{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"155-084-036-895-945","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"155-084-036-895-945","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10776,"type":"PATENT","title":"University of Zurich - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3600,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8246,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Uni* Zurich\"; \"Univ* Zuerich\"; \"Univ* Zuer*\"; \"Zuer* Uni*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2413
Search Applicants and Owners separately: \"Uni* Zurich\"; \"Univ* Zuerich\"; \"Univ* Zuer*\"; \"Zuer* Uni*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2413
(i) to consensus amino acid residues deduced from the amino acid residues found at the corresponding positions of at least two naturally occurring repeat units; or
(ii) to the amino acid residues found at the corresponding positions in a naturally occurring repeat unit."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of claim 1 or 2, wherein said repeat domain further comprises an N- and/or a C-terminal capping module having an amino acid sequence different from any one of said repeat modules."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of any one of claims 1 to 3, wherein said repeat units are ankyrin repeats."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of claim 4, wherein each of said repeat modules comprises the ankyrin repeat sequence motif DxxGxTPLHLAaxx ± ± ± ± ± ± ± ± ± ± GpxpaVpxLLpxGA ± ± ± ± ± DVNAx , wherein \"x\" denotes any amino acid, \"±\" denotes any amino acid or a deletion, \"a\" denotes an amino acid with an apolar side chain, and \"p\" denotes a residue with a polar sidechain."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of any one of claims 1 to 3, wherein said repeat units are leucine-rich repeats (LRR)."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of claim 6, wherein each of said modules comprises the LRR sequence motif xLxxLxLxxN ± xaxx ± a ± ± ± ± a ± ± a ± ± x ± ± , wherein \"x\" denotes any amino acid, \"a\" denotes an aliphatic amino acid, and \"±\" denotes any amino acid or a deletion."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The repeat protein of any one of claims 5 or 7, wherein one or more of the amino acid residues in said consensus sequences are exchanged by an amino acid residue found at the corresponding position in a corresponding naturally occurring repeat unit."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A collection of nucleic acid molecules encoding a collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein said repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of said repeat modules is derived from one or more repeat units of one family of naturally occurring repeat proteins, wherein said repeat units comprise framework residues and target interaction residues, and wherein said repeat proteins differ in at least one position."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A collection of repeat proteins encoded by a collection of nucleic acid molecules according to claim 9."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method for the construction of a collection of nucleic acid molecules according to claim 9, comprising the steps of
(a) identifying a repeat unit from a repeat protein family;
(b) identifying framework residues and target interaction residues in said repeat unit;
(c) deducing at least one type of repeat module comprising framework residues and randomised target interaction residues from at least one member of said repeat protein family; and
(d) constructing nucleic acid molecules each encoding a repeat protein comprising two or more copies of said at least one type of repeat module deduced in step (c)."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A method for obtaining a repeat protein having a predetermined property, comprising the steps of
(a) providing a collection of repeat proteins according to claim 10; and
(b) screening said collection and/or selecting from said collection to obtain at least one repeat protein having said predetermined property."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A repeat protein from a collection according to claim 10, wherein said repeat protein has a predetermined property."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A nucleic acid molecule encoding the repeat protein of claims 1 to 9 or 13."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising the repeat protein of claims 1 to 9 or 13 or the nucleic acid molecule of claim 14, and optionally a pharmaceutically acceptable carrier and/or diluent."],"number":15,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}