{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"108-643-503-175-319","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"108-643-503-175-319","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11910,"type":"PATENT","title":"Drexel University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2073,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8498,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
wherein\n
R1 is hydrogen;\n
R2 is selected from a group consisting of hydrogen, methyl, trifluoromethyl, fluorine, and chlorine;\n
R3 is selected from a group consisting of hydrogen, methyl, fluorine, and chlorine;\n
R4 is selected from a group consisting of hydrogen, fluorine, chlorine, and methyl;\n
R5 is selected from a group consisting of hydrogen and chlorine;\n
R7 is selected from a group consisting of hydrogen, chlorine, fluorine, and bromine;\n
R9 is selected from a group consisting of hydrogen, methyl, fluorine, and chlorine;\n
Rx is selected from the group consisting of: NH2,\n\n\n
or a pharmaceutically acceptable salt form thereof."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the at least one compound is selected from the group consisting of\n
2-Chloro-5-sulfamoyl-N-3-methylphenyl-benzamide;\n
4-Fluoro-3-sulfamoyl-N-(3-trifluoromethyl-phenyl)-benzamide;\n
N-(2-Chloro-5-trifluoromethyl-phenyl)-4-fluoro-3-sulfamoyl-benzamide;\n
N-Phenyl-3-sulfamoyl-benzamide;\n
5-sec-Butylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
3-Diethylsulfamoyl-N-phenyl-benzamide;\n
5-Diethylsulfarnoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzarnide;\n
2-Chloro-5-diethylsulfamoyl-N-m-tolyl-benzamide;\n
N-(4-Chloro-phenyl)-3-diethylsulfamoyl-benzamide;\n
5-Allylsulfamoyl-N(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-5-dipropylsulfamoyl-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-2-fluoro-N-p-tolyl-benzamide;\n
5-Cyclohexylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
2-Bromo-5-cyclohexylsulfamoyl-N-phenyl-benzamide;\n
4-Chloro-3-cyclohexylsulfamoyl-N-(4-fluoro-phenyl)-benzamide;\n
3-Cyclohexylsulfamoyl-4-methyl-N-phenyl-benzamide;\n
N-(3,4-Difluoro-phenyl)-4-fluoro-3-(2-methyl-cyclohexylsulfamoyl)-benzamide;\n
3-Cyclopentylsulfamoyl-N-phenyl-benzamide,\n
5-Cyclopentylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclopentylsulfamoyl-2-fluoro-N-(4-fluoro-phenyl)-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
3-Cyclopentylsulfamoyl-4-fluoro-N-3-methylphenyl-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,5-dichloro-phenyl)-2-fluoro-benzamide;\n
3-[(Furan-2-ylmethyl)-sulfamoyl]-N-phenyl-benzamide;\n
N-(3-Chloro-4-fluoro-phenyl)-5-[(furan-2-ylmethyl)-sulfamoyl]-2-methyl-benzamide;\n
2-Fluoro-N-(3-fluoro-phenyl)-5-[(furan-2-ylmethyl)-sulfamoyl]-benzamide;\n
N-(3,5-Dichloro-phenyl)-2-fluoro-5-[(furan-2-ylmethyl)-sulfamoyl]-benzamide;\n
4-Fluoro-3-[(furan-2-ylmethyl)-sulfamoyl]-N-3-methylphenyl-benzamide;\n
5-[(4-Chloro-3-phenylcarbamoyl-benzenesulfonylamino)-methyl]-furan-2-carboxylic acid methyl ester;\n
N-(3-Chloro-phenyl)-5-(2-cyclohex-1-enyl-ethylsulfamoyl)-2-fluoro-benzamide;\n
5-(2-Cyclohex-1-enyl-ethylsulfamoyl)-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
5-(2-Cyclohex-1-enyl-ethylsulfamoyl)-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
N-(3-Chloro-phenyl)-4-fluoro-3-[(pyridin-3-ylmethyl)-sulfamoyl]-benzamide;\n
N-(3,4-Difluoro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
N-(3-Chloro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
5-Benzylsulfamoyl-N-(3-chloro-4-fluoro-phenyl)-2-fluoro-benzamide;\n
5-Benzylsulfamoyl-2-chloro-N-phenyl-benzamide;\n
N-(4-Chloro-phenyl)-5-[2-(3,4-dimethoxy-phenyl)-ethylsulfamoyl]-2-fluoro-benzamide;\n
5-(2-Chloro-benzylsulfamoyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
3-(2-Chloro-benzylsulfamoyl)-N-(4-chloro-phenyl)-4-fluoro-benzamide;\n
2-Fluoro-5-(4-methoxy-phenylsulfamoyl)-N-3-methylphenyl-benzamide;\n
2-Fluoro-5-(4-fluoro-phenylsulfamoyl)-N-3-methylphenyl-benzamide;\n
N-(4-Chloro-phenyl)-3-(3-fluoro-phenylsulfamoyl)-benzamide;\n
N-(4-Chloro-phenyl)-3-2-methylphenylsulfamoyl-benzamide;\n
N-Phenyl-3-m-tolylsulfamoyl-benzamide;\n
N-Phenyl-3-o-tolylsulfamoyl-benzamide;\n
3-(Benzyl-ethyl-sulfamoyl)-N-(3,4-difluoro-phenyl)-4-fluoro-benzamide;\n
5-(Azepane-1-sulfonyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
4-Methyl-N-phenyl-3-(piperidine-1-sulfonyl)-benzamide;\n
4-chloro-N-(4-fluorophenyl)-3-(piperidin-1-ylsulfonyl)benzamide;\n
4-Chloro-N-(3-fluoro-phenyl)-3-(morpholine-4-sulfonyl)-benzamide;\n
4-Chloro-N-phenyl-3-(thiomorpholine-4-sulfonyl)-benzamide;\n
or a pharmaceutically acceptable form thereof."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the at least one compound is administered in a composition further comprising at least one pharmaceutically acceptable excipient."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the at least one compound is selected from the group consisting of\n
2-Chloro-5-sulfamoyl-N-3-methylphenyl-benzamide;\n
4-Fluoro-3-sulfamoyl-N-(3-trifluoromethyl-phenyl)-benzamide;\n
N-(2-Chloro-5-trifluoromethyl-phenyl)-4-fluoro-3-sulfamoyl-benzamide;\n
N-Phenyl-3-sulfamoyl-benzamide;\n
5-sec-Butylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
3-Diethylsulfamoyl-N-phenyl-benzamide;\n
5-Diethylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzarnide;\n
2-Chloro-5-diethylsulfamoyl-N-m-tolyl-benzamide;\n
N-(4-Chloro-phenyl)-3-diethylsulfamoyl-benzamide;\n
5-Allylsulfamoyl-N(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-5-dipropylsulfamoyl-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-2-fluoro-N-p-tolyl-benzamide;\n
5-Cyclohexylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
2-Bromo-5-cyclohexylsulfamoyl-N-phenyl-benzamide;\n
4-Chloro-3-cyclohexylsulfamoyl-N-(4-fluoro-phenyl)-benzamide;\n
3-Cyclohexylsulfamoyl-4-methyl-N-phenyl-benzamide;\n
N-(3,4-Difluoro-phenyl)-4-fluoro-3-(2-methyl-cyclohexylsulfamoyl)-benzamide;\n
3-Cyclopentylsulfamoyl-N-phenyl-benzamide,\n
5-Cyclopentylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclopentylsulfamoyl-2-fluoro-N-(4-fluoro-phenyl)-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
3-Cyclopentylsulfamoyl-4-fluoro-N-3-methylphenyl-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,5-dichloro-phenyl)-2-fluoro-benzamide;\n
3-[(Furan-2-ylmethyl)-sulfamoyl]-N-phenyl-benzamide;\n
N-(3-Chloro-4-fluoro-phenyl)-5-[(furan-2-ylmethyl)-sulfamoyl]-2-methyl-benzamide;\n
2-Fluoro-N-(3-fluoro-phenyl)-5-[(furan-2-ylmethyl)-sulfamoyl]-benzamide;\n
N-(3,5-Dichloro-phenyl)-2-fluoro-5-[(furan-2-ylmethyl)-sulfamoyl]-benzamide;\n
4-Fluoro-3-[(furan-2-ylmethyl)-sulfamoyl]-N-3-methylphenyl-benzamide;\n
5-[(4-Chloro-3-phenylcarbamoyl-benzenesulfonylamino)-methyl]-furan-2-carboxylic acid methyl ester;\n
N-(3-Chloro-phenyl)-5-(2-cyclohex-1-enyl-ethylsulfamoyl)-2-fluoro-benzamide;\n
5-(2-Cyclohex-1-enyl-ethylsulfamoyl)-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
5-(2-Cyclohex-1-enyl-ethylsulfamoyl)-N-(3,5-dimethyl-phenyl)-2-fluoro-benzamide;\n
N-(3-Chloro-phenyl)-4-fluoro-3-[(pyridin-3-ylmethyl)-sulfamoyl]-benzamide;\n
N-(3,4-Difluoro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
N-(3-Chloro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
5-Benzylsulfamoyl-N-(3-chloro-4-fluoro-phenyl)-2-fluoro-benzamide;\n
5-Benzylsulfamoyl-2-chloro-N-phenyl-benzamide;\n
N-(4-Chloro-phenyl)-5-[2-(3,4-dimethoxy-phenyl)-ethylsulfamoyl]-2-fluoro-benzamide;\n
5-(2-Chloro-benzylsulfamoyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
3-(2-Chloro-benzylsulfamoyl)-N-(4-chloro-phenyl)-4-fluoro-benzamide;\n
2-Fluoro-5-(4-methoxy-phenylsulfamoyl)-N-3-methylphenyl-benzamide;\n
2-Fluoro-5-(4-fluoro-phenylsulfamoyl)-N-3-methylphenyl-benzamide;\n
N-(4-Chloro-phenyl)-3-(3-fluoro-phenylsulfamoyl)-benzamide;\n
N-(4-Chloro-phenyl)-3-2-methylphenylsulfamoyl-benzamide;\n
N-Phenyl-3-m-tolylsulfamoyl-benzamide;\n
N-Phenyl-3-o-tolylsulfamoyl-benzamide;\n
3-(Benzyl-ethyl-sulfamoyl)-N-(3,4-difluoro-phenyl)-4-fluoro-benzamide;\n
5-(Azepane-1-sulfonyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
4-Methyl-N-phenyl-3-(piperidine-1-sulfonyl)-benzamide;\n
4-chloro-N-(4-fluorophenyl)-3-(piperidin-1-ylsulfonyl)benzamide;\n
4-Chloro-N-(3-fluoro-phenyl)-3-(morpholine-4-sulfonyl)-benzamide;\n
4-Chloro-N-phenyl-3-(thiomorpholine-4-sulfonyl)-benzamide;\n
or a pharmaceutically acceptable form thereof."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the compound having formula (I) is at least one compound having formula (II):\n
or a hydrate, solvate, pharmaceutically acceptable salt, pro-drug or complex thereof, wherein:\n
Rx is selected from the group consisting of:"],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the at least one compound is selected from the group consisting of\n
5-sec-Butylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Diethylsulfamoyl-N-(3,4-difluoro-pheriyl)-2-fluoro-benzamide;\n
5-Allylsulfamoyl-N(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-5-dipropylsulfamoyl-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-(Azepane-1-sulfonyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclohexylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
5-(2-Chloro-benzylsulfamoyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
or a pharmaceutically acceptable form thereof."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the at least one compound is administered in a composition further comprising at least one pharmaceutically acceptable excipient."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the at least one compound is selected from the group consisting of\n
5-sec-Butylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Diethylsulfamoyl-N-(34-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Diethylsulfamoyl-N-(3,4-difluoro-pheriyl)-2-fluoro-benzamide;\n
5-Allylsulfamoyl-N(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-5-dipropylsulfamoyl-2-fluoro-benzamide;\n
5-Cycloheptylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-(Azepane-1-sulfonyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclohexylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
5-Cyclopentylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
N-(3,4-Difluoro-phenyl)-2-fluoro-5-phenethylsulfamoyl-benzamide;\n
5-(2-Chloro-benzylsulfamoyl)-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide;\n
or a pharmaceutically acceptable form thereof."],"number":8,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}