{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"117-156-159-785-887","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"117-156-159-785-887","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10780,"type":"PATENT","title":"University of Geneva - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1591,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8250,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Univ* Genev*\"; \"Université de Genève\";
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Search Applicants and Owners separately: univ* AND Leuven;
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Search Applicants and Owners separately: \"Univ* Genev*\"; \"Université de Genève\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 823
Search Applicants and Owners separately: univ* AND Leuven;
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(a) contacting a candidate compound with a functional TRPM4 ion channel;
(b) detecting whether said candidate compound interferes with the function of the TRPM4 ion channel;wherein a compound which inhibits the function of the TRPM4 ion channel is suitable for treating or preventing said neurodegenerative disease."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["In vitro method for identifying a pharmaceutically active compound for treating or preventing a neurodegenerative disease in a subject, comprising
(a) contacting a candidate compound with a cell that expresses a functional TRPM4 ion channel;
(b) detecting whether said candidate compound decreases the transcription of the TRPM4 gene and/or the translation of the TRPM4 mRNA;wherein a compound which decreases the transcription of the TRPM4 gene and/or the translation of the TRPM4 mRNA is suitable for treating or preventing said neurodegenerative disease."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["Method of claim 9 or 10, wherein said neurodegenerative disease is associated with glutamate excitotoxicity."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["Method of claim 11, wherein said neurodegenerative disease is selected from the group consisting of Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["Method of claim 12, wherein said neurodegenerative disease is Multiple Sclerosis."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["Use of
(a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO:1 or SEQ ID NO:2 or a variant thereof having at least 80% sequence identity to the amino acid sequence shown in SEQ ID NO:1 or SEQ ID NO:2; or
(b) a polynucleotide encoding a polypeptide of (a) or the complement thereof for identifying a pharmaceutically active compound for treating or preventing a neurodegenerative disease."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["Use of claim 14, wherein said neurodegenerative disease is selected from the group consisting of Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, preferably Multiple Sclerosis."],"number":15,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}