{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"144-169-326-743-476","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"144-169-326-743-476"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8819,"type":"PATENT","title":"Yale University","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8278,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8206,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners = \"Yale univ\", \"Univ Yale\", \"Yale University\", \"University Yale\", \"Univ Yal*\", \"Yal* Univ*\", \"Yale Entrepreneurial Institute\".
Select more for logical variants
Add to collection
Select all the results in the collection and expand by simple family
Add to collection
Total patents: 7360
Search applicants and owners = \"Yale univ\", \"Univ Yale\", \"Yale University\", \"University Yale\", \"Univ Yal*\", \"Yal* Univ*\", \"Yale Entrepreneurial Institute\".
Select more for logical variants
Add to collection
Select all the results in the collection and expand by simple family
Add to collection
Total patents: 7360
generating a cardiovascular waveform representing physiological characteristics of a subject;\n
detecting changes in blood volume of the subject by analyzing the cardiovascular waveform using a processor, wherein the analyzing of the cardiovascular waveform includes:\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the cardiovascular waveform is a photoplethysmograph waveform."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the harmonic analysis includes Fourier analysis."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the harmonic analysis includes joint time-frequency analysis."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the harmonic analysis includes a short-time Fourier transformation."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the extraction of the signal is achieved using a peak detection algorithm."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 6, wherein the peak detection algorithm is applied in the frequency range of ventilation."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the cardiovascular waveform is generated using a photoplethysmographic device."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein one or more oscillations of the cardiovascular waveform are representative of ventilatory related fluctuation."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the determining the changes in blood volume includes monitoring a signal in a respiratory frequency range to ascertain changes in a venous component of blood volume."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the determining the changes in blood volume includes monitoring side bands surrounding a signal in a cardiac frequency range to ascertain changes in the arterial component of the blood volume."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein ventilation of the subject is synchronized with a metronome."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A method for facilitating detection of physiological changes of a subject, the method comprising:\napplying harmonic analysis to the cardiovascular waveform;\nextracting a signal created by ventilation; and\nanalyzing changes in signal strength of the extracted signal to detect changes in blood volume of the subject.\n
analyzing a cardiovascular waveform representing physiological characteristics of a subject using a processor, wherein the analyzing of the cardiovascular waveform includes:\n"],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component of the cardiovascular waveform is a systolic component reflective of a cardiovascular impact of respiration on per cardiac-cycle maximums of the cardiovascular waveform."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component of the cardiovascular waveform is a diastolic component reflective of a cardiovascular impact of respiration on per cardiac-cycle minimums of the cardiovascular waveform."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component of the cardiovascular waveform is reflective of a cardiovascular impact of respiration on per heart-beat dicrotic notches of the cardiovascular waveform."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component of the cardiovascular waveform is an arterial component reflective of a cardiovascular impact of respiration on an amplitude of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the arterial component are indicative of changes in arterial blood volume of the subject."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component of the cardiovascular waveform is a venous component reflective of a cardiovascular impact of respiration on a baseline of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the venous component are indicative of changes in venous blood volume of the subject."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the cardiovascular waveform is analyzed in at least one of (i) the time domain, (ii) the frequency domain and (iii) the joint time-frequency domain."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the analyzed characteristic is reflective of at least one of (i) changes in per respiratory-cycle maximums of the first component in the time domain, (ii) changes in per respiratory-cycle minimums of the first component in the time domain, and (iii) changes in a difference between corresponding per respiratory-cycle maximums and per respiratory-cycle minimums of the first component in the time domain; and (iv) changes in a signal strength of the first component in the frequency domain."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the cardiovascular waveform is analyzed using harmonic analysis to identify the first component of the cardiovascular waveform."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein the identifying the first component of the cardiovascular waveform is achieved using a peak detection algorithm on the cardiovascular waveform applied in the frequency domain."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein the first component of the cardiovascular waveform is an arterial component reflective of a cardiovascular impact of respiration on an amplitude of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the arterial component are identified based on side bands surrounding a primary cardiac signal component in the cardiac frequency range, and wherein the amplitude variations of the arterial component are indicative of changes in arterial blood volume of the subject."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 21, wherein the first component of the cardiovascular waveform is a venous component reflective of a cardiovascular impact of respiration on a baseline of a cardiac-signal component of the cardiovascular waveform, wherein the venous component is identified in the respiratory frequency range, and wherein the amplitude variations of the venous component are indicative of changes in venous blood volume of the subject."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component is normalized based on an amplitude of a cardiac signal component of the cardiovascular waveform."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the analyzing the characteristic of the first component of the cardiovascular waveform includes calculating an index responsive to the amplitude variations of the first component, wherein index variations are indicative of physiological changes in the subject."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising monitoring fluid responsiveness of the subject based on the analysis of the characteristic of the first component."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising detecting hypovolemia based on the analysis of the characteristic of the first component."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, further comprising detecting dehydration based on the analysis of the characteristic of the first component."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein subject respiration is synchronized with a metronome."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein airway pressure is at least one of (i) actively controlled and (ii) standardized."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 13, wherein the first component is normalized based on one of (i) respiratory oscillations and (ii) airway pressure."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["A system for assessing changes in blood volume within a subject, the system comprising:\nidentifying a first component of the cardiovascular waveform reflective of a cardiovascular impact of respiration; and\nanalyzing a characteristic of the first component reflective of amplitude variations of the first component, wherein the amplitude variations are indicative of changes in blood volume of the subject.\n
a probe adapted for generating a cardiovascular waveform of a subject; and\n
a processor configured for analyzing the cardiovascular waveform to determine changes in blood volume of the subject, wherein the analyzing of the cardiovascular waveform includes:\n"],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the probe is photoplethysmographic device and the cardiovascular waveform is a photoplethysmograph waveform."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the harmonic analysis includes Fourier analysis."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the harmonic analysis includes joint time-frequency analysis."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 36, wherein the harmonic analysis includes a short-time Fourier transformation."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the extraction of the signal is achieved using a peak detection algorithm."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 38, wherein the peak detection algorithm is applied in the frequency range of ventilation."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the determining the changes in blood volume includes monitoring a signal in a respiratory frequency range to ascertain changes in a venous component of blood volume."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein the determining the changes in blood volume includes monitoring side bands surrounding a signal in a cardiac frequency range to ascertain changes in the arterial component of the blood volume."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The system according to claim 33, wherein ventilation of the subject is synchronized with a metronome."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["A system for facilitating detection of physiological changes of a subject, the system comprising:\napplying harmonic analysis to the cardiovascular waveform;\nextracting a signal created by ventilation; and\napplying the extracted signal in determining the changes in blood volume of the subject, wherein the applying the extracted signal includes monitoring changes in a signal strength of the extracted signal in the frequency domain.\n
a probe adapted for generating a cardiovascular waveform representing physiological characteristics of a subject; and\n
a processor configured for analyzing the cardiovascular waveform, wherein the analyzing the cardiovascular waveform includes identifying a first component of the cardiovascular waveform reflective of a cardiovascular impact of respiration, and analyzing a characteristic of the first component reflective of amplitude variations of the first component, wherein the amplitude variations are indicative of changes in blood volume of the subject."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component of the cardiovascular waveform is a systolic component reflective of a cardiovascular impact of respiration on per cardiac-cycle maximums of the cardiovascular waveform."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component of the cardiovascular waveform is a diastolic component reflective of a cardiovascular impact of respiration on per cardiac-cycle minimums of the cardiovascular waveform."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component of the cardiovascular waveform is reflective of a cardiovascular impact of respiration on per heart-beat dicrotic notches of the cardiovascular waveform."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component of the cardiovascular waveform is an arterial component reflective of a cardiovascular impact of respiration on an amplitude of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the arterial component are indicative of changes in arterial blood volume of the subject."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component of the cardiovascular waveform is a venous component reflective of a cardiovascular impact of respiration on a baseline of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the venous component are indicative of changes in venous blood volume of the subject."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the cardiovascular waveform is analyzed in at least one of (i) the time domain, (ii) the frequency domain and (iii) the joint time-frequency domain."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the analyzed characteristic is reflective of at least one of (i) changes in per respiratory-cycle maximums of the first component in the time domain, (ii) changes in per respiratory-cycle minimums of the first component in the time domain, and (iii) changes in a difference between corresponding per respiratory-cycle maximums and per respiratory-cycle minimums of the first component in the time domain; and (iv) changes in a signal strength of the first component in the frequency domain."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the cardiovascular waveform is analyzed using harmonic analysis to identify the first component of the cardiovascular waveform."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 51, wherein the identifying the first component of the cardiovascular waveform is achieved using a peak detection algorithm on the cardiovascular waveform applied in the frequency domain."],"number":52,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 51, wherein the first component of the cardiovascular waveform is an arterial component reflective of a cardiovascular impact of respiration on an amplitude of a cardiac-signal component of the cardiovascular waveform, wherein the amplitude variations of the arterial component are identified based on side bands surrounding a primary cardiac signal component in the cardiac frequency range, and wherein the amplitude variations of the arterial component are indicative of changes in arterial blood volume of the subject."],"number":53,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 51, wherein the first component of the cardiovascular waveform is a venous component reflective of a cardiovascular impact of respiration on a baseline of a cardiac-signal component of the cardiovascular waveform, wherein the venous component is identified in the respiratory frequency range, and wherein the amplitude variations of the venous component are indicative of changes in venous blood volume of the subject."],"number":54,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component is normalized based on an amplitude of a cardiac signal component of the cardiovascular waveform."],"number":55,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the analyzing the characteristic of the first component of the cardiovascular waveform includes calculating an index responsive to the amplitude variations of the first component, wherein index variations are indicative of physiological changes in the subject."],"number":56,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the analyzing the cardiovascular waveform further includes monitoring fluid responsiveness of the subject based on the analysis of the characteristic of the first component."],"number":57,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the analyzing the cardiovascular waveform further includes detecting hypovolemia based on the analysis of the characteristic of the first component."],"number":58,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the analyzing the cardiovascular waveform further includes detecting dehydration based on the analysis of the characteristic of the first component."],"number":59,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, further comprising a metronome adapted for synchronizing subject respiration."],"number":60,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, further comprising an airway pressure control adapted for at least one of (i) actively controlling airway pressure and (ii) standardizing airway pressure."],"number":61,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 43, wherein the first component is normalized based on one of (i) respiratory oscillations and (ii) airway pressure."],"number":62,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}