{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"153-658-440-617-944","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"153-658-440-617-944"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10731,"type":"PATENT","title":"The University of North Carolina at Chapel Hill - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8887,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8232,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
i. a silane, and\n
ii. a functionalized mono, di or trialkoxysilane,\n
wherein said functionalized mono, di or trialkoxysilane comprises a NO-donor molecule;\n
wherein said nanorod has an aspect ratio of at least 1 and a [NO]max in a range of about 10 ppb/mg to about 16,000 ppb/mg."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said nanorod is mesoporous."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 2, wherein said mesoporous nanorod comprises pores having sizes from about 2 nm to about 50 nm in diameter."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said silane has the formula Si(OR)4, wherein R is a C1-5 alkyl."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 4, wherein said silane is TEOS or TMOS."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said silane is selected from the group consisting of methyltrimethoxysilane (MTMOS), ethyltrimethoxysilane (ETMOS), butyltrimethoxysilane (BTMOS), propyltrimethoxysilane (PTMOS), butyltriethoxysilane (BTEOS), and octadecyltrimethoxysilane (ODTMOS)."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 4, wherein said functionalized mono, di or trialkoxysilane is a nitric oxide functionalized N-(2-aminoethyl)-3-amino-isobutyl-dimethylmethoxysilane (AEAI); aminopropyldimethylethoxysilane (APDE); N-(6-aminohexyl)aminopropyltrimethoxysilane (AHAP3); N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAP3); (3-trimethoxysilylpropyl)di-ethylenetriamine (DET3); (aminoethylaminomethyl)phenethyltrimethoxysilane (AEMP3); [3-(methylamino)propyl]trimethoxysilane (MAP3); N-butylamino-propyltrimethoxysilane(n-BAP3); t-butylamino-propyltrimethoxysilane(t-BAP3); N-ethylaminoisobutyltrimethoxysilane(EAiB3); N-phenylamino-propyltrimethoxysilane (PAP3); and N-cyclohexylaminopropyltrimethoxysilane (cHAP3)."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said aspect ratio is from about 4 to about 12."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said aspect ratio is about 8."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said nanorod has a [NO]max of from about 10 ppb/mg to about 14,000 ppb/mg."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said nanorod has a [NO]max of from about 3,000 ppb/mg to about 7,000 ppb/mg."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said nanorod has a length of less than about 1,700 nm."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said nanorod has a length of from 100 nm to about 1,300 nm."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, further comprising —(CH2CH2O)x— that is covalently bound to said functionalized mono, di, or trialkoxysilane, wherein x is an integer from one to 10,000."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 14, wherein x is an integer from one to 50."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 1, wherein said NO donor is selected from the group consisting of a diazeniumdiolate, nitrosothiol, a nitrosamine, a hydroxyl nitrosamine, a hydroxyl amine, a hydroxyurea, and combination thereof."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The nanorod of claim 16, wherein said NO donor is selected from the group consisting of a diazeniumdiolate."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["A method of preparing the nitric oxide-releasing nanorod of claim 1, comprising:\n
a. contacting a silane with ammonia, sodium acetate, potassium acetate, sodium hydroxide or potassium hydroxide and mixtures thereof in the presence of a surfactant at a temperature T1; to form a first composition;\n
b. allowing said first composition to age for a period of time, P, at a temperature T2 to form a nanorod;\n
c. harvesting said nanorod;\n
d. contacting said harvested nanorod with a mono, di or trialkoxylsilane at a temperature, T3, to form an amine-functionalized nanorod;\n
e. harvesting said amine-functionalized nanorod;\n
f. contacting said harvested amine-functionalized nanorod with NO gas to form a nitric-oxide releasing nanorod; and\n
g. harvesting said nitric-oxide releasing nanorod."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["A method of delivering nitric oxide to a subject, comprising:\n
administering an effective amount of said nitric oxide-releasing nanorod of claim 1 to said subject."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating a bacterial infection in a subject, comprising:\n
administering an effective amount of said nitric oxide-releasing nanorod of claim 1 to a subject in need thereof."],"number":20,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}