIGS. 1A-1B (SEQ ID NO:2);\n
(c) a nucleotide sequence encoding a polypeptide having the amino acid sequence consisting of residues n-410 of SEQ ID NO:2, where n is an integer in the range of 2-49;\n
(d) a nucleotide sequence encoding a polypeptide having the amino acid sequence consisting of residues 1-m of SEQ ID NO:2, where m is an integer in the range of 381-409;\n
(e) a nucleotide sequence encoding a polypeptide having the amino acid sequence consisting of residues n-m of SEQ ID NO:2, where n is an integer in the range of 2-49 and m is an integer in the range of 381-409;\n
(f) a nucleotide sequence encoding a polypeptide consisting of a portion of the complete BAIT amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit 97722 wherein said portion excludes up to 48 amino acids from the amino terminus and up to 30 amino acids from the C-terminus of said complete amino acid sequence;\n
(g) a complete nucleotide sequence as shown in FIGS. 1A-1B (SEQ ID NO:1);\n
(h) a complete nucleotide sequence as shown in FIGS. 1A-1B (SEQ ID NO:1) wherein said nucleotide sequence encodes the BAIT polypeptide having the complete amino acid sequence in FIGS. 1A-1B (SEQ ID NO:2);\n
(i) a nucleotide sequence as shown in FIGS. 1A-1B (SEQ ID NO:1) wherein said nucleotide sequence encodes the mature BAIT polypeptide having the amino acid sequence in FIGS. 1A-1B (SEQ ID NO:2);\n
(j) a nucleotide sequence of the cDNA clone contained in ATCC® Deposit No. 97722;\n
(k) a nucleotide sequence encoding the BAIT polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit No. 97722;\n
(l) a nucleotide sequence encoding the mature BAIT polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit No. 97722;\n
(m) a nucleotide sequence comprising a polynucleotide which encodes the amino acid sequence of an epitope-bearing portion of a BAIT polypeptide having an amino acid sequence in (a), (b), (c), (d), (f), (g), (i), or (j); and,\n
(n) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (h), (i), (k), (l), or (m)."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["A method for making a recombinant vector comprising inserting the isolated nucleic acid molecule of claim 1 into a vector."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant vector produced by the method of claim 2."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A method of making a recombinant host cell comprising introducing the recombinant vector of claim 3 into a host cell."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant host cell produced by the method of claim 4."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant method for producing a BAIT polypeptide comprising: \n
(a) culturing the recombinant host cell of claim 5 under conditions such that said polypeptide is expressed; and,\n
(b) recovering said polypeptide."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["An isolated BAIT polypeptide having an amino acid sequence at least 97% identical to a sequence selected from the group consisting of: \n
(a) the amino acid sequence of the BAIT polypeptide having the complete amino acid sequence in SEQ ID NO:2;\n
(b) the amino acid sequence of the mature BAIT polypeptide having the amino acid sequence at positions 19 to 410 in SEQ ID NO:2;\n
(c) amino acid residues n to 410 of SEQ ID NO:2, where n is an integer in the range of 2 to 49;\n
(d) amino acid residues 1 to m of SEQ ID NO:2, where m is an integer in the range of 381 to 410;\n
(e) amino acid residues n to m of SEQ ID NO:2, where n is an integer in the range of 2 to 49 and m is an integer in the range of 381 to 410;\n
(f) a polypeptide comprising amino acids 342-378 of SEQ ID NO:2;\n
(g) the amino acid sequence of the BAIT polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit No. 97722;\n
(h) the amino acid sequence of the complete polypeptide, excluding the N-terminal methionine residue, which amino acid sequence is encoded by the cDNA clone contained in ATCC® Deposit No. 97722;\n
(i) the amino acid sequence of the mature BAIT polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit No. 97722;\n
(j) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit 97722 wherein said portion excludes up to 48 amino acid residues from the amino terminus of said complete amino acid sequence;\n
(k) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit 97722 wherein said portion excludes up to 30 amino acid residues from the C-terminus of said complete amino acid sequence;\n
(l) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC® Deposit 97722 wherein said portion excludes up to 48 amino acid residues from the amino terminus and up to 30 amino acids from the C-terminus of said complete amino acid sequence; and,\n
(m) the amino acid sequence of an epitope-bearing portion of any one of the polypeptides of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l)."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The isolated polypeptide of claim 7, wherein the polypeptide further comprises a heterologous polypeptide."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A composition comprising the isolated polypeptide of claim 7."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["An isolated polypeptide comprising an epitope-bearing portion of the BAIT protein, wherein said portion is selected from the group consisting of: a polypeptide comprising amino acid residues from about Val 155 to about Ala 175 (SEQ ID NO:2); a polypeptide comprising amino acid residues from about Phe 186 to about Pro 215 (SEQ ID NO:2); a polypeptide comprising amino acid residues from about Tyr 225 to about Ile 238 (SEQ ID NO:2); a polypeptide comprising amino acid residues from about Leu 242 to about Leu 255 (SEQ ID NO:2); a polypeptide comprising amino acid residues from about Arg 381 to about Gly 386 (SEQ ID NO:2); and a polypeptide comprising amino acid residues from about Met 395 to about Leu 410 (SEQ ID NO:2)."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antibody or fragment thereof that specifically binds to a BAIT polypeptide of claim 7."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The antibody or fragment thereof of claim 11 which is a human antibody."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The antibody or fragment thereof of claim 11 which is a polyclonal antibody."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The antibody or fragment thereof of claim 11 which is a monoclonal antibody."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["An isolated cell that produces the antibody or fragment thereof of claim 11."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A method of detecting BAIT protein in a biological sample comprising: \n
(a) contacting the biological sample with the antibody or fragment thereof of claim 11; and,\n
(b) detecting the BAIT protein in the biological sample."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antibody or fragment thereof obtained from an animal that has been immunized with the polypeptide of claim 7."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method for treating a nervous system disorder or neuronal injury comprising administering to a patient in need thereof an effective amount of the polypeptide of claim 7."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the nervous system disorder or neuronal injury is selected from the group consisting of: \n
(a) amyotrophic lateral sclerosis;\n
(b) multiple sclerosis;\n
(c) spinal cord injury;\n
(d) Alzheimer's disease;\n
(e) stroke;\n
(f) seizure;\n
(g) epilepsy; and,\n
(f) neural tissue tumor."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 18, wherein the method further comprises coadministration of acetylsalicylic acid."],"number":20,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}