{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"106-625-730-702-965","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"106-625-730-702-965"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11995,"type":"PATENT","title":"University of Duisburg-Essen Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":555,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8560,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Univ* Duisburg*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 555
Search Applicants and Owners separately:Univ* Duisburg*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 555
• \"Au\" denotes the Au0 atoms in said gold nanocluster compound;
• \"n\" is a whole number denoting the number of gold atoms in said gold nanocluster compound, preferably n being selected in the range of from 20 to 80, especially 25 to 70, preferably 30 to 60, even more preferably 35 to 55, the outer limits of these ranges being included, with n being most preferably 35 if m = 35 or 55 if m = 12;
• \"L\", identical or different, denotes the ligand(s) in said gold nanocluster compound, especially an organic ligand, preferably a ligand based on a triphenylphosphine or a triphenylphosphine derivative, especially a sulfonated triphenylphosphine, a sulfonate, a sulfate, a phosphate, a phosphonate, a carbonate, a carboxylate or mixtures thereof, more preferably a ligand based on a triphenylphosphine or a triphenylphosphine derivative, especially a sulfonated triphenylphosphine;
• \"m\" is a whole number denoting the number of ligands in said gold nanocluster compound, preferably m being selected in the range of from 5 to 50, especially 10 to 40, preferably 12 to 35, the outer limits of these ranges being included, with m being most preferably 12 if n = 55 or 35 if n = 35,wherein said gold nanocluster compound has been subjected to a stabilization treatment, wherein such stabilization treatment is performed:
• by treatment with at least one antioxidant, especially selected from the group consisting of N-acetylcysteine (NAC), glutathione (GSH), sulfonated triphenylphosphines, especially monosulfonated triphenylphosphines (TPPMS), and/or ascorbic acid as well as mixtures thereof; and/or
• by providing with a secondary ligand shell, especially wherein the secondary ligand surrounds and/or compasses said gold nanocluster compound including its core and its ligands and/or especially wherein the secondary ligand shell is provided to said gold nanocluster compound by an excess of said ligand; and/or
• by treatment with at least one sulfur-containing organic compound, especially selected from the group consisting of thiols, dithiols, disulfides, thioethers, thioesters and mixtures thereof, preferably N-acetylcysteine (NAC) and/or glutathione (GSH) or mixtures thereof, especially wherein the sulfur-containing organic compound binds via its sulfur atom(s) to the core of the gold nanocluster compound, preferable under formation of an Au-S-bonding."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A diagnostic composition, especially for the use in imaging procedures or techniques, especially in the field of human or veterinary medicine or in the field of material testing, preferably in the form of a liquid composition such as a solution or a dispersion, said diagnostic composition comprising at least one gold nanocluster compound as in any of Claims 1 to 12, preferably together with at least one essentially non-toxic carrier or excipient."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["Use of at least one gold nanocluster compound as defined in any of Claims 1 to 12 in the fields of medicine, especially human and veterinary medicine, medical technology and material sciences, especially in the testing of materials."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["Use of at least one gold nanocluster compound as defined in any of Claims 1 to 12 in the manufacture of a diagnostic composition, especially for use in imaging procedures or imaging techniques, particularly medical imaging such as X-ray imaging, computed tomography (CT) and photoacoustic imaging or imaging in material sciences such as testing of materials."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["Use of at least one gold nanocluster compound as defined in any of Claims 1 to 12 as a contrast agent or a contrast enhancer in imaging procedures or imaging techniques, particularly medical imaging such as X-ray imaging, computed tomography (CT) or photoacoustic imaging or imaging in material sciences such as testing of materials."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A process of controlling and/or reducing the toxicity, especially cytotoxicity, of a gold nanocluster compound or gold nanoparticle, especially a ligand-stabilized gold nanocluster compound or gold nanoparticle, preferably for use in medical diagnostics, wherein the control and/or reduction of toxicity, especially cytotoxicity, of said gold nanocluster compound or gold nanoparticle is controlled and/or adjusted via its ligand structure and/or ligand chemistry, especially wherein said gold nanocluster compound or gold nanoparticle is as defined in any of Claims 1 to 12."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The gold nanocluster compound, the use and/or the process, each as defined in any of the preceding claims, wherein gold is at least partially replaced by another transition metal, especially selected from the group consisting of platinum (Pt), rhodium (Rh), iridium (Ir), palladium (Pd), ruthenium (Ru), osmium (Os) and silver (Ag) or mixtures thereof."],"number":18,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}