{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"125-473-130-441-06X","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"125-473-130-441-06X"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12026,"type":"PATENT","title":"Boston College Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":531,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8582,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:boston college. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 511
Search Applicants and Owners separately:boston college. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 511
wherein\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["2.-32. (canceled)"],"number":-1,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein\nX is O, NR4, S or absent;\nR1, and R2 are independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\neach R3 is independently halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\nR4 is hydrogen or C1-4 alkyl;\nm is an integer 0 to 2, inclusive.\n
R1 is optionally substituted C1-6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl; and\n
R2 is optionally substituted aryl, or optionally substituted heteroaryl."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein X is S."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein m is 0."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein\n
R1 is optionally substituted C1-6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;\n
R2 is optionally substituted aryl, or optionally substituted heteroaryl;\n
X is S; and\n
m is 0."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The compound of claim 1, wherein the compound is selected from the group consisting of:"],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["A method for treating a subject with low cortisol levels, adrenal insufficiency, or a disease or disorder-associated with adrenal insufficiency, the method comprising administering to the subject a therapeutically effective amount of a composition comprising at least one compound of formula (I) according to claim 1."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, further comprising administering a second compound selected from the groups of formula (II)-(VI), wherein the compound of formula (II) is:\n
wherein\n\n\neach R1, and R3 is independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; or substituted or unsubstituted, branched or unbranched alkylaryl;\nR2, R4 and R5 is independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo; and\n\nwherein a compound of formula (III) is:\n
wherein\n\n\neach R1 is independently halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\nR2 is hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; or substituted or unsubstituted, branched or unbranched alkylaryl;\nm is an integer 0 to 4, inclusive; and\n\nwherein a compound of formula (IV) is:\n
wherein\n\n\nwherein\nR1 and R3 is independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; or substituted or unsubstituted, branched or unbranched alkylaryl;\nR2, R4, and R5 is independently halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo; and\nwherein a compound of formula (V) is:\n
R1, and R3 are independently hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo or\n\n
each R2 is independently halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\n
n is an integer 0 to 4, inclusive; and\nwherein the compound of formula (VI) is:\nwherein\n
X is O, NR4, S or absent;\n
R1, R3 and R4 are independently, hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\n
each R2 is independently halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted, branched or unbranched aryl; substituted or unsubstituted, branched or unbranched heteroaryl; —C(═O)RB; —CO2RB; -; —CN; —SCN; —SRB; —SORB; —SO2RB; —NO2; —N(RB)2; —NHC(O)RB; or C(RB)3; wherein each occurrence of RB is independently hydrogen; halogen; a protecting group; aliphatic; heteroaliphatic; acyl; aryl moiety; heteroaryl; hydroxyl; aloxy; aryloxy; alkylthioxy; arylthioxy; amino; alkylamino; dialkylamino; heteroaryloxy; heteroarylthioxy; or alkylhalo;\n
n is an integer 0-2, inclusive."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein a compound of formula (II) is selected from the group consisting of:"],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein a compound of formula (III) is selected from the group consisting of:"],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein the compound of formula (IV) is selected from the group consisting of:"],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 39, wherein a compound of formula (V) has the following structure:"],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein a compound of formula (VI) has the following structure:"],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the subject is identified as having adrenal insufficiency prior to administering the composition comprising a compound of any of formula (I) to the subject."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the subject has been tested for and determined to have at least one of the following characteristics: a plasma cortisol level of less than about 140 nmol/L at between 8:00-10:00 am in the morning, a plasma cortisol level of less than about 80 nmol/L at about midnight, or a urine cortisol level of less than about 28 nmol/24 hrs."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the compound of formula (I) comprises at least one of:\n
R1 is optionally substituted C1-6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;\n
R2 is optionally substituted aryl, or optionally substituted heteroaryl;\n
X is S; or\n
m is 0."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 47, wherein the compound of formula (I) comprises:\n
R1 is optionally substituted C1-6 alkyl, optionally substituted aryl, or optionally substituted heteroaryl;\n
R2 is optionally substituted aryl, or optionally substituted heteroaryl;\n
X is S; and\n
m is 0."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the subject has cancer, or an inflammation associated disorder or an allergic condition, or a disease associated with adrenal insufficiency selected from the group consisting of: inflammation, Addition's disease, Nelson's disease, autoimmune adrenalitis, congenital hyperplasia, adrenoma of the adrenal gland, impairment of the pituitary gland, impairment of the hypothalamus, hypoadrenia, allergic reaction, autoimmune disease."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 47, wherein the inflammatory condition or inflammation associated disorder is selected from the group consisting of: rheumatoid arthritis, systemic lupus, acute gouty arthritis, psoriatic arthritis, ulcerative colits, Crohn's disease, a chronic skin condition, bronchial asthma, allergic rhinitis, drug-induced dermatitis, contact and atopic dermatitis, dermatitis herpeiformis, pemphigus, severe psoriasis, and seborrheic dermatitis."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 47, wherein the subject has a cancer selected from the group consisting of: blood cell cancer, lymph gland cancer, leukemia, lymphoma, acute lympoblastic leukemia, prostate cancer and adrenal cancer; or an autoimmune disease or disorder selected from the group consisting of: idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, thyroiditis and sarcoidosis."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 38, wherein the subject is a human neonate, infant or child."],"number":52,"annotation":false,"title":false,"claim":true},{"lines":["A kit comprising a composition one or more compounds compound of formula (I) according to claim 1, and instructions for administration to a subject."],"number":53,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising at least one compound of formula (I) according to claim 1 and a pharmaceutically acceptable carrier."],"number":54,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}