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Search Applicants and Owners separately:univ* AND Stuttgart. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1451
Search Applicants and Owners separately:univ* AND Stuttgart. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1451
a) providing a proteinaceous construct comprising a humanized antibody or at least one fragment thereof having\n
i) one or more amino acid sequences of human origin capable of reducing the immunogenic response of said huTNFR1-antagonist in humans, and\n
ii) one or more amino acid sequences of non-human origin capable of selectively binding to huTNFR1 thereby completely blocking the TNFR1 activity,\nwherein the proteinaceous construct comprises the amino acid sequence according to SEQ NO.: 7 as variable domain of the heavy chain (VH) and the amino acid sequence according to SEQ NO.: 8 as variable domain of the light chain (VL), or a fragment of a humanized antibody, wherein the fragment is a scFv comprising the amino acid sequence according to SEQ ID NO.: 9;\n
b) identifying one or more amino acid sequences capable of binding selectively to huTNFR1 by guided selection using one or more of the amino acid sequences of the proteinaceous construct, and\n
c) constructing the antagonist comprising at least one or more of the amino acid sequences identified under step (b)."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The process according to claim 1, wherein the huTNFR1-antagonist reaches complete block of the TNFR1 activity in a Kym-1 human rhabdomyosarcoma cell line model."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The process according to claim 1, wherein a functionally equivalent huTNFR1 specific antibody is obtained capable of selectively binding to huTNFR1."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The process according to claim 3, wherein the huTNFR1 specific antibody is isolated from human gene libraries."],"number":4,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}