{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"121-229-552-121-293","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"121-229-552-121-293"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11626,"type":"PATENT","title":"National University of Singapore - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4868,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8301,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: nat* univ* AND sing*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4132
Search Applicants and Owners separately: colorado state uni*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1775
Search Applicants and Owners separately: nat* univ* AND sing*
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Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4132
Search Applicants and Owners separately: colorado state uni*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1775
the antigen binding protein does not substantially bind a mannose oligosaccharide, a phosphoinositol mannoside (PIM), hexose, a pentose monomer, maltotriose, fucose, rhamnose, lactose, galactose, di-arabinan, hexa-arabinan, and/or Nocardia cyriacigeorgica;\n
the cap comprises a plurality of alpha 1-2 linkages, two or more alpha 1-2 linkages, or three or more alpha 1-2 linkages; and/or\n
the ABP binds to an epitope Within the alpha 1-2 linkage mannose cap, optionally wherein the epitope:\n
(a) comprises a region within the alpha 1-2 linkage mannose cap,\n
(b) consists of a region within the alpha 1-2 linkage mannose cap,\n
(c) comprises a plurality of regions within the alpha 1-2 linkage mannose cap,\n
(d) consists of a plurality of regions within the alpha 1-2 linkage mannose cap,\n
(e) comprises the alpha 1-2 linkage mannose cap,\n
(f) comprises one alpha 1-2 linkage mannose cap,\n
(g) comprises a plurality of alpha 1-2 linkage mannose caps,\n
(h) comprises the alpha 1-2 linkage mannose cap and one or more additional alpha 1-2 linkage mannose caps,\n
(i) comprises the alpha 1-2 linkage mannose cap and two or more additional alpha 1-2 linkage mannose caps,\n
(j) comprises the alpha 1-2 linkage mannose cap and three or more additional alpha linkage mannose caps, and/or\n
(k) consists of the alpha 1-2 linkage mannose cap."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The ABP of claim 1, wherein:\n
the antigen binding protein is an antibody or fragment thereof, wherein the antigen binding protein is any of: a monoclonal antibody, a veneered antibody, a CDR-grafted antibody, a variable region fragment, a single domain antibody, a single-chain Fv antibody, a Fab antibody, a Fab′ antibody, a (Fab′)2, antibody; the isotype is IgG1, IgG2, or IgG3; and/or\n
the antigen binding protein is an antibody comprising at least one mutation in the constant region."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A pharmaceutical composition comprising at least one ABP according to claim 1, and a pharmaceutically acceptable excipient."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["An immunoassay device for detecting the presence or absence of a pathogenic mycobacteria in a sample, the device comprising: the ABP according to claim 1 immobilized on a solid support."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["A kit for detecting a pathogenic mycobacteria infection in a sample, the kit comprising the ABP of claim 1 in an amount effective to diagnose the infection, optionally\n
(a) further comprising a container containing the antigen binding protein in a formulation and instructions for use;\n
(b) wherein the ABP consists of the ABP of claim 1;\n
(c) wherein the formulation is present in a vial or an injectable syringe;\n
(d) wherein the antigen binding protein is bound to an array;\n
(e) wherein the antigen binding protein is bound to a lateral-flow type test;\n
(f) wherein the kit is used in an enzyme-linked immunosorbent assay (ELISA);\n
(g) wherein the kit comprises instructions for determining whether the sample contains pathogenic mycobacteria;\n
(h) wherein the kit comprises an agent suitable for detecting the binding between the antigen binding protein and ManLAM;\n
(i) wherein the ABP is immobilized on a solid support; and/or\n
(j) wherein the kit comprises a detectable label."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A solid support linked to the ABP of claim 1."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The ABP of claim 1, wherein the ABP or fragment thereof is capable of competitively inhibiting specific binding to the alpha 1-2 linkage mannose cap of ManLAM, or binding by the ABP of claim 4."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["An isolated antigen binding protein (ABP) or fragment thereof that specifically binds to an alpha 1-2 linkage mannose cap of Mannose-Capped Lipoarabinomannan (ManLAM), wherein the ABP or fragment thereof is a recombinant chimeric ABP and comprises a polypeptide having an amino acid sequence at least 97.4% identical to SEQ ID NO: 15 and an amino acid sequence at least 96.4% identical to SEQ ID NO: 18."],"number":13,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}