{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"114-232-307-929-970","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"114-232-307-929-970","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10826,"type":"PATENT","title":"KU Leuven - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7336,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8278,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* AND Leuven;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3165
Search Applicants and Owners separately: univ* AND Leuven;
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3165
(a) obtaining one or more human samples comprising whole blood or a fluid derived from whole blood;\n
(b) comparing a level of oxidized low density lipoprotein (OxLDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in one of the one or more human samples to the level of the OxLDL in a control;\n
(c) comparing a level of malondialdehyde-modified low density lipoprotein (MDA-modified LDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in one of the one or more human samples to the level of the MDA-modified LDL in a control;\n
(d) comparing a level of a heart protein that is a marker for acute myocardial infarction in one of the one or more human samples to the level of the heart protein in a control; and\n
(e) making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b), (c), and (d) are all performed:\n\n1.1 Indication(b)(c)(d)the individual does not have coronary artery disease−−−the individual has chronic coronary artery disease+−−the individual has unstable angina++−the individual has acute myocardial infarction of+++atherosclerotic originthe individual has acute myocardial infarction of−−+non-atherosclerotic origin\nor making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b) and (c) are performed:\n1.2 Indication(b)(c)the individual does not have coronary artery disease−−the individual has chronic coronary artery disease+−the individual has acute coronary artery disease++\nor making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (C) and (d) are performed:\n1.3 Indication(c)(d)the individual does not have acute coronary artery disease−−the individual has unstable angina+−the individual has acute myocardial infarction of−+non-atherosclerotic originthe individual has acute myocardial infarction of++atherosclerotic origin\nwherein “+” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control and “−” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is not higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control, the control providing results based on those of a normal control population."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein at least one of steps (b), (c), and (d) is performed based on the result of an immunological assay."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2 wherein the immunological assay is a competitive assay or a sandwich assay."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2 wherein at least one assay utilizes a monoclonal antibody selected from the group consisting of mAb-4E6, mAb-1H11, mAb-8A2, a monoclonal antibody having a high affinity for a CK-MB or a troponin, and combinations thereof; the monoclonal antibodies mAb-4E6, mAb-1H11, and mAb-8A2 being produced, respectively, by hybridomas Hyb4E6, Hyb1H11, and Hyb8A2, which were deposited on Apr. 24, 1997 at the Belgian Coordinated Collections Of Microorganisms under accession numbers, respectively, of LMBP 1660 CB, LMBP 1659 CB, and LMBP 1661 CB."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein steps (a), (b), (c), and (e) are performed."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein steps (a), (c), (d), and (e) are performed."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein steps (a), (b), (c), (d), and (e) are performed."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein at least one human sample is plasma."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein at least one human sample is serum."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1 wherein the level in the control for each of OxLDL, MDA-modified LDL, and heart protein is representative of the level in a sampling of individuals of a general population who have no history of atherosclerotic cardiovascular disease."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["A method for diagnosing coronary artery disease comprising performing steps (a), (c), and (e) and at least one of steps (b) and (d):\n
(a) obtaining one or more human samples comprising whole blood or a fluid derived from whole blood;\n
(b) performing an immunological assay using mAb-4E6 on one of the one or more human samples and comparing a level of oxidized LDL (OxLDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in the human sample from the assay to the level of the OxLDL in a control; the monoclonal antibody mAb-4E6 being produced by hybridoma Hyb4E6, which was deposited on Apr. 24, 1997 at the Belgian Coordinated Collections Of Microorganisms under accession number LMBP 1660 CB;\n
(c) performing an immunological assay using mAb-1H11 on one of the one or more human samples and comparing a level of malondialdehyde-modified low density lipoprotein (MDA-modified LDL) having at least 60 aldehyde-modified lysine residues per apolipoprotein B-100 (apo B-100) moiety in the human sample from the assay to the level of the MDA-modified LDL in a control; the monoclonal antibody mAb-1H11 being produced by hybridoma Hyb1H11, which was deposited on Apr. 24, 1997 at the Belgian Coordinated Collections Of Microorganisms under accession number LMBP 1659 CB\n
(d) performing an assay for a heart protein that is a marker for acute myocardial infarction on one of the one or more human samples and comparing a level of a heart protein in the human sample from the assay to the level of the heart protein in a control; and\n
(e) making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b), (c), and (d) are all performed:\n\n1.4 Indication(b)(c)(d)the individual does not have coronary artery disease−−−the individual has chronic coronary artery disease+−−the individual has unstable angina++−the individual has acute myocardial infarction of+++atherosclerotic originthe individual has acute myocardial infarction of−−+non-atherosclerotic origin\nor making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (b) and (c) are performed:\n1.5 Indication(b)(c)the individual does not have coronary artery disease−−the individual has chronic coronary artery disease+−the individual has acute coronary artery disease++\nor making a diagnosis based on results from step (c) and at least one of steps (b) and (d) from the following matrix if steps (c) and (d) are performed:\n1.6 Indication(c)(d)the individual does not have acute coronary artery disease−−the individual has unstable angina+−the individual has acute myocardial infarction of−+non-atherosclerotic originthe individual has acute myocardial infarction of++atherosclerotic origin\n
wherein “+” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control and “−” indicates that the level of the OxLDL, MDA-modified LDL, and heart protein in the human sample is not higher compared to the level of the OxLDL, MDA-modified LDL, and heart protein in the control, the control providing results based on those of a normal control population."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein steps (a), (b), (c), and (e) are performed."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein steps (a), (c), (d), and (e) are performed."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein steps (a), (b), (c), (d), and (e) are performed."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein at least one human sample is plasma."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein at least one human sample is serum."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11 wherein the level in the control for each of OxLDL, MDA-modified LDL, and heart protein is representative of the level in a sampling of individuals of a general population who have no history of atherosclerotic cardiovascular disease."],"number":17,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}