{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"141-000-272-512-038","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"141-000-272-512-038"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11685,"type":"PATENT","title":"Erasmus University Rotterdam - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1765,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8341,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
Search Applicants and Owners separately:univ* AND Montpellier. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1289
Search Applicants and Owners separately: queen* AND univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1261
Search Applicants and Owners separately:univ* AND Montpellier. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1289
detecting the presence of a sclerostin gene region nucleotide polymorphism in a biological sample from a female subject, said sample comprising DNA comprising at least 50 consecutive nucleotides that are present in SEQ ID NO: 1, wherein the polymorphism is a GGA trinucleotide insertion between positions 10565 and 10566 in SEQ ID NO: 1 or the complement thereof, wherein the presence of said polymorphism indicates an increased risk of decreased bone mineral density in female subjects aged 71-80 years."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the detecting step comprises:\n
contacting the biological sample with at least one oligonucleotide primer selected from the group consisting of SEQ ID NO: 8 and SEQ ID NO: 9, under conditions and for a time sufficient to allow hybridization of said primer to the DNA."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the biological sample is selected from the group consisting of blood, biopsy specimen, tissue explant, organ culture and tissue sample."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, further comprising:\n
detecting hybridization and extension of the oligonucleotide primer to produce a product, and therefrom determining the presence the polymorphism."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of 1, wherein the DNA in the sample is amplified."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, further comprising diagnosing the subject as having an increased risk of osteoporosis."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, further comprising monitoring bone mineral density clinical parameters of the subject."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, further comprising treating said female subject with an agent for treating decreased bone mineral density."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 wherein the agent is selected from the group consisting of estrogen, calcium, vitamin D, calcitonin, bisphosphonates, anabolic steroids and sodium fluoride."],"number":9,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}