{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"104-506-866-020-897","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"104-506-866-020-897"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8906,"type":"PATENT","title":"Univ Pennsylvania Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":24238,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8221,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search Applicants and Owners separately: Arizona AND State AND Univ*;
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search Applicants and Owners separately: Univ* AND Arizona;
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Search Applicants and Owners separately: Arizona AND State AND Univ*;
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(a) a mutation selected from the group consisting of a ΔPhilA::PtrcΔlacO hilA mutation and a ΔPhilA::PhilA hilA mutation, wherein the ΔPhilA::PhilA hilA mutation comprises a mutation in the hilA promoter that reduces nucleoid-associated protein H-NS binding,\n
(b) a ΔtlpA mutation and a ΔsseL mutation and, optionally at least one mutation selected from the group consisting of an ampG mutation, an ampD mutation, and a nagE mutation, and\n
(c) at least one mutation selected from the group consisting of a tlyC mutation, a pld mutation, a ΔsifA mutation and a ΔPsifA::TT araC PBAD sifA mutation."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 1, wherein the bacterium lacks expression of sifA."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant Salmonella bacterium, wherein the bacterium is:\n
(a) capable of regulated delayed attenuation,\n
(b) capable of regulated delayed lysis, characterized by a ΔPmurA::TT araC PBAD murA mutation and a ΔasdA::TT araC PBAD c2 mutation,\n
(c) capable of escape from a host endosomal compartment, characterized by at least one mutation selected from the group consisting of a tlyC mutation and a pld mutation,\n
(d) capable of hyper-invasion, characterized by hilA operably linked to a constitutive promoter, and\n
(e) capable of reducing bacterium-induced host programmed cell death, characterized by a ΔtlpA mutation and a ΔsseL mutation and, optionally, at least one mutation selected from the group consisting of an ampG mutation, an ampD mutation, and a nagE mutation."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the programmed cell death is pyroptosis or apoptosis."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the bacterium further comprises a DNA vaccine encoding a protective antigen."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 5, wherein the DNA vaccine comprises a nucleic acid sequence encoding one or more bacterial, viral, protozoan, or fungal antigens."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 5, wherein the DNA vaccine comprises a nucleic acid sequence encoding one or more influenza antigens."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the bacterium further comprises a single vector for the production of influenza virus."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the bacterium escapes from the host endosomal compartment before undergoing regulated lysis."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 5, wherein the DNA vaccine comprises a repeated DNA nuclear targeting sequence and a nuclease resistant polyadenylation encoding sequence."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 10, wherein the DNA vaccine comprises an artificial NF-kB recognition sequence and or an artificial AP-2 recognition sequence."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 5, wherein the DNA vaccine comprises the vector pYA4545."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 5, wherein the DNA vaccine comprises an influenza HA antigen-SopE C-terminal fusion."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the bacterium further comprises the vector pYA3681."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 1, wherein the bacterium comprises a ΔampG mutation, a ΔampD mutation, or a ΔnagE mutation."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 10, wherein the nuclease resistant polyadenylation sequence is derived from a DNA virus capable of replicating in a eukaryote."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant Salmonella bacterium, wherein the bacterium is:\n
(a) capable of regulated delayed attenuation,\n
(b) capable of regulated delayed lysis, characterized by ΔPmurA::TT araC PBAD murA mutation and a ΔasdA::TT araC PBAD c2 mutation,\n
(c) capable of escape from a host endosomal compartment, characterized by at least one mutation selected from the group consisting of a tlyC mutation, a pld mutation, a ΔsifA mutation and ΔPsifA::TT araC PBAD sifA mutation,\n
(d) capable of hyper-invasion, characterized by hilA operably linked to a constitutive promoter, and\n
(e) capable of reducing bacterium-induced host programmed cell death, characterized by a ΔtlpA mutation and a ΔsseL mutation and, optionally, a mutation selected from the group consisting of an ampG mutation, an ampD mutation, and a nagE mutation."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 3, wherein the hilA operably linked to a constitutive promoter is selected from the group consisting of ΔPhilA::PtrcΔlacO hilA and ΔPhilA::PhilA hilA mutation, wherein the ΔPhilA::PhilA hilA mutation comprises a mutation in the hilA promoter that reduces nucleoid-associated protein H-NS binding."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The recombinant Salmonella bacterium of claim 17, wherein the hilA operably linked to a constitutive promoter is selected from the group consisting of a ΔPhilA::PtrcΔlacO hilA mutation and a ΔPhilA::PhilA hilA mutation, wherein the ΔPhilA::PhilA hilA mutation comprises a mutation in the hilA promoter that reduces nucleoid-associated protein H-NS binding."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["A recombinant Salmonella bacterium, wherein the bacterium is:\n
(a) capable of regulated delayed attenuation,\n
(b) capable of regulated delayed lysis, characterized by a ΔPmurA::TT araC PBAD murA mutation and a ΔasdA::TT araC PBAD c2 mutation,\n
(c) capable of escape from a host endosomal compartment, characterized by at least one mutation selected from the group consisting of a tlyC mutation, a pld mutation, a ΔsifA mutation and ΔPsifA::TT araC PBAD sifA mutation, and\n
(d) capable of reducing bacterium-induced host programmed cell death, characterized by a ΔtlpA mutation and a ΔsseL mutation and, optionally, a mutation selected from the group consisting of an ampG mutation, an ampG mutation, and a nagE mutation."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["A vaccine, the vaccine comprising the recombinant Salmonella bacterium of claim 20."],"number":21,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}