{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"134-832-950-163-155","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"134-832-950-163-155","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":6804,"type":"PATENT","title":"Univ Sydney Patent Portfolio","description":"Searched ' Univ Sydney ' for patent collection. Added owners (US), expanded by simply family and date range set as 01/Jan/2000 - 01/ Apr/ 2015\n","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":47811,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[],"sharedType":"PUBLISHED","hasLinkedSavedQueries":false,"savedQueries":[],"created":"2015-05-04T02:51:05Z","updated":"2015-05-04T04:00:52Z","lastEventDate":"2015-05-04T04:00:52Z"},{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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(1) -(CH2),C(R10, R2a)N(R4a, R5a),
(2) H,
(3) ―(CH2)r(R1a,R2a)(CH2),OR3a
(4) ―(CH2)C(R1a,R2a)N(R4a)COR3a,
(5) ―(CH2),C(R1a,R2a)NHCON(R4a,R5a),
(6) ―(CH2,C(R1a,R2a)NHC(=NH)N(R4a,R5a),
(7) ―CH(R1a,R2a),
(8) ―CmCH,
(9) ―(CH2),C(R1a,R2a)CN,
(10) ―(CH2),C(R1a,R2a)CO2R3a, and
(11) ―(CH2),c(R1a,R2a)CN(R4a,R5a), wherein R1a R2a, R3a R4a, and R5a are independently selected from the group consisting ofE is absent or selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C6-alky1,(c) subtitituted or unsubstituted aryl,(d) substituted or unsubstituted heterocycly1,(e) substituted or unsubstituted heteroary1,(f) C1-C6-alky1 substituted with ary1,(g) C1-C6alkyl substituted with heterocyclyl, and(h) C1-C6-alkyl substituted with heteroaryl, or R4atogether with the N atom to which they are attached can form a substituted or unsubstituted heterocyclic ring, having from 3 to 8 ring atoms, Wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S;T is an integer of 0-4; s is an integer of 0-4;
(1) H.
(2) substituted or unsubstituted C1-C6-alkyl,
(3) substituted or unsubstituted C2-C6-alkenyl,
(4) substituted or unsubstituted C2-C6-alkynyl,
(5) substituted or unsubstituted aryl;
(6) substituted or unsubstituted heterocyclyl
(7) substituted or unsubstituted heteroaryl ;L is absent or selected from the group consisting of
(1) substituted or unsubstitiued C1-C6-alkyl,
(2) ―(NH)0-1-(CH2),-NR3L-(CH2)-
(3) ―(NH)0-1-C(R1L: R2L)-C(R1L,R2L)-
(4) ―C(R1L, R2L)-O-C(R1L, R2L)-,
(5) ―(CH2),-NR3L-C(R1L,R2L)-CONH-(CH2)-
(6) ―CO.-C(R1L,R2L)-NHCO-,
(7) ―CONH-,
(8) ―NHCO-, wherein R1L, R2L, and R3L are independently selected from the group consisting ofD is absent or selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C6-alkyl.(c) C1-C6-alkyl substituted with aryl.(d) C1-C6-alkyl substituted with heterocyclyl, and(e) C1-C6-alkyl substituted with heteroaryl.or R1L and R3L together with the atoms to which they are attached can from a substituted or unsubstituted heterocyclic ring, having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system, are selected from N, O and S, j is an integer of 0-4; k is an integer of 0-4;
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted hetemaryl;Gs absent or selected from the groups consisting of
(1) ―(CH2)-O-(CH2)-
(2) ―(CH2)-S-(CH2)-,
(3) ―(CH2)-NR8-(CH2)-,
(4) ―C(=0)-,
(5) ―NHC(=0)-,
(6) ―C(=O)NH-,
(7) ―(CH2)1NHCH2C(=O)NH-,
(8) ―C=C-,
(9) ―C=C-C=C-, and
(10) ―C-C-; wherein RE is H or substituted or unsubsituted C1-C6-alkyl; i is an integer of 0-4Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalky1,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C-O)-
(2) ―C1-C6-alky1-(c=o)-,
(3) ―C2-C6-alkenyl-(C=0)-,
(4) ―C2-C6-alkynyl-(C=O)-, and
(5) ―CH2-; or when B is absent, X and A, together with the atoms to which they are attached can form a heterocyclic ring, having from 5 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S;B is a absent or
wherein R1b and R2b are independently selected from the group consisting ofR3 is H or substituted or unsubstituted C1-C6-alkyl,(a) H,(b) substituted or unsubstituted C1-C6-alkyl,(c) substituted or unsubstituted C2-C6-alkenyl,(d) substituted or unsubstituted C2-C6-alkynyl,(e) substituted or unsubstituted aryl,(f) substituted or unsubstituted heterocyclyl,(g) substituted or unsubstituted heteroaryl,(h) C1-C6-alkyl substituted with aryl,(i) C1-C6-alkyl substituted with heterocyclyl, and(j) C1-C6-alkyl substituted with heteroaryl,or R1b and R2b, together with the atoms to which they are attached can form a substituted or unsubstituted heterocyclic ring, having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S; q is an integer of 0-4;
or R3 and A, together with the atoms to which they are attached can form a substituted or unsubstituted 3-10 membered cycloalkyl or a heterocyclic ring system, wherein the heterocyclic ring system may have from 3 to 10 ring atoms,with 1 to 2 rings being in the ring system and contain from 1-4 heteroatoms selected from N, O and S;R4 is H or substituted or unsubstituted C1-C6-alkyl,
or R4 and A, together with the atoms to which they are attached can form a substituted or unsubstituted heterocyclic ring, having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N,0 and S;n is an integer of 0-2; Q is absent or selected from the group consisting of
(1) ―C(-O)N(R1,R2),
(2) ―NHC(-O)N(R1,R2),
(3) ―N(OH)C(=0)N(R1R2),
(4) ―CH(OH)C(=O)N(R1,R2).
(5) ―CH[N(R2q,R3q)]C(-O)N(R1,R2).
(6) ―CBR1qC(=O)N(R1,R2).
(7) ―CO2H,
(8) ―C(=O)NHSO2R4q,
(9) ―SO2NH2,
(10) ―N(OH)C(=0)R1q,
(11) ―N(OH)SO2R4q,
(12) ―NRSO2R4q,
(13) ―SH
(14) ―CH(SH)(CH2)0-1C(=0)N(R1,) R2).
(15) ―CH(SH)(CH2)0-1CO2H,
(16) ―CH(OH)(CH2)0-1CO2H,
(17) ―CH(SH)CH2CO2R1q,
(18) ―CH(OH)(CH2)SO2NH2,
(19) ―CH(CH2SH)NHCOR1q,
(20) ―CH(CH2SH)NHS02R4q,
(21) ―CH(CH2SR5q)CO2H,
(22) ―CH(CH2SH)NHSO2NH2,
(23) ―CH(CH2OH)CO2H,
(24) ―CH(CH2SH)NHSO2NH2,
(25) ―C(-O)CH2CO2H,
(26) ―C(-O)(CH2CH)0-1CONH2,
(27) ―oSO2NHR5q,
(28) ―SO2NHNH2,
(29) ―P(-O)(OH)2,
(30)
(31) and
(32)R1 is selected from the group consisting of
(1) ―H,
(2) ―OH,
(3) ―OC1-6-alky1,
(4) ―N(R2q,R3q), and
(5) substituted or unsubstituted C1-6-alkyl;R2 is selected from the group consisting of
(1) H,
(2) substituted or unsubstituted C1-C6-alkyl,
(3) substituted or unsubstituted C2-C6-alkenyl,
(4) substituted or unsubstituted C2-C6-alkenyl,
(5) substituted or unsubstituted aryl,
(6) substituted or unsubstituted heterocyclyl,
(7) substituted or unsubstituted heteroaryl,
(8) C1-C6-alkyl substituted with aryl,
(9) C1-C6-alkyl substituted with heterocyclyl, and
(10) C1-C6-alkyl substituted with heteroaryl, or R1 and R2, together with the N atom to which they are attached can form a substituted or unsubstituted heterocycylic ring having from 3 to 10 ring atoms, wherein 1-4 ring atoms of the heterocyclic ring system are selected from N,O and S, R1q, R2q, R3q,R4q,and R5q are selected from H or C1-C6 alkyl,wherein B is absent, or E, L, G, and B are absent, or E, L, and G are absent, or E, L, and B are absent, or E,L,D,G, and B are absent."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 according to the formula I-A: or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein D is selected from the group consisting of
(1) substituted or unsubstituted C8-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;G is selected from the group consisting of
(1) ―(CH2),-O-(CH2),-
(2) ―(CH2),-S-(CH2),-,
(3) ―(CH2),NR9-(CH2),-,
(4) ―C(=O)-,
(5) ―NHC(=O)-,
(6) ―C(=O)NH-,
(7) ―(CH2)iNHCH2C(=O)NH-,
(8) ―CΞC-,
(9) ―CΞC-CΞC-, and
(10) ―C=C-, wherein R9 is H or substituted or unsubstituted C1-C8-alkyl and i is an integer of 0-4;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)-,
(2) ―C1-C8-alkyl-(C=O,
(3) ―C2-C6-alkenyl-(C=O)-,
(4) ―C2-Ce-alkynyl-(C=O)-, and
(5) ―CH2-;Ra is H or substituted or unsubstituted C1-C6-alkyl; R4 is H or substituted or unsubstituted C1-C6-alkyl; R1a and R2a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl; andR4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl, or R4a and R5a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 2. wherein D is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl.
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;G is selected from the group consisting of
(1) ―C(=O)-,
(2) ―NHC(=O)-,
(3) ―C(=O)NH-,
(4) ―(CH2)1NHCH2C(=O)NH-,
(5) ―CΞC-, and
(6) ―CΞC-CΞC-, wherein i is an integer of 0-4;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)-
(2) ―C1-C8-alkyl-(C=O)-,
(3) ―C2-C8-alkenyl-(C=O)-,
(4) ―C2-C8-alkynyl-(C=O)-, and
(5) ―CH2-;R3 is H or substituted or unsubstituted C1-C6-alkyl; R4 is H or substituted or unsubstituted C1-C6-alkyl; R1a and 2a are independently selected from the group consisting of
(a) H.
(b) substituted or unsubstituted C1-C6-alkyl,
(c) C1-C6-alkyl substituted with aryl,
(d) C1-C6-alkyl substituted with heterocyclyl, and
(e) C1-C6-alkyl substituted with heteroaryl; andR4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl.
(f) C1C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl, or R4a and R6a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 5 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A compound according to claim 2 or claim 3, or a stereoisomor, pharmaceutically acceptable salt, or ester thereof, wherein D-G-Y, taken together, is selected from the group consisting of and
wherein R is selected from the group consisting of -CH3, -C2H6, -CH2OH, -OH, -OCH3, -OC2H5, -OCF3. -CN, -NO2 -CO2H, -CO2CH3. -CONH2, -NH2, -F, - Cl, -Br, -CF3, -N(CH3)2, -NHSO2CH3, and -NHCOCH3;X is selected from the group consisting of
(1) ―(C=O)-,
(2) ―C1-C8-alkyl-(C=O)-, and
(3) ―C2-C8-alkenyl-(C=O)-; andR1a, R2A, R4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A compound according to any one of claims 2 to 4, wherein R4a and R5a are hydrogen."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A compound according to any one of claims 2 to 4, wherein R1a and R2aare independently selected from hydrogen and methyl."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A compound according to any one of claims 2 to 6, wherein X is -(C=O)-."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 according to the formula I-B: or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein D is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)-,
(2) ―C1-C8-alkyl-(C=O)-,
(3) ―C2-C8-alkenyl-(C=O)-,
(4) ―C2-C6-alkynyl-(C=O)-, and
(5) ―CH2-:R3 is H or substituted or unsubstituted C1-C6-alkyl; R4 is H or substituted or unsubstituted C1-C6-alkyl; R1a and R2a are independently selected from the group consisting of
(a) N,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl; andR4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C6-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl, or R4a and R5a together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 8, wherein D Is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C6-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)―,
(2) ―C1-C8-alkyl-(C=O)―,
(3) ―C2-C8-alkenyl-(C=O)―
(4) ―C2-C8-alkynyl-(C=O)―, and
(5) ―CH2―;R3 is H or substituted or unsubstituted C1-C8-alkyl; R4 is H or substituted or unsubstituted C1-C8-alkyl; R1a and R2a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl.
(c) C1-C8-alkyl substituted with aryl,
(d) C1-C8-alkyl substituted with heterocyclyl, and
(e) C1-C6-alkyl substituted with heteroaryl; andR4a and R5a are Independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl, or R48 and R6a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 5 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 according to the formula I-C: or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)―,
(2) ―C1-C8-alkyl-(C=O)―,
(3) ―C2-C8-alkenyl-(C=O)―,
(4) ―C2-C8-alkynyl-(C=O)―, and
(5) ―CH2-;R3 is H or substituted or unsubstituted C1-C8-alkyl; R4 is H or substituted or unsubstituted C1-C8-alkyl; R1a and R2a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl; andR4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl, or R4a and R6a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 according to the formula I-D: or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein E is selected from the group consisting of
(1) H,
(2) substituted or unsubstituted C1-C8-alkyl,
(3) substituted or unsubstituted C2-C8-alkenyl,
(4) substituted or unsubstituted C2-C8-alkynyl,
(5) substituted or unsubstituted aryl,
(6) substituted or unsubstituted heterocyclyl, and
(7) substituted or unsubstituted heteroaryl;L is selected from the group consisting of
(1) substituted or unsubstituted C1-C6-alkyl,
(2) ―(NH)0.1―C(CH2)―NR3L―(CH2)k―,
(3) ―(NH)0.1―C(R1L, R2L)―NR3L―C(R1L, R2L)―,
(4) ―C(R1L, R2L)―O―C(R1L, R2L)―,
(5) ―(CH2),―NR3L―C(R1L, R2L)―CONH―(CH2)k―,
(6) ―CO―C(R1L, R2L)―NHCO―,
(7) ―CONH―, and
(8) ―NHCO―, wherein R1L and R3L are independently selected from the group consisting ofD is selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C8-alkyl,(c) C1-C8-alkyl substituted with aryl,(d) C1-C8,-alkyl substituted with heterocyclyl, and(e) C1-C8-alkyl substituted with heteroaryl, or R1L and R3L, together with the atoms to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S;R2L is selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C8-alkyl,(c) C1-C8-alkyl substituted with aryl,(d) C1-C8-alkyl substituted with heterocyclyl, and(e) C1-C8-alkyl substituted with heteroaryl;j is an Integer of 0-4; and k is an integer of 0-4;
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;G is selected from the group consisting of
(1) ―(CH2)―O―(CH2)―,
(2) ―(CH2)―S―(CH2)―
(3) ―(CH2)―NR9(CH2)―,
(4) ―C(=O)―.
(5) ―NHC(=O)―,
(6) ―C(=O)NH―,
(7) ―(CH2)1NHCH2C(=O)NH―,
(8) ―C=C―,
(9) ―C≡C―C≡C―, and
(10) ―C=C―; wherein R9 is H or substituted or unsubstituted C1-C6-alkyl and i is an integer of 0-4;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)―.
(2) ―C1-C6-alkyl-(C=O)―,
(3) ―C2-C6-alkenyl-(C=O)―
(4) ―C2-C8-alkynyl-(C=O)―, and
(5) ―CH2―;R3 is H or substituted or unsubstituted C1-C8-alkyl; R4 is H or substituted or unsubstituted C1-C6-alkyl; R1a and R2a are independently selected from the group consisting of
(a) H.
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl; andR4a and R5a are Independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl, or R4a and R5a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 6 ring atoms wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 11, wherein E is selected from the group consisting of
(1) H,
(2) substituted or unsubstituted C1-C8-alkyl,
(3) substituted or unsubstituted aryl,
(4) substituted or unsubstituted heterocyclyl, and
(5) substituted or unsubstituted heteroaryl;L is selected from the group consisting of
(1) ―C(CH2)―NR3L―(CH2)k―,
(2) ―C(R1L, R2L)―NR3L―C(R1L, R2L)―,
(3) ―C(R1L, R2L)―O―C(R1L, R2L)―,
(4) ―(CH2)―NR3L―C(R1L, R2L)―CONH―(CH2)k―,
(5) ―CO―C(R1L R2L)―NHCO―,
(6) ―CONH―, and
(7) ―NHCO―, wherein R1L and R3L are independently selected from the group consisting ofD is selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C8-alkyl,(c) C1-C8-alkyl substituted with aryl,(d) C1C8-alkyl substituted with heterocyclyl, and(e) C1-C8-alkyl substituted with heteroaryl, or R1L and R3L, together with the atoms to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 5 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S;R2L is selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C6-alkyl,(c) C1-C8-alkyl substituted with aryl,(d) C1-C8-alkyl substituted with heterocyclyl, and(e) C1-C8-alkyl substituted with heteroaryl;j is an integer of 0-4; and k is an integer of 0-4;
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;G is selected from the group consisting of
(1) ―C(=O)―,
(2) ―NHC(=O)―,
(3) ―C(=O)NH―,
(4) ―(CH2)1NHCH2C(=O)NH―.
(5) ―C=C―, and
(6) ―C=C―C=C―, wherein i is an integer of 0-4;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)―,
(2) ―C1-C8-alkyl-(C=O)―,
(3) ―C2-C8-alkenyl-(C=O)―,
(4) ―C2-C8-alkynyl-(C=O)―, and
(5) ―CH2-;R3 is H or substituted or unsubstituted C1-C8-alkyl; R4 is H or substituted or unsubstituted C1-C8-alkyl; R1a and R2a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) C1-C8-alkyl substituted with aryl,
(d) C1-C8-alkyl substituted with heterocyclyl, and
(e) C1-C8-alkyl substituted with heteroaryl; andR4a and R5a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl.
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl, or R4a and R5a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 5 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 1 according to the formula I-E: or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, wherein D Is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl,X is selected from the group consisting of
(1) ―(C=O)―,
(2) ―C1-C8-alkyl-(C=O)―,
(3) ―C2C8-alkenyl-(C=O)―,
(4) ―C2-C8-alkynyl-(C=O)―. and
(5) ―CH2―;B is
wherein R1b and R2b, are Independently selected from the group consisting ofR3 is H or substituted or unsubstituted C1-C8-alkyl ; R4 is H or substituted or unsubstituted C1-C8-alkyl; R1a and R2a are independently selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C8-alkyl,(c) substituted or unsubstituted C2-C8-alkenyl.(d) substituted or unsubstituted C2-C8-alkynyl,(e) substituted or unsubstituted aryl,(f) substituted or unsubstituted heterocyclyl,(g) substituted or unsubstituted heteroaryl,(h) C1-C8-alkyl substituted with aryl,(i) C1-C8-alkyl substituted with heterocyclyl, and(j) C1-C8-alkyl substituted with heteroaryl,or R1b and R2b, together with the atoms to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N. O and S; and q is an Integer of 0-4;
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl.
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl; andR4a and R5a are Independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl,
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C6-alkyl substituted with heterocyclyl, and
(h) C1-C6-alkyl substituted with heteroaryl, or R4a and R5a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 3 to 8 ring atoms wherein 1-2 ring atoms of the heterocyclic ring system are selected from N O and S."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A compound of claim 13, wherein D is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;Y is selected from the group consisting of
(1) substituted or unsubstituted C3-C8-cycloalkyl,
(2) substituted or unsubstituted aryl,
(3) substituted or unsubstituted heterocyclyl, and
(4) substituted or unsubstituted heteroaryl;X is selected from the group consisting of
(1) ―(C=O)―,
(2) ―C1-C8-alkyl-(C=O)―,
(3) ―C2-C8-alkenyl-(C=O)―,
(4) ―C2-C8-alkynyl-(C=O)-, and
(5) ―CH2―,B is
wherein R1b and R-, are independently selected from the group consisting ofR3 is H or substituted or unsubstituted C1-C8-alkyl; R4 is H or substituted or unsubstituted C1-C8-alkyl; R1a and R2a are Independently selected from the group consisting of(a) H,(b) substituted or unsubstituted C1-C6-alkyl,(c) substituted or unsubstituted C2-C6-alkenyl,(d) substituted or unsubstituted C2-C8-alkynyl,(e) substituted or unsubstituted aryl,(f) substituted or unsubstituted heterocyclyl,(g) substituted or unsubstituted heteroaryl,(h) C1-C8 -alkyl substituted with aryl,(i) C1-C8-alkyl substituted with heterocyclyl, and(j) C1-C6-alkyl substituted with heteroaryl,or R1b and R2b, together with the atoms to which they are attached can form a substituted or unsubstituted heterocyclic ring, having from 3 to 8 ring atoms, wherein 1-2 ring atoms of the heterocyclic ring system are selected from N, O and S; and q is an integer of 0-4;
(a) H,
(b) substituted or unsubstituted C1-C6-alkyl,
(c) C1-C8-alkyl substituted with aryl,
(d) C1-C8-alkyl substituted with heterocyclyl, and
(e) C1-C8-alkyl substituted with heteroaryl; andR4a and R6a are independently selected from the group consisting of
(a) H,
(b) substituted or unsubstituted C1-C8-alkyl
(c) substituted or unsubstituted aryl,
(d) substituted or unsubstituted heterocyclyl,
(e) substituted or unsubstituted heteroaryl,
(f) C1-C8-alkyl substituted with aryl,
(g) C1-C8-alkyl substituted with heterocyclyl, and
(h) C1-C8-alkyl substituted with heteroaryl, or R4a and R5a, together with the N atom to which they are attached, form a substituted or unsubstituted heterocyclic ring having from 5 to 8 ring atoms wherein 1-2 ring atoms of the heterocyclic ring system are selected from N O and S."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound from one of claims 2-14 and a pharmaceutically acceptable excipient."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound from one of claims 2-14, a second agent, and a pharmaceutically acceptable excipient."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["A compound of any one of claims 2-14 for treating a bacterial infection,"],"number":17,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}