{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"110-989-974-155-314","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"110-989-974-155-314","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10809,"type":"PATENT","title":"Leiden University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2497,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8272,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Leiden Univ*\"
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This extensive patent family relates to Crucell’s adenoviral based materials and packaging cell lines, including the PER.C6™ packaging cell line and systems for producing replication incompetent adenovirus.
","published":true,"created":"2010-12-07T00:22:50Z","updated":"2010-12-07T00:22:50Z","sharedType":"PUBLISHED","lensId":"054-936-138-394-370","scope":"FAMILYINFO"}],"inventorships":[],"privateCollections":[],"publicCollections":[{"id":10809,"type":"PATENT","title":"Leiden University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2497,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8272,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"Search Applicants and Owners separately: \"Leiden Univ*\"
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a nucleic acid encoding pIX gene product;\n
an expression cassette encoding a nonadenovirus gene product;\n
an adenoviral encapsidation signal; and\n
a 5′ adenoviral ITR or a derivative thereof and a 3′ adenoviral ITR or a derivative thereof;\n
wherein the recombinant adenovirus genome does not contain sequences of adenovirus E1A, E1B 21 kDa and E1B 55 kDa coding regions; and\n
wherein said stock of the recombinant adenoviruses is free of replication-competent adenovirus."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 1, wherein the deletion in the at least part of the E1 region comprises a deletion of nucleotides corresponding nt. 459 to nt. 3510 of the adenovirus 5 genome."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 1, wherein said recombinant adenovirus is capable of replication in a packaging cell line."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 3, wherein said packaging cell line comprises a cell line deposited at the European Collection of Animal Cell Cultures under No. 96022940."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 1, wherein the genome of said recombinant adenovirus further comprises other adenovirus sequences capable of allowing replication of said recombinant adenovirus in an E1-complementing cell."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 2, wherein the genome of said recombinant adenovirus further comprises other adenovirus sequences capable of allowing replication of said recombinant adenovirus in an E1-complementing cell."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The stock of claim 4, wherein the stock of recombinant adenoviruses is capable of being produced in the packaging cell line on a large scale."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["A stock of recombinant adenoviruses, each recombinant adenovirus thereof having a genome, the genome comprising:\n
a nucleic acid encoding pIX gene product;\n
an expression cassette encoding a nonadenovirus gene product;\n
an adenoviral encapsidation signal; and\n
a 5′ adenoviral ITR or a derivative thereof and a 3′ adenoviral ITR or a derivative thereof;\n
wherein the genome does not contain sequences of adenovirus E1A, E1B 21 kDa and E1B 55 kDa coding regions and further has a deletion of one or more of adenovirus E2A and adenovirus E3; and\n
wherein said stock is free of replication-competent adenovirus."],"number":8,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}