{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"154-386-533-512-99X","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"154-386-533-512-99X","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8759,"type":"PATENT","title":"University of Columbia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":13487,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8203,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
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wherein said enzyme is selected from the group consisting of histone deacetylase-like protein (HDLP) and histone deacetylase 1 (HDAC 1);\n
wherein said crystal effectively diffracts X-rays for the determination of the atomic coordinates of said enzyme to a resolution of greater than 4 Å and wherein the structure of said enzyme comprises a conserved core α/β structure characteristic fold wherein said conserved α/β fold comprises an eight-stranded parallel β sheet and eight α helices and wherein four of the helices pack on either face of said parallel β sheet and wherein said structure of said enzyme comprises a root mean square deviation of less than or equal to 1.5 Å in the positions of Cα. atoms for at least ⅔ or more of the amino acids of histone deacetylase-like protein (HDLP) as defined by the atomic coordinates of HDLP according to FIG. 16; and\n
wherein said method comprises: a) selecting a potential ligand by performing rational drug design with the three-dimensional structure determined for the crystal; b) in an assay, contacting the potential ligand with the ligand binding domain of the enzyme; and c) detecting the binding potential of the potential ligand for the ligand binding domain, wherein the potential ligand is selected as a novel drug based on the potential ligand having a greater affinity for the ligand binding domain than that of a known drug."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the enzyme is histone deacetylase-like protein (HDLP)."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the enzyme is histone deacetylase 1 (HDAC1)."],"number":9,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}