{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"131-393-523-218-990","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"131-393-523-218-990"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10795,"type":"PATENT","title":"The Ohio State University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7061,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8260,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"ohio state univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5396
Search Applicants and Owners separately: \"ohio state univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 5396
1) exhibits antagonist activity;\n
2) binds to prolactin receptor through site 1;\n
3) does not bind to prolactin receptor through site 2 or has diminished binding through site 2; and\n
4) exhibits less than 1% of unmodified prolactin's agonist activity;\nwherein the prolactin molecule comprises at least one mutation in a region selected from i) amino acids 41–57, ii) amino acids 94–110, and iii) amino acids 160–173; and wherein the at least one mutation is selected from deletions, replacements, and insertions."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The modified human prolactin molecule according to claim 1, wherein the prolactin molecule exhibits less than 0.9% of unmodified prolactin's agonist activity."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The modified human prolactin molecule according to claim 2, wherein the prolactin molecule exhibits less than 0.5% of unmodified prolactin's agonist activity."],"number":3,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}