{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"109-511-732-208-104","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"109-511-732-208-104","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10731,"type":"PATENT","title":"The University of North Carolina at Chapel Hill - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":8887,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8232,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
Search Applicants and Owners separately:\"uni* north caro*\". Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1000
(a) a cDNA comprising SEQ ID NO:1;\n
(b) a cDNA comprising the nucleotide sequence that encodes the DOT1L polypeptide of SEQ ID NO:2;\n
(c) a cDNA that differs from the nucleotide sequence of (a) due to the degeneracy of the genetic code;\n
(d) a cDNA consisting of a fragment of SEQ ID NO:1, wherein said fragment consists of a nucleotide sequence that encodes amino acids 1 to 416 of SEQ ID NO:2;\n
(e) a cDNA consisting of a nucleotide sequence that has at least 95% sequence similarity to the cDNA of (d), wherein said cDNA encodes a polypeptide having H3-K79 methyltransferase activity; and\n
(f) a cDNA consisting of a nucleotide sequence that differs from the nucleotide sequence of (d) due to the degeneracy of the genetic code, wherein said cDNA encodes a polypeptide having H3-K79 methyltransferase activity."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The isolated cDNA of claim 1, wherein the cDNA encodes the DOT1L polypeptide of SEQ ID NO:2."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The isolated cDNA of claim 1, wherein the cDNA comprises SEQ ID NO:1."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The isolated cDNA of claim 1, wherein the cDNA consists of SEQ ID NO:1."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The isolated cDNA of claim 1, wherein the cDNA encodes a DOT1L fusion protein."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A vector comprising the isolated cDNA of claim 1."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The vector of claim 6, wherein the vector is an expression vector."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["An isolated cell comprising the isolated cDNA of claim 1."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["An isolated cell comprising the vector of claim 6."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A method of producing a DOT1L polypeptide, comprising culturing the cell of claim 8 in vitro such that the DOT1L polypeptide is expressed from said cDNA encoding the DOT1L polypeptide."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["An expression vector comprising a cDNA encoding a DOT1L polypeptide having histone H3 lysine 79 (H3-K79) methyltransferase activity, wherein the cDNA (a) consists of SEQ ID NO:1; or (b) consists of a nucleotide sequence that has at least 97% nucleotide sequence similarity with SEQ ID NO:1, wherein said cDNA encodes a polypeptide having H3-K79 methyltransferase activity."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["An isolated cell comprising the expression vector of claim 11."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A method of producing a DOT1L polypeptide, comprising culturing the cell of claim 12 in vitro such that the DOT1L polypeptide is expressed from said cDNA encoding the DOT1L polypeptide."],"number":13,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}