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for invention","granted":true,"earliest_filing_date":"2010-04-02","grant_date":"2014-07-22","anticipated_term_date":"2030-04-02","has_disclaimer":false,"patent_status":"ACTIVE","publication_count":2,"has_spc":false,"has_grant_event":true,"has_entry_into_national_phase":false},"abstract":{"en":[{"text":"Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"}]},"abstract_lang":["en"],"has_abstract":true,"claim":{"en":[{"text":"1. A composition comprising a crystalline form of L-ornithine phenyl acetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"2. The composition of claim 1 , wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising characteristic peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"3. The composition of claim 1 , wherein said crystalline form comprises water and/or ethanol molecules.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"4. The composition of claim 3 , wherein said crystalline form comprises about 11% by weight of said molecules as determined by thermogravimetric analysis.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"5. The composition of claim 1 , wherein said crystalline form is characterized by differential scanning calorimetry as comprising an endotherm at about 35° C.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"6. The composition of claim 5 , further comprising a melting point at about 203° C.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"7. The composition of claim 1 , wherein said crystalline form exhibits a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following: unit cell dimensions: a=5.3652(4) Å, b=7.7136(6) Å, c=20.9602(18) Å, α=90°, β=94.986(6)°, γ=90°; Crystal System: Monoclinic; and Space Group: P2 1 .","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"8. The composition of claim 1 , wherein the said crystalline form is represented by the formula [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]EtOH.H 2 O.","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"},{"text":"9. A method of treating or ameliorating hyperammonemia in a subject by orally administering a therapeutically effective amount of the crystalline form of claim 2 .","lang":"en","source":"USPTO_FULLTEXT","data_format":"ORIGINAL"}]},"claim_lang":["en"],"has_claim":true,"description":{"en":{"text":"INCORPORATION BY REFERENCE TO ANY PRIORITY APPLICATIONS This application is a divisional of U.S. application Ser. No. 13/436,642, filed Mar. 30, 2013; which is a divisional of U.S. application Ser. No. 12/753,763, filed Apr. 2, 2010, issued as U.S. Pat. No. 8,173,706; which claims the benefit of priority of U.S. Provisional Application No. 61/166,676, filed Apr. 3, 2009. The priority documents are hereby incorporated by reference in their entireties. This application relates to PCT/US10/29708, filed Apr. 1, 2010, which was published in English as WO 2010/115055 A1 and designates the United States, and is hereby incorporated by reference in its entirety. Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. BACKGROUND 1. Field The present application relates to the fields of pharmaceutical chemistry, biochemistry, and medicine. In particular, it relates to L-ornithine phenyl acetate salts and methods of making and using the same. 2. Description Hyperammonemia is a hallmark of liver disease and is characterized by an excess of ammonia in the bloodstream. Hepatic encephalopathy is a primary clinical consequence of progressive hyperammonemia and is a complex neuropsychiatric syndrome, which may complicate acute or chronic hepatic failure. It is characterized by changes in mental state including a wide range of neuropsychiatric symptoms ranging from minor signs of altered brain function to overt psychiatric and/or neurological symptoms, or even deep coma. The accumulation of unmetabolized ammonia has been considered as the main factor involved in the pathogenesis of hepatic encephalopathy, but additional mechanisms may be associated. L-Ornithine monohydrochloride and other L-ornithine salts are available for their use in the treatment of hyperammonemia and hepatic encephalopathy. For example, U.S. Publication No. 2008/0119554, which is hereby incorporated by reference in its entirety, describes compositions of L-ornithine and phenyl acetate for the treatment of hepatic encephalopathy. L-ornithine has been prepared by enzymatic conversion methods. For example, U.S. Pat. Nos. 5,405,761 and 5,591,613, both of which are hereby incorporated by reference in their entirety, describe enzymatic conversion of arginine to form L-ornithine salts. Sodium phenyl acetate is commercially available, and also available as an injectable solution for the treatment of acute hyperammonemia. The injectable solution is marketed as AMMONUL. Although salt forms may exhibit improved degradation properties, certain salts, particularly sodium or chloride salts, may be undesirable when treating patients having diseases associated with the liver disease, such as hepatic encephalopathy. For example, a high sodium intake may be dangerous for cirrhotic patients prone to ascites, fluid overload and electrolyte imbalances. Similarly, certain salts are difficult to administer intravenously because of an increased osmotic pressure, i.e., the solution is hypertonic. High concentrations of excess salt may require diluting large volumes of solution for intravenous administration which, in turn, leads to excessive fluid overload. Accordingly, there exists a need for the preparation of L-ornithine and phenyl acetate salts which are favorable for the treatment of hepatic encephalopathy or other conditions where fluid overload and electrolyte imbalance are prevalent. SUMMARY Some embodiments disclosed herein include a composition comprising a crystalline form of L-ornithine phenyl acetate. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising characteristic peaks at approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ. In some embodiments, the crystalline form has a melting point of about 202° C. In some embodiments, the crystalline form exhibits a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following: unit cell dimensions: a=6.594(2) Å, b=6.5448(18) Å, c=31.632(8) Å, α=90°, β=91.12(3)°, γ=90°; Crystal System: Monoclinic; and Space Group: P2 1 . In some embodiments, the crystalline form is represented by the formula [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]. Some embodiments have the crystalline form exhibit an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising characteristic peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ. Some embodiments have the crystalline form comprising water and/or ethanol molecules. In some embodiments, the crystalline form comprises about 11% by weight of said molecules as determined by thermogravimetric analysis. In some embodiments, the crystalline form is characterized by differential scanning calorimetry as comprising an endotherm at about 35° C. In some embodiments, the crystalline has a melting point at about 203° C. Some embodiments have the crystalline form exhibiting a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following: unit cell dimensions: a=5.3652(4) Å, b=7.7136(6) Å, c=20.9602(18) Å, α=90°, β=94.986(6)°, γ=90′; Crystal System: Monoclinic; and Space Group: P2 1 . In some embodiments, the crystalline form is represented by the formula [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]EtOH.H 2 O. Some embodiments have the crystalline form exhibiting an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising characteristic peaks at approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ. In some embodiments, the crystalline form is characterized by differential scanning calorimetry as comprising an endotherm at about 40° C. In some embodiments, the crystalline form comprises a melting point at about 203° C. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peak is selected from the group consisting of approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. In some embodiments, the crystalline form exhibits an X-ray powder diffraction pattern comprising characteristic peaks at approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. In some embodiments, the crystalline form is characterized by differential scanning calorimetry as comprising an endotherm at about 174° C. In some embodiments, the crystalline form has a melting point of about 196° C. In some embodiments, the crystalline form comprises a pharmaceutically acceptable carrier. Some embodiments disclosed herein have a composition comprising: at least about 50% by weight of a crystalline form of L-ornithine phenyl acetate salt and at least about 0.01% by weight benzoic acid or a salt thereof. In some embodiments, the composition comprises at least about 0.10% by weight benzoic acid or a salt thereof. In some embodiments, the composition comprises no more than 5% by weight benzoic acid or a salt thereof. In some embodiments, the composition comprises no more than 1% by weight benzoic acid or a salt thereof. In some embodiments, the composition further comprises at least 10 ppm silver. In some embodiments, comprises at least 20 ppm silver. In some embodiments, the composition further comprises at least 25 ppm silver. In some embodiments, comprises no more than 600 ppm silver. In some embodiments, composition comprises no more than 100 ppm silver. In some embodiments, the composition comprises no more than 65 ppm silver. In some embodiments, about 50 mg/mL of the composition in water is isotonic with body fluids. In some embodiments, the isotonic solution has an osmolality in the range of about 280 to about 330 mOsm/kg. In some embodiments, the composition has a density in the range of about 1.1 to about 1.3 kg/m 3 . Some embodiments disclosed herein include a process for making L-ornithine phenyl acetate salt comprising: intermixing an L-ornithine salt, a benzoate salt and a solvent to form an intermediate solution; intermixing phenyl acetate with said intermediate solution; and isolating a composition comprising at least 70% crystalline L-ornithine phenyl acetate by weight. In some embodiments, the process comprises removing at least a portion of a salt from said intermediate solution before intermixing the phenyl acetate, wherein said salt is not an L-ornithine salt. In some embodiments, the process comprises adding hydrochloric acid before removing at least a portion of the salt. In some embodiments, intermixing the L-ornithine, the benzoate salt and the solvent comprises: dispersing the L-ornithine salt in water to form a first solution; dispersing the benzoate salt in DMSO to form a second solution; and intermixing said first solution and said second solution to form said solution. In some embodiments, the composition comprises at least about 0.10% by weight benzoate salt. In some embodiments, composition comprises no more than 5% by weight benzoate salt. In some embodiments, composition comprises no more than 1% by weight benzoate salt. In some embodiments, the L-ornithine salt is L-ornithine hydrochloride. In some embodiments, the benzoate salt is silver benzoate. In some embodiments, the composition comprises at least 10 ppm silver. In some embodiments, composition comprises at least 20 ppm silver. In some embodiments, the composition comprises at least 25 ppm silver. In some embodiments, the composition comprises no more than 600 ppm silver. In some embodiments, the composition comprises no more than 100 ppm silver. In some embodiments, the composition comprises no more than 65 ppm silver. In some embodiments, the phenyl acetate is in an alkali metal salt. In some embodiments, the alkali metal salt is sodium phenyl acetate. In some embodiments, the composition comprises no more than 100 ppm sodium. In some embodiments, the composition comprises no more than 20 ppm sodium. In some embodiments, the L-ornithine is in a halide salt. In some embodiments, the halide salt is L-ornithine hydrochloride. In some embodiments, the composition comprises no more than 0.1% by weight chloride. In some embodiments, the composition comprises no more than 0.01% by weight chloride. Some embodiments disclosed herein include a composition obtained by any of the processes disclosed herein. Some embodiments disclosed herein include a process for making L-ornithine phenyl acetate salt comprising: increasing the pH value of a solution comprising an L-ornithine salt at least until an intermediate salt precipitates, wherein said intermediate salt is not an L-ornithine salt; isolating the intermediate salt from said solution; intermixing phenyl acetic acid with said solution; and isolating L-ornithine phenyl acetate salt from said solution. In some embodiments, the pH value is increased to at least 8.0. In some embodiments, the pH value is increased to at least 9.0. In some embodiments, increasing the pH value comprises adding a pH modifier selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium methoxide, potassium t-butoxide, sodium carbonate, calcium carbonate, dibutylamine, tryptamine, sodium hydride, calcium hydride, butyllithium, ethylmagnesium bromide or combinations thereof. Some embodiments disclosed herein include a method of treating or ameliorating hyperammonemia in a subject by administering a therapeutically effective amount of a crystalline form of L-ornithine phenyl acetate salt. In some embodiments, the crystalline form is administered orally. In some embodiments, the crystalline form is selected from the group consisting of Form I, Form II, Form III, Form V, wherein: Form I exhibits an X-ray powder diffraction pattern having characteristic peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ; Form II exhibits an X-ray powder diffraction pattern having characteristic peaks at approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ; Form III exhibits an X-ray powder diffraction pattern having characteristic peaks at approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ; and Form V exhibits an X-ray powder diffraction pattern having characteristic peaks at approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. In some embodiments, the crystalline form is Form I. In some embodiments, the crystalline form is Form II. In some embodiments, the crystalline form is Form III. In some embodiments, the crystalline form is Form V. In some embodiments, the at least two crystalline forms selected from the group consisting of Form I, Form II, Form III and Form V, are administered. In some embodiments, the at least two crystalline forms are administered at about the same time. In some embodiments, the crystalline form is administered from 1 to 3 times daily. In some embodiments, the therapeutically effective amount is in the range of about 500 mg to about 50 g. In some embodiments, the subject is identified as having hepatic encephalopathy. In some embodiments, the subject is identified as having hyperammonemia. Some embodiments disclosed herein include a process for making L-ornithine phenyl acetate salt comprising: intermixing an L-ornithine salt, silver phenyl acetate and a solvent to form a solution, wherein the L-ornithine salt is in halide salt; and isolating L-ornithine phenyl acetate from said solution. Some embodiments disclosed herein include a method of treating or ameliorating hyperammonemia comprising intravenously administering a therapeutically effective amount of a solution comprising L-ornithine phenyl acetate, wherein said therapeutically effective amount comprises no more than 500 mL of said solution. In some embodiments, the solution comprises at least about 25 mg/mL of L-ornithine phenyl acetate. In some embodiments, the solution comprises at least about 40 mg/mL of L-ornithine phenyl acetate. In some embodiments, the solution comprises no more than 300 mg/mL. In some embodiments, the solution is isotonic with body fluid. Some embodiments disclosed herein include a method of compressing L-ornithine phenyl acetate, the method comprising applying pressure to a metastable form of L-ornithine phenyl acetate to induce a phase change. In some embodiments, the metastable form is amorphous. In some embodiments, the metastable form exhibits an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 4.9°, 13.2°, 20.8° and 24.4° 2θ. In some embodiments, the pressure is applied for a predetermined time. In some embodiments, the predetermined time is about 1 second or less. In some embodiments, the pressure is at least about 500 psi. In some embodiments, the phase change yields a composition having a density in the range of about 1.1 to about 1.3 kg/m 3 after applying the pressure. In some embodiments, the phase change yields a composition exhibiting an X-ray powder diffraction pattern comprising at least one characteristic peak, wherein said characteristic peak is selected from the group consisting of approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ. Some embodiments disclosed herein include a composition obtained by applying pressure to a metastable form of L-ornithine phenyl acetate to induce a phase change. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an X-ray powder diffraction pattern of Form I. FIG. 2 shows differential scanning calorimetry results for Form I. FIG. 3 shows thermogravimetric gravimetric/differential thermal analysis of Form I. FIG. 4 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of Form I. FIG. 5 shows dynamic vapor sorption results for Form I. FIG. 6 is an X-ray powder diffraction pattern of Form II. FIG. 7 shows differential scanning calorimetry results for Form II. FIG. 8 shows thermogravimetric gravimetric/differential thermal analysis of Form II. FIG. 9 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of Form II. FIG. 10 shows dynamic vapor sorption results for Form II. FIG. 11 is an X-ray powder diffraction pattern of Form III. FIG. 12 shows differential scanning calorimetry results for Form III. FIG. 13 shows thermogravimetric gravimetric/differential thermal analysis of Form III. FIG. 14 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of Form III. FIG. 15 shows dynamic vapor sorption results for Form III. FIG. 16 is an X-ray powder diffraction pattern of Form V. FIG. 17 shows differential scanning calorimetry results for Form V. FIG. 18 shows thermogravimetric gravimetric/differential thermal analysis of Form V. FIG. 19 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of Form V. FIG. 20 shows dynamic vapor sorption results for Form V. FIG. 21 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of L-ornithine benzoate. FIG. 22 shows the 1 H nuclear magnetic resonance spectrum obtained from a sample of L-ornithine phenyl acetate. DETAILED DESCRIPTION Disclosed herein are methods of making L-ornithine phenyl acetate salts, and in particular, crystalline forms of said salt. These methods permit large-scale production of pharmaceutically acceptable forms of L-ornithine phenyl acetate using economical processes. Moreover, crystalline forms of L-ornithine phenyl acetate, including Forms I, II, III and V are also disclosed. The L-ornithine phenyl acetate salts permit intravenous administration with negligible concomitant sodium load, and therefore minimize the amount of i.v. fluid that is required. The present application relates to new crystalline forms of L-ornithine phenyl acetate salts, as well as methods of making and using L-ornithine phenyl acetate salts. The salt advantageously exhibits long-term stability without significant amounts of sodium or chloride. As a result, L-ornithine phenyl acetate is expected to provide an improved safety profile compared to other salts of L-ornithine and phenyl acetate. Also, L-ornithine phenyl acetate exhibits lower tonicity compared to other salts, and therefore can be administered intravenously at higher concentrations. Accordingly, L-ornithine phenyl acetate is expected to provide significant clinical improvements for the treatment of hepatic encephalopathy. The present application also relates to various polymorphs of L-ornithine phenyl acetate. The occurrence of different crystal forms (polymorphism) is a property of some molecules and molecular complexes. Salt complexes, such as L-ornithine phenyl acetate, may give rise to a variety of solids having distinct physical properties like melting point, X-ray diffraction pattern, infrared absorption fingerprint and NMR spectrum. The differences in the physical properties of polymorphs result from the orientation and intermolecular interactions of adjacent molecules (complexes) in the bulk solid. Accordingly, polymorphs can be distinct solids sharing the same active pharmaceutical ingredient yet having distinct advantageous and/or disadvantageous physico-chemical properties compared to other forms in the polymorph family. Method of Making L-Ornithine Phenyl Acetate Salt Some embodiments disclosed herein include a method of making L-ornithine phenyl acetate salt. L-Ornithine phenyl acetate may be produced, for example, through an intermediate salt, such as L-ornithine benzoate. As shown in Scheme 1, an L-ornithine salt of Formula I can be reacted with a benzoate salt of Formula II to obtain the intermediate L-ornithine benzoate. Various salts of L-ornithine may be used in the compound of Formula I, and therefore X in Formula I can be any ion capable of forming a salt with L-ornithine other than benzoic acid or phenyl acetic acid. X can be a monoatomic anion, such as, but not limited to, a halide (e.g., fluoride, chloride, bromide, and iodide). X can also be a polyatomic anion, such as, but not limited to, acetate, aspartate, formate, oxalate, bicarbonate, carbonate, bitrate, sulfate, nitrate, isonicotinate, salicylate, citrate, tartrate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, glutamate, methanesulfonate, ethanesulfonate, benzensulfonate, p-toluenesulfonate, pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate), phosphate and the like. In some embodiments, X is a monovalent ion. In some embodiments, X is chloride. Similarly, the benzoate salt of Formula II is not particularly limited, and therefore Y in Formula II can be any appropriate ion capable of forming a salt with benzoic acid. In some embodiments, Y can be a monoatomic cation, such as an alkali metal ion (e.g., Li + , Na + , and K + ) and other monovalent ions (e.g., Ag + ). Y may also be a polyatomic cation, such as ammonium, L-arginine, diethylamine, choline, ethanolamine, 1H-imidazole, trolamine, and the like. In some embodiments, Y is an inorganic ion. In some embodiments, Y is silver. Many other possible salts of L-ornithine and benzoic acid may be used for the compounds of Formulae I and II, respectively, and can readily be prepared by those skilled in the art. See, for example, Bighley L. D., et al., “Salt forms of drugs and absorption,” In: Swarbrick J., Horlan J. C., eds. Encyclopedia of pharmaceutical technology, Vol. 12. New York: Marcel Dekker, Inc. pp. 452-499, which is hereby incorporated by reference in its entirety. The intermediate L-ornithine benzoate (i.e., Formula III) can be prepared by intermixing solutions including compounds of Formulae I and II. As an example, the compounds of Formulae I and II may be separately dissolved in water and dimethyl sulfoxide (DMSO), respectively. The two solutions may then be intermixed so that the L-ornithine and benzoic acid react to form the salt of Formula III. Alternatively, the two salt compounds can be directly dissolved into a single solution. In some embodiments, L-ornithine and benzoic acid are dissolved in separate solvents, and subsequently intermixed. In some embodiments, L-ornithine is dissolved in an aqueous solution, benzoic acid is dissolved in an organic solvent, and the L-ornithine and benzoic acid solutions are subsequently intermixed. Non-limiting examples of solvents which may be used when intermixing L-ornithine and benzoate salts include acetonitrile, dimethylsulfoxide (DMSO), cyclohexane, ethanol, acetone, acetic acid, 1-propanol, dimethylcarbonate, N-methyl-2-pyrrolidone (NMP), ethyl acetate (EtOAc), toluene, isopropyl alcohol (IPA), diisopropoyl ether, nitromethane, water, 1,4 dioxane, tdiethyl ether, ethylene glycol, methyl acetate (MeOAc), methanol, 2-butanol, cumene, ethyl formate, isobutyl acetate, 3-methyl-1-butanol, anisole, and combinations thereof. In some embodiments, the L-ornithine benzoate solution includes water. In some embodiments, the L-ornithine benzoate solution includes DMSO. Upon intermixing L-ornithine and benzoate salts, counterions X and Y may form a precipitate that can be removed from the intermixed solution using known methods, such as filtration, centrifugation, and the like. In some embodiments, X is chloride, Y is silver, and the reaction produces a precipitate having AgCl. Although Scheme 1 shows the compounds of Formulae I and II as salts, it is also within the scope of the present application to intermix the free base of L-ornithine and benzoic acid to form the intermediate of L-ornithine benzoate. Consequently, forming and isolating the precipitate is optional. The relative amount of L-ornithine and benzoate salts that are intermixed is not limited; however the molar ratio of L-ornithine to benzoic acid may optionally be in the range of about 10:90 and 90:10. In some embodiments, the molar ratio of L-ornithine benzoate can be in the range of about 30:70 and 30:70. In some embodiments, the molar ratio of L-ornithine to benzoate can be in the range of about 40:60 and 60:40. In some embodiments, the molar ratio of L-ornithine to benzoate is about 1:1. In embodiments where X and Y are both inorganic ions (e.g., X and Y are chloride and silver, respectively), additional amounts of X-containing salt may be added to encourage further precipitation of the counterion Y. For example, if X is chloride and Y is silver, the molar ratio of L-ornithine hydrochloride to silver benzoate may be greater than 1:1 so that an excess of chloride is present relative to silver. Accordingly, in some embodiments, the molar ratio of L-ornithine to benzoic acid is greater than about 1:1. Nevertheless, the additional chloride salt is not required to be derived from an L-ornithine salt (e.g., L-ornithine hydrochloride). For example, dilute solutions of hydrochloric acid may be added to the solution to further remove silver. Although it is not particularly limited when the additional X-containing salt is added, it is preferably added before the AgCl is initially isolated. As shown in Scheme 2, the L-ornithine benzoate can be reacted with a phenyl acetate salt of Formula IV to form L-ornithine phenyl acetate. For example, sodium phenyl acetate can be intermixed with a solution of L-ornithine benzoate to form L-ornithine phenyl acetate. Various salts of phenyl acetate may be used, and therefore Z in Formula IV can be any cation capable of forming a salt with phenyl acetate other than benzoic acid or L-ornithine. In some embodiments, Z can be a monoatomic cation, such as an alkali metal ion (e.g., Li + , Na + , and K + ) and other monovalent ions (e.g., Ag + ). Z may also be a polyatomic cation, such as ammonium, L-arginine, diethylamine, choline, ethanolamine, 1H-imidazole, trolamine, and the like. In some embodiments, Z is an inorganic ion. In some embodiments, Z is sodium. The relative amount of L-ornithine and phenyl acetate salts that are intermixed is also not limited; however the molar ratio of L-ornithine to phenyl acetate may optionally be in the range of about 10:90 and 90:10. In some embodiments, the molar ratio of L-ornithine to phenyl acetate can be in the range of about 30:70 and 30:70. In some embodiments, the molar ratio of L-ornithine to phenyl acetate can be in the range of about 40:60 and 60:40. In some embodiments, the molar ratio of L-ornithine to benzoic acid is about 1:1. The L-ornithine phenyl acetate of Formula V may then be isolated from solution using known techniques. For example, by evaporating any solvent until the L-ornithine phenyl acetate crystallizes, or alternatively by the adding an anti-solvent miscible in the L-ornithine phenyl acetate solution until the L-ornithine phenyl acetate precipitates from solution. Another possible means for isolating the L-ornithine phenyl acetate is to adjust the temperature of the solution (e.g., lower the temperature) until the L-ornithine phenyl acetate precipitates. As will be discussed in further detail in a later section, the method of isolating the L-ornithine phenyl acetate affects the crystalline form that is obtained. The isolated L-ornithine phenyl acetate may be subjected to various additional processing, such as drying and the like. In some embodiments, L-ornithine phenyl acetate may be subsequently intermixed with a dilute HCl solution to precipitate residual silver. The L-ornithine phenyl acetate may again be isolated from solution using similar methods disclosed above. As would be appreciated by a person of ordinary, guided by the teachings of the present application, L-ornithine phenyl acetate may similarly be prepared using an intermediate salt other than L-ornithine benzoate. Thus, for example, L-ornithine, or a salt thereof (e.g., L-ornithine hydrochloride), can be intermixed with a solution having acetic acid. L-Ornithine acetate may then be intermixed with phenyl acetic acid, or a salt thereof (e.g., sodium phenyl acetate), to obtain L-ornithine phenyl acetate. Scheme 4 illustrates an exemplary process of forming L-ornithine phenyl acetate using L-ornithine acetate as an intermediate salt. In some embodiments, the intermediate salt can be a pharmaceutically acceptable salt of L-ornithine. For example, the intermediate L-ornithine salt can be an acetate, aspartate, formate, oxalate, bicarbonate, carbonate, bitrate, sulfate, nitrate, isonicotinate, salicylate, citrate, tartrate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzensulfonate, p-toluenesulfonate, pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate) or phosphate. The free acid of the intermediate is preferably a weaker acid relative to phenyl acetic acid. In some embodiments, the intermediate is an L-ornithine salt with an anion component that exhibits a pK a value that is higher than the pK a value of phenyl acetic acid. As an example, for L-ornithine acetate, acetic acid and phenyl acetic acid exhibit pK a values of about 4.76 and 4.28, respectively. L-Ornithine phenyl acetate may also be prepared, in some embodiments, without forming an intermediate salt, such as L-ornithine benzoate. Scheme 4 illustrates an exemplary process for preparing L-ornithine phenyl acetate without an intermediate salt. A pH modifier may be added to a solution of L-ornithine salt (e.g., as illustrated in Scheme 4 by the compound of Formula I) until a salt precipitates from solution, where the salt is not an L-ornithine salt. As an example, sodium methoxide (NaOMe) can be added to a solution of L-ornithine hydrochloride until sodium chloride precipitates from solution to leave a free base of L-ornithine. The precipitate may optionally be isolated from solution using known techniques, such as filtration, centrifugation, and the like. The free base of L-ornithine (e.g., as illustrated in Scheme 4 by the compound of Formula I-a) may be intermixed with phenyl acetic acid, or a salt thereof (e.g., as illustrated in Scheme 4 by the compound of Formula IV), to obtain L-ornithine phenyl acetate. The L-ornithine phenyl acetate of Formula V may then be isolated as previously described. A pH modifier can include a basic compound, or anhydrous precursor thereof, and/or a chemically protected base. Non-limiting examples of pH modifiers include sodium hydroxide, potassium hydroxide, sodium methoxide, potassium t-butoxide, sodium carbonate, calcium carbonate, dibutylamine, tryptamine, sodium hydride, calcium hydride, butyllithium, ethylmagnesium bromide and combinations thereof. Also, the amount of pH modifier to be added is not particularly limited; however the molar ratio of L-ornithine to pH modifier may optionally be in the range of about 10:90 and 90:10. In some embodiments, the molar ratio of L-ornithine to pH modifier can be in the range of about 30:70 and 30:70. In some embodiments, the molar ratio of L-ornithine to pH modifier can be in the range of about 40:60 and 60:40. In some embodiments, the molar ratio of L-ornithine to pH modifier is about 1:1. The pH modifier may, in some embodiments be added to adjust the pH value to at least about 8.0; at least about 9.0; or at least about 9.5. Another process for forming L-ornithine phenyl acetate, in some embodiments, includes reacting an alkali metal salt of L-ornithine with a phenyl acetate salt. As an example, L-ornithine hydrochloride may be intermixed with silver phenyl acetate and a solvent. AgCl may then precipitate and is optionally isolated from the solution. The remaining L-ornithine phenyl acetate can also be isolated using known methods. This process can be completed using generally the same procedures and conditions outlined above. For example, the relative molar amounts of L-ornithine to phenyl acetate can be 10:90 to 90:10; 30:70 to 70:30; 40:60 to 60:40; or about 1:1. Also, the L-ornithine phenyl acetate may be isolated by evaporating the solvent, adding an anti-solvent, and/or reducing the temperature. Compositions of L-Ornithine Phenyl Acetate Also disclosed herein are compositions of L-ornithine phenyl acetate. The compositions of the present application advantageously have low amounts of inorganic salts, particularly alkali metal salts and/or halide salts, and therefore are particularly suited for oral and/or intravenous administration to patients with hepatic encephalopathy. Meanwhile, these compositions may exhibit similar stability profiles compared to other salts (e.g., mixtures of L-ornithine hydrochloride and sodium phenyl acetate). The compositions may, in some embodiments, be obtained by one of the processes disclosed in the present application. For example, any of the disclosed processes using L-ornithine benzoate as an intermediate may yield the compositions of the present application. The compositions, in some embodiments, can include a crystalline form of L-ornithine phenyl acetate (e.g., Forms I, II, III and/or V disclosed herein). In some embodiments, the composition may include at least about 20% by weight of a crystalline form of L-ornithine phenyl acetate (preferably at least about 50% by weight, and more preferably at least about 80% by weight). In some embodiments, the composition consists essentially of a crystalline form of L-ornithine phenyl acetate. In some embodiments, the composition includes a mixture of at least two (e.g., two, three or four forms) of Forms I, II, III, and V. The compositions, in some embodiments, include Form II. For example, the compositions may include at least about 20%; at least about 50%; at least about 90%; at least about 95%; or at least about 99% of Form II. Similarly, the compositions may also include, for example, Forms I, III or V. The compositions may optionally include at least about 20%; at least about 50%; at least about 90%; at least about 95%; or at least about 99% of Forms I, II, III and/or V. Also within the scope of the present application are amorphous forms of L-ornithine phenyl acetate. Various methods are known in the art for preparing amorphous forms. For example, a solution of L-ornithine phenyl acetate may be dried under vacuum by lyophilization to obtain an amorphous composition. See P.C.T. Application WO 2007/058634, which published in English and designates the U.S., and is hereby incorporated by reference for disclosing methods of lyophilization. It is preferred that the composition have low amounts (if any) of alkali and halogen ions or salts, particular sodium and chloride. In some embodiments, the composition comprises no more than about 100 ppm of alkali metals (preferably no more than about 20 ppm, and most preferably no more than about 10 ppm). In some embodiments, the composition comprises no more than about 100 ppm of sodium (preferably no more than about 20 ppm, and most preferably no more than about 10 ppm). In some embodiments, the composition comprises no more than about 0.1% by weight of halides (preferably no more than about 0.01% by weight). In some embodiments, the composition comprises no more than about 0.1% by weight of chloride (preferably no more than about 0.01% by weight). The reduced content of alkali metals and halides provides a composition suitable for preparing concentrated isotonic solutions. As such, these compositions can be more easily administered intravenously compared to, for example, administering mixtures of L-ornithine hydrochloride and sodium phenyl acetate. In some embodiments, an about 45 to about 55 mg/mL solution of L-ornithine phenyl acetate in water (preferably about 50 mg/mL) is isotonic with body fluids (e.g., the solution exhibits an osmolality in the range of about 280 to about 330 mOsm/kg). The compositions may also include residual amounts of the anion from an intermediate salt formed during the process of making the L-ornithine phenyl acetate composition. For example, some of the processes disclosed herein yield compositions having benzoic acid or a salt thereof. In some embodiments, the composition comprises at least about 0.01% by weight benzoic acid or a salt thereof (preferably at least about 0.05% by weight, and more preferably about 0.1% by weight). In some embodiments, the composition comprises no more than about 3% by weight benzoic acid or a salt thereof (preferably no more than about 1% by weight, and more preferably no more than about 0.5% by weight). In some embodiments, the composition includes a salt, or an acid thereof, in the range of about 0.01% to about 3% by weight (preferably about 0.1% to about 1%), wherein the salt is selected from acetate, aspartate, formate, oxalate, bicarbonate, carbonate, bitrate, sulfate, nitrate, isonicotinate, salicylate, citrate, tartrate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzensulfonate, p-toluenesulfonate, pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate) or phosphate. Similarly, a composition prepared using an acetate intermediate may have residual amounts of acetic acid or acetate. In some embodiments, the composition includes at least about 0.01% by weight acetic acid or acetate (preferably at least about 0.05% by weight, and more preferably about 0.1% by weight). In some embodiments, the composition includes no more than about 3% by weight acetic acid or acetate (preferably no more than about 1% by weight, and more preferably no more than about 0.5% by weight). The compositions may also include low amounts of silver. Exemplary processes disclosed herein utilize, for example, silver benzoate, but still yield compositions with surprisingly low amounts of silver. Thus, in some embodiments, the composition includes no more than about 600 ppm silver (preferably no more than about 100 ppm, and more preferably no more than about 65 ppm). In some embodiments, the composition includes at least about 10 ppm silver (alternatively at least about 20 or 25 ppm silver). Pharmaceutical Compositions The compositions of L-ornithine phenyl acetate of the present application may also be formulated for administration to a subject (e.g., a human). L-Ornithine phenyl acetate, and accordingly the compositions disclosed herein, may be formulated for administration with a pharmaceutically acceptable carrier or diluent. L-ornithine phenyl acetate may thus be formulated as a medicament with a standard pharmaceutically acceptable carrier(s) and/or excipient(s) as is routine in the pharmaceutical art. The exact nature of the formulation will depend upon several factors including the desired route of administration. Typically, L-ornithine phenyl acetate is formulated for oral, intravenous, intragastric, subcutaneous, intravascular or intraperitoneal administration. The pharmaceutical carrier or diluent may be, for example, water or an isotonic solution, such as 5% dextrose in water or normal saline. Solid oral forms may contain, together with the active compound, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents, e.g. starches, gum arabic, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g. starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents, such as lecithin, polysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. Such pharmaceutical preparations may be manufactured in known manners, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes. Liquid dispersions for oral administration may be syrups, emulsions or suspensions. The syrups may contain as carriers, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol. Suspensions and emulsions may contain a carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol. The suspensions or solutions for intramuscular injections may contain, together with L-ornithine phenyl acetate, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidocaine hydrochloride. The medicament may consist essentially of L-ornithine phenyl acetate and a pharmaceutically acceptable carrier. Such a medicament therefore contains substantially no other amino acids in addition to L-ornithine and phenyl acetate. Furthermore, such a medicament contains insubstantial amounts of other salts in addition to L-ornithine phenyl acetate. Oral formulations may generally include dosages of L-ornithine phenyl acetate in the range of about 500 mg to about 100 g. Accordingly, in some embodiments, the oral formulation includes the L-ornithine phenyl acetate compositions disclosed herein in the range of about 500 mg to about 50 g. In some embodiments, the oral formulation is substantially free of alkali metal salts and halides (e.g., contains no more than trace amounts of alkali metal salts and halides). Intravenous formulations may also generally include dosages of L-ornithine phenyl acetate in the range of about 500 mg to about 100 g (preferably about 1 g to about 50 g). In some embodiments, the intravenous formulation is substantially free of alkali metal salts and halides (e.g., contains no more than trace amounts of alkali metal salts and halides). In some embodiments, the intravenous formulation has a concentration of about 5 to about 300 mg/mL of L-ornithine phenyl acetate (preferably about 25 to about 200 mg/mL, and more preferably about 40 to about 60 mg/mL). The composition, or medicament containing said composition, may optionally be placed is sealed packaging. The sealed packaging may reduce or prevent moisture and/or ambient air from contacting the composition or medicament. In some embodiments, the packaging includes a hermetic seal. In some embodiments, the packaging sealed under vacuum or with an inert gas (e.g., argon) within the sealed package. Accordingly, the packaging can inhibit or reduce the rate of degradation for the composition or medicament stored within the packaging. Various types of sealed packaging are known in the art. For example, U.S. Pat. No. 5,560,490, is hereby incorporate by reference in its entirety, discloses an exemplary sealed package for medicaments. Compositions with Improved Density Applicants have surprisingly found that compositions with greater density may be obtained by applying sufficient pressure to compositions having Form I (described below) to induce a transition to Form II (described below). For example, applying 3 tons of force for 90 minutes to Forms I and II yield densities of 1.197 kg/m 3 and 1.001 kg/m 3 , respectively. Surprisingly, Form I converted to Form II under these conditions; therefore the greater density appears to be explained by the different crystalline form as the starting material. Accordingly, disclosed herein are methods of increasing the density of an L-ornithine phenyl acetate composition having Form I by applying pressure to the composition sufficient to induce a transition to Form II. The appropriate amount of force or pressure to induce the phase change may vary with the amount of time the force or pressure is applied. Thus, a person of ordinary skill, guided by the teachings of the present application, can determine appropriate amounts of pressure and time to induce the phase change. In some embodiments, at least about 1 ton of force is applied (preferably at least about 2 tons, and more preferably about 3 tons). In some embodiments, at least about 500 psi of pressure is applied (preferably at least about 1000 psi, and more preferably at least about 2000 psi). The amount of time for applying pressure is not particularly limited, and as discussed above, will vary depending upon the amount time. For example, when applying large forces (e.g., 10 tons) to a typical tablet-sized punch, the time may be about 1 second or less. In some embodiments, the time for apply pressure is a predetermined time. The time may be, for example, about 0.1 seconds; about 1 second; at least about 1 minute; at least about 5 minutes; or at least about 20 minutes. In some embodiments, the composition includes at least about 10% by weight of Form I. In some embodiments, the composition includes at least about 30% by weight of Form I. Without being bound to any particular theory, Applicants believe the greater density may result, at least in part, from ethanol solvate component present in Form I. Applying pressure to the solvate may facilitate forming a denser structure with fewer defects (e.g., grain boundaries). Consequently, in some embodiments, methods of increasing the density of an L-ornithine phenyl acetate composition having solvate components include applying pressure to the composition sufficient to induce a transition to Form II. In some embodiments, the pressure is at least about 500 psi (preferably at least about 1000 psi, and more preferably at least about 2000 psi). In some embodiments, the time for apply pressure is a predetermined time. In some embodiments, the composition includes at least about 10% of the solvate form (preferably at least about 30%, and more preferably at least about 50%). The compositions of L-ornithine phenyl acetate disclosed herein may therefore have higher densities compared to compositions obtain by, for example, precipitating a crystalline form. In some embodiments, the composition has a density of at least about 1.1 kg/m 3 (preferably at least about 1.15 kg/m 3 , and more preferably at least about 1.18 kg/m 3 ). In some embodiments, the composition has a density of no more than about 1.3 kg/m 3 (preferably no more than about 1.25 kg/m 3 , and more preferably no more than about 1.22 kg/m 3 ). In some embodiments, the composition has a density of about 1.2 kg/m 3 . Crystalline Forms of L-Ornithine Phenyl Acetate Also disclosed herein are crystalline forms of L-ornithine phenyl acetate, and in particular, crystalline Form I, Form II, Form III, and Form V. L-Ornithine phenyl acetate may, in some embodiments, be obtained using the processes disclosed above and then crystallized using any of the methods disclosed herein. Form I The precise conditions for forming crystalline Form I may be empirically determined and it is only possible to give a number of methods which have been found to be suitable in practice. Thus, for example, crystalline Form I may generally be obtained by crystallizing L-ornithine phenyl acetate under controlled conditions. As an example, precipitating L-ornithine phenyl acetate from a saturated solution by adding ethanol at reduced temperatures (e.g., 4° or −21° C.). Exemplary solvents for the solution that yield crystalline Form I upon adding ethanol include, but are not limited to, cyclohexanone, 1-propanol, dimethylcarbonate, N-methylpyrrolidine (NMP), diethyl ether, 2-butanol, cumene, ethyl formate, isobutyl acetate, 3-methyl-1-butanol, and anisole. Accordingly, in the context of the processes for making L-ornithine phenyl acetate disclosed above, the process can yield Form I by utilizing particular isolation methods. For example, L-ornithine phenyl acetate may be isolated by adding ethanol at reduced temperature to yield Form I. Crystalline Form I was characterized using various techniques which are described in further detail in the experimental methods section. FIG. 1 shows the crystalline structure of Form I as determined by X-ray powder diffraction (XRPD). Form I, which may be obtained by the methods disclosed above, exhibits characteristic peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ. Thus, in some embodiments, a crystalline form of L-ornithine phenyl acetate has one or more characteristic peaks (e.g., one, two, three, four or five characteristic peaks) selected from approximately 4.9°, 13.2°, 17.4°, 20.8°, and 24.4° 2θ. As is well understood in the art, because of the experimental variability when X-ray diffraction patterns are measured on different instruments, the peak positions are assumed to be equal if the two theta (28) values agree to within 0.2° (i.e., ±0.2°). For example, the United States Pharmacopeia states that if the angular setting of the 10 strongest diffraction peaks agree to within ±0.2° with that of a reference material, and the relative intensities of the peaks do not vary by more than 20%, the identity is confirmed. Accordingly, peak positions within 0.2° of the positions recited herein are assumed to be identical. FIG. 2 shows results obtained by differential scanning calorimetry (DSC) for Form I. These results indicate an endotherm at 35° C., which is possibly associated with a desolvation and/or dehydration to Form II. A second transition at about 203° C. indicates the melting point for the crystal. To explore the possible existence of a desolvation and/or dehydration transition, Form I was analyzed by thermogravimetric gravimetric/differential thermal analysis (TG/DTA), which is shown in FIG. 3 . Form I exhibits a 11.28% weight loss at about 35° C., and therefore these results further suggest that Form I exhibits a desolvation and/or dehydration transition at about 35° C. The melting point of about 203° C. could also be observed by TGA testing. Accordingly, in some embodiments, the crystalline form of L-ornithine phenyl acetate is characterized by differential scanning calorimetry as having an endotherm at about at about 35° C. In some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a weight loss of about 11% at about 35° C., as determined by TGA. In some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a melting point of about 203° C. FIG. 4 shows nuclear magnetic resonance (NMR) integrals and chemical shifts for Form I. The integrals confirm the presence of L-ornithine phenyl acetate: 7.5 (aromatic CH), 3.8 (CH adjacent to NH 2 ), 3.6 (CH 2 unit of phenyl acetate), 3.15 (CH 2 adjacent to NH 2 ) and 1.9 (aliphatic CH 2 units) ppm (integrals: 5:1:2:2:4 protons; 1.2, 0.25, 0.5, 0.5, 1.0). Amine protons and hydroxyl protons were not observed due to proton exchange at both the zwitterion and site of salt formation. Meanwhile, FIG. 5 shows dynamic vapor sorption (DVS) results for Form I, and show a water uptake of about 0.2% by weight. XRPD results following DVA analysis (not shown) confirm that Form I did not transition to a different polymorph. Form I can therefore be characterized as non-hygroscopic and stable over a wide range of humidity. A 7-day stability study of Form I at 40° C./75% RH indicated that a transformation to Form II occurred under these conditions. Form I also converts to Form II at elevated temperatures (e.g., 80° or 120° C.), with or without applying a vacuum, after 7 or 14 days. Accordingly, Form I is metastable. Single crystal x-ray diffraction (SXRD) was also used to determine the structure of Form I at −20° and −123° C., and the results are summarized in TABLES 1 and 2. The results confirm that Form I is a solvate having ethanol and water molecules within the unit cell. In some embodiments, a crystalline form of L-ornithine phenyl acetate can be represented by the formula C 15 H 28 N 2 O 6 . In some embodiments, a crystalline form of L-ornithine phenyl acetate can be represented by the formula [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]EtOH.H 2 O. In some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following: unit cell dimensions of a=5.3652(4) Å, b=7.7136(6) Å, c=20.9602(18) Å, α=90°, β=94.986(6)°, γ=90°; a monoclinic crystal system, and a P2 1 space group. TABLE 1Crystallographic Data of Form I Collected at −20° C.Empirical FormulaC 15 H 28 N 2 O 6 or[C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]EtOH•H 2 OFormula Weight332.39Crystal SystemMonoclinicSpace GroupP2 1Unit Cell Dimensionsa = 5.3652(4) Å α = 90°b = 7.7136(6) Å β = 94.986(6)°c = 20.9602(18) Å γ = 90°Volume864.16(12) Å 3Number of Reflections1516 (2.5° < θ < 28°)Density (calculated)1.277 mg/cm 3 TABLE 2Crystallographic Data of Form I Collected at −123° C.Empirical FormulaC 15 H 28 N 2 O 6 or[C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]EtOH•H 2 OFormula Weight332.39Crystal SystemMonoclinicSpace GroupP2 1Unit Cell Dimensionsa = 5.3840(9) Å α = 90°b = 7.7460(12) Å β = 95.050(12)°c = 21.104(4) Å γ = 90°Volume876.7(3) Å 3Number of Reflections1477 (2.5° < θ < 18°)Density (calculated)1.259 mg/cm 3 Form II The precise conditions for forming crystalline Form II may be empirically determined and it is only possible to give a number of methods which have been found to be suitable in practice. Thus, for example, crystalline Form II may be prepared by crystallization under controlled conditions. Crystalline Form II can be prepared by, for example, evaporating a saturated organic solution of L-ornithine phenyl acetate. Non-limiting examples of organic solutions that may be used to obtain Form II include ethanol, acetone, benzonitrile, dichloromethane (DCM), dimethyl sulfoxide (DMSO), ethyl acetate (EtOAc), acetonitrile (MeCN), methyl acetate (MeOAc), nitromethane, tert-butyl methyl ether (TBME), tetrahydrofuran, and toluene. Other solvents may yield a mixture of Form I and II, such as, but not limited to, 1,4 dioxane, 1-butanol, cyclohexane, IPA, THF, MEK, MeOAc and water. Form II can also be obtained by precipitating L-ornithine phenyl acetate from a saturated organic solution by adding an anti-solvent for L-ornithine phenyl acetate, such as IPA. Form II may be precipitated over a broad range of temperatures (e.g., room temperature, 4° C., and −21° C.). Non-limiting examples of suitable solvents for the saturated organic solution include cyclohexanone, 1-propanol, dimethyl carbonate, N-methylpyrrolidone (NMP), diisopropyl ether, diethyl ether, ethylene glycol, dimethylformamide (DMF), 2-butanol, cumene, isobutyl acetate, 3-methyl-1-butanol, and anisole. Alternatively, the same listed solvents (e.g., cyclohexanone) can be used to form a solution of L-ornithine phenyl acetate, and Form II may be precipitated by adding ethanol at ambient conditions. As another example, Form II may also be obtained by forming a slurry of L-ornithine phenyl acetate with the listed organic solvents and cycling the temperature between 25° and 40° C. every 4 hours for about 18 cycles (or 72 hours). Accordingly, in the context of the processes for making L-ornithine phenyl acetate disclosed above, the process can yield Form II by utilizing particular isolation methods. For example, L-ornithine phenyl acetate may by isolated by adding IPA, or evaporating the organic solvent, to yield Form II. FIG. 6 shows the crystalline structure of Form II as determined by XRPD. Form II, which may be obtained by the methods disclosed above, exhibits characteristic peaks at approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ. Thus, in some embodiments, a crystalline form of L-ornithine phenyl acetate has one or more characteristic peaks (e.g., one, two, three, four, five or six characteristic peaks) selected from approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.12° θ. FIG. 7 shows results obtained by differential scanning calorimetry (DSC) for Form II. These results indicate a melting point of about 202° C., which is approximately the same as the melting point for Form I. This suggests that Form I transitions to Form II upon heating above about 35° C. Form II was also analyzed using TG/DTA, as shown in FIG. 8 , and exhibits an about 9.7% weight loss associated with residual solvent. The melting point of about 202° C. could also be observed by TGA testing. Accordingly, in some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a melting point of about 202° C. A 7-day stability study of Form II at 40° C./75% RH failed to produce an observable phase change. In fact, Form II was stable over 14 days when exposed to elevated temperatures, varying pHs, UV light or oxygen. Accordingly, Form II is considered stable. FIG. 9 shows nuclear magnetic resonance (NMR) integrals and chemical shifts for Form II. The integrals confirm the presence of L-ornithine phenyl acetate: 7.5 (aromatic CH), 3.8 (CH adjacent to NH2), 3.6 (CH2 unit of phenylacetate), 3.15 (CH2 adjacent to NH2) and 1.9 (aliphatic CH2 units) ppm (integrals: 5:1:2:2:4 protons; 7.0, 1.4, 2.9, 3.0, 5.9). Amine protons and hydroxyl protons were not observed due to proton exchange at both the zwitterion and site of salt formation. Meanwhile, FIG. 10 shows dynamic vapor sorption (DVS) results for Form II, and show a water uptake of about 0.3% by weight. XRPD results following DVA analysis (not shown) confirm that Form II did not transition to a different polymorph. Form II can therefore be characterized as non-hygroscopic and stable over a wide range of humidity. Single crystal x-ray diffraction (SXRD) was also used to determine the structure of Form II at 23° and −123° C., and the results are summarized in TABLES 3 and 4. The results demonstrate that Form II is anhydrous and therefore structurally different from Form I. In some embodiments, a crystalline form of L-ornithine phenyl acetate can be represented by the formula C 13 H 20 N 2 O 4 . In some embodiments, a crystalline form of L-ornithine phenyl acetate can be represented by the formula [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]. In some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following: unit cell dimensions of a=6.594(2) Å, α=90°, b=6.5448(18) Å, β=91.12(3)°, c=31.632(8) Å, γ=90°; a monoclinic crystal system; and a P2 1 space group. TABLE 3Crystallographic Data of Form II Collected at 23° C.Empirical FormulaC 13 H 20 N 2 O 4 or [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]Formula Weight268.31Crystal SystemMonoclinicSpace GroupP2 1Unit Cell Dimensionsa = 6.594(2) Å α = 90°b = 6.5448(18) Å β = 91.12(3)°c = 31.632(8) Å γ = 90°Volume1364.9(7) Å 3Number of Reflections3890 (3° < θ < 20.5°)Density (calculated)1.306 mg/cm 3 TABLE 4Crystallographic Data of Form II Collected at −123° C.Empirical FormulaC 15 H 28 N 2 O 6 or [C 5 H 13 N 2 O 2 ][C 8 H 7 O 2 ]Formula Weight332.39Crystal SystemMonoclinicSpace GroupP2 1Unit Cell Dimensionsa = 5.3652(4) Å α = 90°b = 7.7136(6) Å β = 94.986(6)°c = 20.9602(18) Å γ = 90°Volume864.16(12) Å 3Number of Reflections1516 (2.5° < θ < 28°)Density (calculated)1.277 mg/cm 3 Form III The precise conditions for forming crystalline Form III may be empirically determined and it is only possible to give a number of methods which have been found to be suitable in practice. Thus, for example, Form III may be obtained by placing a saturated solution of L-ornithine phenyl acetate in a cooled temperature environment of about −21° C., where the solution is a mixture of acetone and water (e.g., equal parts volume of acetone and water). As another example, adding IPA to a saturated solution of L-ornithine phenyl acetate in 2-butanol can yield Form III when completed at ambient conditions. Furthermore, Form III may be obtained, for example, by adding IPA to a saturated solution of L-ornithine phenyl acetate in isobutyl acetate when completed at reduced temperatures of about −21° C. Accordingly, in the context of the processes for making L-ornithine phenyl acetate disclosed above, the process can yield Form III by utilizing particular solvents and isolation methods. For example, L-ornithine phenyl acetate may be formed within a mixture of acetone and water, and subsequently placed in a cool environment of about −21° C. to yield Form III. FIG. 11 shows the crystalline structure of Form III as determined by XRPD. Form III, which may be obtained by the methods disclosed above, exhibits characteristic peaks at approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ. Thus, in some embodiments, a crystalline form of L-ornithine phenyl acetate has one or more characteristic peaks (e.g., one, two, three, four, five or six characteristic peaks) selected from approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ. FIG. 12 shows results obtained by differential scanning calorimetry (DSC) for Form III. These results indicate a melting point of about 203° C., which is approximately the same as the melting points for Form I and Form II. Additionally, Form III exhibits an endotherm at about 40° C. Form III was also analyzed using TG/DTA, as shown in FIG. 13 , and exhibits no significant weight loss before the melting point. Form III may therefore be characterized as anhydrous. The melting point of about 203° C. could also be observed by TGA testing. Accordingly, in some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a melting point of about 203° C. In some embodiments, a crystalline form of L-ornithine phenyl acetate is characterized by differential scanning calorimetry as having an endotherm at about 40° C. In some embodiments, a crystalline form of L-ornithine phenyl acetate is anhydrous. A 7-day stability study of Form III at 40° C./75% RH indicated that a transformation to Form II occurred under these conditions. In contrast, Form II is stable at elevated temperatures, with or without vacuum, for periods of 7 or 10 days. Accordingly, Form III is most likely metastable, but more stable than Form I. FIG. 14 shows nuclear magnetic resonance (NMR) integrals and chemical shifts for Form III. The integrals confirm the presence of L-ornithine phenyl acetate: 7.5 (aromatic CH), 3.8 (CH adjacent to NH2), 3.6 (CH2 unit of phenyl acetate), 3.15 (CH2 adjacent to NH2) and 1.9 (aliphatic CH2 units) ppm (integrals: 5:1:2:2:4 protons; 4.2, 0.8, 1.7, 1.7, 3.0). Amine protons and hydroxyl protons were not observed due to proton exchange at both the zwitterion and site of salt formation. Meanwhile, FIG. 15 shows dynamic vapor sorption (DVS) results for Form III, and show a water uptake of about 2.0% by weight. XRPD results following DVS analysis (not shown) confirm that Form III did not transition to a different polymorph. Form III therefore exhibits greater water uptake compared to Forms I and II; however Form III is still characterized as non-hygroscopic and stable over a wide range of humidity at room temperature. Form V The precise conditions for forming crystalline Form V may be empirically determined and it is only possible to give a number of methods which have been found to be suitable in practice. Thus, for example, Form V may be obtained by placing a saturated solution of L-ornithine phenyl acetate in a cooled temperature environment of about −21° C., where the solution is cyclohexanone. As another example, the same saturated solution may yield Form V when evaporating the solvent. Form V also forms from saturated solutions of L-ornithine phenyl acetate having diisopropyl ether as a solvent. For example, a saturated solution having a solvent ratio of about 1 to 2 of diisopropyl ether and IPA will yield Form V when placed in a cooled temperature environment of about 4° C. Similarly, a solution having only the solvent diisopropyl ether can yield Form V when placed in a cooled temperature environment of about −21° C. FIG. 16 shows the crystalline structure of Form V as determined by XRPD. Form V, which may be obtained by the methods disclosed above, exhibits characteristic peaks at approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. Thus, in some embodiments, a crystalline form of L-ornithine phenyl acetate has one or more characteristic peaks (e.g., one, two, three, four, or five characteristic peaks) selected from approximately 13.7°, 17.4°, 19.8°, 20.6° and 23.7° 2θ. FIG. 17 shows results obtained by differential scanning calorimetry (DSC) for Form V. These results indicate a melting point of about 196° C., which is below the melting point of other forms. Form V also exhibits an endotherm at about 174° C. Form V was also analyzed using thermal gravimetric analysis (TGA), as shown in FIG. 18 , and exhibits no significant weight loss before the melting point. Form V may therefore be characterized as anhydrous. The melting point of about 196° C. could also be observed by TGA testing. Accordingly, in some embodiments, a crystalline form of L-ornithine phenyl acetate exhibits a melting point of about 196° C. In some embodiments, a crystalline form of L-ornithine phenyl acetate is characterized by differential scanning calorimetry as having an endotherm at about 174° C. In some embodiments, a crystalline form of L-ornithine phenyl acetate is anhydrous. FIG. 19 shows nuclear magnetic resonance (NMR) integrals and chemical shifts for Form V. The integrals confirm the presence of L-ornithine phenyl acetate: 7.5 (aromatic CH), 3.8 (CH adjacent to NH2), 3.6 (CH2 unit of phenyl acetate), 3.15 (CH2 adjacent to NH2) and 1.9 (aliphatic CH2 units) ppm (integrals: 5:1:2:2:4 protons; 4.2, 0.8, 1.7, 1.7, 3.0). Amine protons and hydroxyl protons were not observed due to proton exchange at both the zwitterion and site of salt formation. Meanwhile, FIG. 19 shows dynamic vapor sorption (DVS) results for Form V, and show a water uptake of about 0.75% by weight. XRPD results following DVS analysis (not shown) suggest that Form V transitioned to Form II, but the chemical composition was unchanged. Form V is therefore characterized as non-hygroscopic, but not stable over a wide range of humidity. A 7-day stability study of Form V at 40° C./75% RH indicated that a transformation to Form II occurred under these conditions; however the chemical composition was unchanged. Accordingly, Form V is most likely metastable. Methods of Treating Liver Decompensation or Hepatic Encephalopathy L-Ornithine phenyl acetate, and accordingly any of the compositions of L-ornithine phenyl acetate disclosed herein, may be administered to a subject for treating or ameliorating the onset of liver decompensation or hepatic encephalopathy. L-Ornithine phenyl acetate can thus be administered to improve the condition of a subject, for example a subject suffering from chronic liver disease following a precipitating event. As another example, L-ornithine phenyl acetate may be administered to combat or delay the onset of liver decompensation or hepatic encephalopathy. L-Ornithine phenyl acetate may be administered in combination to a subject for treatment of hepatic encephalopathy. L-Ornithine phenyl acetate may be administered to improve the condition of a patient suffering from hepatic encephalopathy. L-Ornithine phenyl acetate may be administered to alleviate the symptoms associated with hepatic encephalopathy. L-Ornithine phenyl acetate may be administered to combat hepatic encephalopathy. L-Ornithine phenyl acetate may be administered to prevent or reduce the likelihood of an initial hepatic encephalopathic episode in a person at risk for hepatic encephalopathic episodes. L-Ornithine phenyl acetate may be administered to lessen the severity of an initial hepatic encephalopathic episode in a person at risk for hepatic encephalopathic episodes. L-Ornithine phenyl acetate may be administered to delay an initial hepatic encephalopathic episode in a person at risk for hepatic encephalopathic episodes. Development of liver decompensation and hepatic encephalopathy commonly involves “precipitating events” (or “acute attacks”). Such precipitating events include gastrointestinal bleeding, infection (sepsis), portal vein thrombosis and dehydration. The onset of such an acute attack is likely to lead to hospitalization. The patient may suffer one of these acute attacks or a combination of these acute attacks. A subject who has had or is suspected of having had an acute attack is treated according to the invention with L-ornithine phenyl acetate to prevent or reduce the likelihood of progression of the liver to the decompensated state. Consequently, L-ornithine phenyl acetate can prevent or reduce the likelihood of the medical consequences of liver decompensation such as hepatic encephalopathy. L-Ornithine phenyl acetate may be used to preserve liver function. Use of L-ornithine phenyl acetate may thus extend the life of a patient with liver disease. In one embodiment, the metabolic consequences of a gastrointestinal bleed such as hyperammonemia, hypoisoleucemia and reduced protein synthesis in the post-bleeding period are prevented. Typically, treatment of subjects may begin as soon as possible after the onset or the suspected onset of a precipitating event (acute attack). Preferably, treatment of the subject begins prior to repeated acute attacks. More preferably, treatment of the subject begins following the first acute attack. Thus, in some embodiments, the subject treated with L-ornithine phenyl acetate is identified as having the onset or the suspected onset of a precipitating event (acute attack). Treatment is typically given promptly after the start of an acute attack. Treatment may begin after the symptom(s) of an acute attack or suspected acute attack have been detected e.g. by a medic such as a physician, a paramedic or a nurse. Treatment may begin upon hospitalization of the subject. Treatment may thus begin within 6 hours, within 3 hours, within 2 hours or within 1 hour after the symptom(s) of an acute attack or suspected acute attack have been detected. Treatment of the subject may therefore begin from 1 to 48 hours, for example from 1 to 36 hours or from 1 to 24 hours after the symptom(s) of an acute attack or suspected acute attack have been detected. Treatment may occur for up to 8 weeks, for example up to 6 weeks, up to 4 weeks or up to 2 weeks after the symptom(s) of an acute attack or suspected acute attack have been detected. Treatment may therefore occur for up to 48 hours, for example for up to 36 hours or for up to 24 hours after the symptom(s) of an acute attack or suspected acute attack have been detected. Typically, treatment occurs to the time when recovery from the acute precipitating event is evident. L-Ornithine phenyl acetate may also be used to treat or ameliorate hyperammonemia. Thus, L-ornithine phenyl acetate may be administered to patients identified as having excess ammonia levels in the blood, or patients exhibiting symptoms of excess ammonia in the blood. L-Ornithine phenyl acetate may also be administered to reduce the risk of hyperammonemia. In some embodiments, L-ornithine phenyl acetate can be administered daily, for an indefinite period of time. For example, daily dosages may be administered for the life of the patient, or until a physician determines the patient no longer exhibits a risk for hyperammonemia. In some embodiments, a therapeutically effective amount of L-ornithine phenyl acetate is administered to reduce the risk of hyperammonemia. In some embodiments, a therapeutically effective amount of L-ornithine phenyl acetate is administered orally for the prophylaxis of hyperammonemia. A therapeutically effective amount of L-ornithine phenyl acetate is administered to the subject. As will be readily apparent to one skilled in the art, the useful in vivo dosage to be administered and the particular mode of administration will vary depending upon the age, weight, the severity of the affliction, and mammalian species treated, the particular compounds employed, and the specific use for which these compounds are employed. (See e.g., Fingl et al. 1975, in “The Pharmacological Basis of Therapeutics”, which is hereby incorporated herein by reference in its entirety, with particular reference to Ch. 1, p. 1). The determination of effective dosage levels, that is the dosage levels necessary to achieve the desired result, can be accomplished by one skilled in the art using routine pharmacological methods. Typically, human clinical applications of products are commenced at lower dosage levels, with dosage level being increased until the desired effect is achieved. Alternatively, acceptable in vitro studies can be used to establish useful doses and routes of administration of the compositions identified by the present methods using established pharmacological methods. A typical dose of L-ornithine phenyl acetate may be from about 0.02 to about 1.25 g/kg of bodyweight (preferably from about 0.1 to about 0.6 g/kg of bodyweight). A dosage may therefore be from about 500 mg to about 50 g (preferably about 5 g to about 40 g, and more preferably about 10 g to about 30 g). A single daily dose may be administered. Alternatively, multiple doses, for example two, three, four or five doses may be administered. Such multiple doses may be administered over a period of one month or two weeks or one week. In some embodiments, a single dose or multiple doses such as two, three, four or five doses may be administered daily. Examples and Experimental Methods Additional embodiments are disclosed in further detail in the following examples, which are not in any way intended to limit the scope of the claims. X-Ray Powder Diffraction (XRPD) XRPD analysis was carried out on a Bruker D8 advance or Seimens D5000, scanning the samples between 4° and 50° 2θ. In embodiments using the Bruker D8 device, approximately 5 mg of a sample was gently compressed on the XRPD zero back ground single 96 well plate sample holder. The sample was then loaded into a Bruker D8-Discover diffractometer in transmission mode and analysed using the following experimental conditions. OperatorD8-DiscoverRaw Data OriginBRUKER-binary V3 (.RAW)Scan AxisGonioStart Position [°2θ.]4.0000End Position [°2θ.]49.9800Step Size [°2θ.]0.0200Scan Step Time [s]39.1393Scan TypeContinuousOffset [°2θ.]0.0000Divergence Slit TypeFixedDivergence Slit Size [°]2.0000Specimen Length [mm]10.00Receiving Slit Size [mm]0.1000Measurement Temperature [° C.]25.00Anode MaterialCuK-Alpha1 [Å]1.54060K-Alpha2 [Å]1.54443K-Beta [Å]1.39225K-A2/K-A1 Ratio0.50000Generator Settings40 mA, 40 kVDiffractometer TypeUnknownDiffractometer Number0Goniometer Radius [mm]250.00Dist. Focus-Diverg. Slit [mm]91.00Incident Beam MonochromatorNoSpinningNo In embodiments using the Seimens D5000 device, approximately 5 mg of sample was gently compressed on glass slide containing a thin layer of holding grease. The sample was then loaded into a Seimens D5000 diffractometer running in reflection mode and analysed, whilst spinning, using the following experimental conditions. Raw Data OriginSiemens-binary V2 (.RAW)Start Position [°2θ.]3.0000End Position [°2θ.]50.000Step Size [°2θ.]0.0200Scan Step Time [s]0.8Scan TypeContinuousOffset [°2θ.]0.0000Divergence Slit TypeFixedDivergence Slit Size [°]1.0000Specimen Length [mm]variousReceiving Slit Size [mm]0.2000Measurement Temperature [° C.]20.00Anode MaterialCuK-Alpha1 [Å]1.54060K-Alpha2 [Å]1.54443K-Beta [Å]1.39225K-A2/K-A1 Ratio0.50000 (nominal)Generator Settings40 mA, 40 kVDiffractometer Typed5000Diffractometer Number0Goniometer Radius [mm]217.50Incident Beam MonochromatorNoDiffracted Beam Monochromator(Graphite)SpinningYes Single Crystal X-Ray Diffraction (SXRD) All measurements were carried out using a Bruker Smart Apex diffractometer operating with Mo—Kα radiation. Unless otherwise specified the data were obtained in 60 ω-scan 10 s images collected in three separate settings of 2θ and φ. Differential Scanning Calorimetry (DSC) Approximately 5 mg of sample was weighed into an aluminium DSC pan and sealed with a pierced aluminium lid (non-hermetically). The sample pan was then loaded into a Seiko DSC6200 (equipped with a cooler), cooled, and held at 25° C. Once a stable heat-flow response was obtained, the sample and reference were then heated to about 250° C. at a scan rate of 10° C./min and the resulting heat flow response monitored. Prior to analysis, the instrument was temperature and heat-flow calibrated using an indium reference standard. Sample analysis was carried out by Muse measurement software where the temperatures of thermal events were quoted as the onset temperature, measured according to the manufacturer's specifications. Thermogravimetric Gravimetric/Differential Thermal Analysis (TG/DTA) Approximately 5 mg of sample was weighed into an aluminium pan and loaded into a simultaneous thermogravimetric/differential thermal analyser (DTA) and held at room temperature. The sample was then heated at a rate of 10° C./min from 25° C. to 300° C. during which time the change in sample weight was monitored along with any thermal events (DTA). Nitrogen was used as the purge gas, at a flow rate of 20 cm 3 /min. Prior to analysis the instrument was weight and temperature calibrated using a 100 mg reference weight and an indium reference standard, respectively. Dynamic Vapor Sorption (DVS) Approximately 10 mg of sample was placed into a wire-mesh vapor sorption balance pan and loaded into a DVS-1 dynamic vapor sorption balance supplied by Scientific and Medical Systems (SMS). The sample was then dried by maintaining a 0% humidity environment until no further weight change was recorded. The sample was then subjected to a ramping profile from 0-90% relative humidity (RH) at 10% increments, maintaining the sample at each step until a stable weight had been achieved (99.5% step completion). After completion of the sorption cycle, the sample was then dried using the same procedure. The weight change during the sorption/desorption cycles were then plotted, allowing for the hygroscopic nature of the sample to be determined. 1 H Nuclear Magnetic Resonance (NMR) 1 H NMR was performed on a Bruker AC200. An NMR of each sample was performed in d-H 2 O and each sample was prepared to about 5 mg concentration. The NMR spectra for L-ornithine benzoate and L-ornithine phenyl acetate are provided in FIGS. 21 and 22 , respectively. Solubility Approximations Approximately, 25 mg portions of the sample were placed in vials 5 volume increments of the appropriate solvent system were added. Between each addition, the mixture was checked for dissolution and if no dissolution was apparent, the mixture was warmed to 50° C., and checked again. The procedure was continued until dissolution was observed or when 100 volumes of solvent had been added. HPLC Solubility Determinations Slurries of each solvent were prepared and the samples shaken for about 48 hrs at 25° C. Each sample was then drawn through a filter, and the filtrate transferred to an HPLC vial for analysis. From the data the solubility of L-ornithine phenyl acetate for each solvent was determined. Temperature Cycling Experiments Using the information gathered from the solubility approximations, slurries of the sample were prepared in 24 selected solvent systems. The slurries were temperature cycled at 40° C. or 25° C. in 4 hour cycles for a period of 72 hours. The solids were visually checked for any obvious signs of degradation (i.e. color changes) and then, if not degraded, isolated by filtration. The solids were allowed to dry at ambient conditions for about 24 hours prior to analysis. Crash Cooling Experiments Crash cooling experiments were performed by placing saturated solutions of the sample, in the 24 selected solvent systems, in environments of 4° C. and −21° C. for about 48 hours. Any solid material was recovered and the solids were allowed to dry at ambient conditions for about 24 hours prior to analysis. Evaporation Experiments Evaporation experiments were conducted by allowing saturated solutions of the sample to evaporate freely at ambient conditions. The solid material was then recovered after the material had evaporated to dryness and analyzed. Anti-Solvent Addition Experiments Anti-solvent addition experiments were conducted by adding anti-solvent to saturated solutions of the sample. The addition was continued until there was no further precipitation and the samples adjusted to various temperature for 24 hours: elevated, ambient, 4° C. or −21°. The solid was then isolated and dried at ambient conditions for about 24 hours prior to analysis. Polarized Light Microscopy (PLM) The presence of crystallinity (birefringence) was determined using a Leica Leitz DMRB polarised optical microscope equipped with a high resolution Leica camera and image capture software (Firecam V.1.0). All images were recorded using a 10× objective, unless otherwise stated. Silver Analysis All silver analysis was carried out on an Agilent 7500ce ICP-MS. Intrinsic Dissolution Rates Approximately 100 mg of each form was compressed into discs by placing the material into a die (diameter 12 mm) and compressing the die under 5 tons of pressure in a hydraulic press for about 2 minutes. The dissolution instrument, Sotax AT7 conforms to EP2 and USP2 in which paddles were used to stir the media. Each form was tested under the following pH conditions; 1.0, 4.5 and 6.7, in the stationary disc mode (i.e. discs were added at time=0 seconds and allowed to sink to the bottom of the media). 1 cm 3 aliquots of media were extracted from the dissolution pots at times 10, 20, 30, 40, 50, 60, 70, 80 and 120 seconds and tested for API concentration by HPLC. Dissolution curves were plotted and from the first 6 or 7 points on the curves the intrinsic dissolution rate curves were calculated. All tests were carried out at 37° C. and a paddle speed of 150 rpm. HPLC-UV Instrument Details Instrument: Agilent 1200Column: Gemini C18, 5 μm, 150.0×4.6 mmColumn Temperature: 40° C.Mobile Phase A: Phosphate BufferMobile Phase B: AcetonitrileElution: Gradientλ: 210 nmInjection Volume: 10 μLFlow Rate: 1 mL/min Thin Layer Chromatography (TLC) A small spot of solution containing the sample was applied to a plate, about one centimeter from the base. The plate is then dipped into the TLC tank (sealed container) containing methanol:ethyl acetate (95:5) solvent mixture. The solvent moves up the plate by capillary action and meets the sample mixture, which is dissolved and is carried up the plate by the solvent mixture. The number of spots was noted and the R f values were calculated for each spot. Infrared (IR) Infrared spectroscopy was carried out on a Bruker ALPHA P spectrometer. Sufficient material was placed onto the centre of the plate of the spectrometer and the spectra were obtained using the following parameters: Resolution: 4 cm-1Background Scan Time: 16 scansSample Scan Time: 16 scansData Collection: 4000 to 400 cm-1Result Spectrum TransmittanceSoftware: OPUS version 6 Stabilities Studies: pH 1, 4, 7, 10 and 14 Environments Slurries (supersaturated solution: about 250 μl of pH solution and solid was added until dissolution was no longer observed and ca. 100 mg of solid was in the slurry) were prepared for each form in a variety of pH environments; 1, 4, 7, 10 and 13.2. The slurries were shaken constantly for a period of 14 days and measurements taken at 7 and 14 day time points. Appropriate buffers were prepared for each pH and are detailed further below. A buffer having a pH value of 1 was prepared by dissolving 372.75 mg of potassium chloride in 25 ml of deionized water to give a 0.2 M solution. Subsequently, 67 ml of 0.2 M hydrochloric acid was added (this was prepared from a 5 M solution; 10 ml was added to 40 ml of deionized water giving a 1 M solution which was diluted further; 20 ml was added to 80 ml of deionized water giving the required 0.2 M solution) to achieve the desired pH. A buffer having a pH value of 4 was prepared by dissolving 1.02 g of potassium hydrogen phthalate in 50 ml of deionized water to give a 0.1 M solution. A buffer having a pH value of 7 was prepared by dissolving 680.00 mg of potassium phosphate monobasic in 50 ml of deionized water to give a 0.1 M solution. Subsequently, 29.1 ml of 0.1 M sodium hydroxide was added (this was prepared from a 1 M solution; 5 ml was added to 45 ml of deionized water giving the required 0.1 M solution) to achieve the desired pH. A buffer having a pH value of 10 was prepared by dissolving 210.00 mg of sodium bicarbonate in 50 ml of deionized water to give a 0.05 M solution. Subsequently, 10.7 ml of 0.1 M sodium hydroxide was added (this was prepared from a 1 M solution; 5 ml was added to 45 ml of deionized water giving the required 0.1 M solution) to achieve the desired pH. A buffer having a pH value of pH 13.2 by dissolving 372.75 mg of potassium chloride in 25 ml of deionized water to give a 0.2 M solution. Subsequently, 66 ml of 0.2 M sodium hydroxide was added (this was prepared from a 1 M solution; 20 ml was added to 80 ml of deionized water giving the required 0.2 M solution) taking the pH to 13. 1M sodium hydroxide was then added drop wise to achieve the desired pH. Example 1 Precipitating Crystalline Forms Saturated solutions of L-ornithine phenyl acetate were subjected to temperature cycling, crash cooling, evaporation, or anti-solvent addition as described above. The precipitate was analyzed by PLM and XRPD to determine the crystalline form (if any). The results are summarized in TABLE 5. Six unique crystalline forms were identified from the precipitation studies, Forms I-VI. However, Forms IV and VI were obtained from solutions of acetic acid, and NMR results confirmed these forms to be L-ornithine acetate. Meanwhile, Tests 540-611 utilized samples of L-ornithine phenyl acetate originally isolated by the addition of ethanol anti-solvent. Many of these example produced Form I, which is an ethanol solvate, and therefore it is believed these samples originally included residual ethanol. Consequently, Form I may not be reproduced for certain conditions if the original sample does not include residual ethanol. TABLE 5Examples of Preparing Crystalline FormsCrystallizationTestMethodSolventResults1Temp. CyclingcyclohexanoneForm II2Controlled Cool (4° C.)cyclohexanoneNo Solid3Controlled Cool (−21° C.)cyclohexanoneForm V4EvaporationcyclohexanoneForm V5Anti-Solvent (IPA)cyclohexanoneNo SolidAddition ElevatedTemperature6Anti-Solvent (IPA)cyclohexanoneForm IIAddition AmbientTemperature7Anti-Solvent (IPA)cyclohexanoneForm IIAddition (4° C.)8Anti-Solvent (IPA)cyclohexanoneForm IIAddition (−21° C.)9Anti-Solvent (Ethanol)cyclohexanoneForm IIAddition AmbientTemperature10Anti-Solvent (Ethanol)cyclohexanoneForm IAddition (4° C.)11Anti-Solvent (Ethanol)cyclohexanoneForm IAddition (−21° C.)12Temp. Cyclingethanol/acetoneForm II(50:50)13Controlled Cool (4° C.)ethanol/acetoneNo Solid(50:50)14Controlled Cool (−21° C.)ethanol/acetoneForm III(50:50)15Evaporationethanol/acetoneForm II(50:50)16Anti-Solvent (IPA)ethanol/acetoneForm IIAddition Elevated(50:50)Temperature17Anti-Solvent (IPA)ethanol/acetoneForm IIAddition Ambient(50:50)Temperature18Anti-Solvent (IPA)ethanol/acetoneForm IIAddition (4° C.)(50:50)19Anti-Solvent (IPA)ethanol/acetoneForm IIAddition (−21° C.)(50:50)20Anti-Solvent (Ethanol)ethanol/acetoneForm IIAddition Ambient(50:50)Temperature21Anti-Solvent (Ethanol)ethanol/acetoneForm IAddition (4° C.)(50:50)22Anti-Solvent (Ethanol)ethanol/acetoneForm IAddition (−21° C.)(50:50)23Temp. Cyclingacetic acidForm IV24Controlled Cool (4° C.)acetic acidNo Solid25Controlled Cool (−21° C.)acetic acidNo Solid26Evaporationacetic acidForm II27Anti-Solvent (IPA)acetic acidForm VIAddition ElevatedTemperature28Anti-Solvent (IPA)acetic acidForm IVAddition AmbientTemperature29Anti-Solvent (IPA)acetic acidForm IVAddition (4° C.)30Anti-Solvent (IPA)acetic acidForm IVAddition (−21° C.)31Anti-Solvent (Ethanol)acetic acidForm IVAddition AmbientTemperature32Anti-Solvent (Ethanol)acetic acidForm IVAddition (4° C.)33Anti-Solvent (Ethanol)acetic acidForm IVAddition (−21° C.)34Temp. Cycling1-propanolForm II35Controlled Cool (4° C.)1-propanolForm II36Controlled Cool (−21° C.)1-propanolForm II37Evaporation1-propanolForm II38Anti-Solvent (IPA)1-propanolForm IIAddition ElevatedTemperature39Anti-Solvent (IPA)1-propanolForm IIAddition AmbientTemperature40Anti-Solvent (IPA)1-propanolForm IIAddition (4° C.)41Anti-Solvent (IPA)1-propanolForm IIAddition (−21° C.)42Anti-Solvent (Ethanol)1-propanolForm IIAddition AmbientTemperature43Anti-Solvent (Ethanol)1-propanolForm I/IIAddition (4° C.)44Anti-Solvent (Ethanol)1-propanolForm IAddition (−21° C.)45Temp. CyclingdimethylcarbonateForm II46Controlled Cool (4° C.)dimethylcarbonateNo Solid47Controlled Cool (−21° C.)dimethylcarbonateForm II48EvaporationdimethylcarbonateForm II49Anti-Solvent (IPA)dimethylcarbonateForm IIAddition ElevatedTemperature50Anti-Solvent (IPA)dimethylcarbonateForm IIAddition AmbientTemperature51Anti-Solvent (IPA)dimethylcarbonateForm IIAddition (4° C.)52Anti-Solvent (IPA)dimethylcarbonateForm IIAddition (−21° C.)53Anti-Solvent (Ethanol)dimethylcarbonateForm IIAddition AmbientTemperature54Anti-Solvent (Ethanol)dimethylcarbonateForm IAddition (4° C.)55Anti-Solvent (Ethanol)dimethylcarbonateForm IIAddition (−21° C.)56Temp. CyclingNMPForm II57Controlled Cool (4° C.)NMPForm II58Controlled Cool (−21° C.)NMPForm II59EvaporationNMPForm II60Anti-Solvent (IPA)NMPForm IIAddition ElevatedTemperature61Anti-Solvent (IPA)NMPForm IIAddition AmbientTemperature62Anti-Solvent (IPA)NMPForm IIAddition (4° C.)63Anti-Solvent (IPA)NMPForm IIAddition (−21° C.)64Anti-Solvent (Ethanol)NMPForm IIAddition AmbientTemperature65Anti-Solvent (Ethanol)NMPForm I/IIAddition (4° C.)66Anti-Solvent (Ethanol)NMPForm IIAddition (−21° C.)67Temp. CyclingEtOAc/cyclohexaneForm II(1:2)68Controlled Cool (4° C.)EtOAc/cyclohexaneNo Solid(1:2)69Controlled Cool (−21° C.)EtOAc/cyclohexaneNo Solid(1:2)70EvaporationetOAc/cyclohexaneForm II(1:2)71Anti-Solvent (IPA)etOAc/cyclohexaneForm IIAddition Elevated(1:2)Temperature72Anti-Solvent (IPA)etOAc/cyclohexaneForm IIAddition Ambient(1:2)Temperature73Anti-Solvent (IPA)etOAc/cyclohexaneForm IIAddition (4° C.)(1:2)74Anti-Solvent (IPA)etOAc/cyclohexaneForm IIAddition (−21° C.)(1:2)75Anti-Solvent (Ethanol)etOAc/cyclohexaneForm IIAddition Ambient(1:2)Temperature76Anti-Solvent (Ethanol)etOAc/cyclohexaneForm IAddition (4° C.)(1:2)77Anti-Solvent (Ethanol)etOAc/cyclohexaneForm I/IIAddition (−21° C.)(1:2)78Temp. CyclingetOAc/toluene (1:2)Form II79Controlled Cool (4° C.)etOAc/toluene (1:2)No Solid80Controlled Cool (−21° C.)etOAc/toluene (1:2)Form II81EvaporationetOAc/toluene (1:2)Form II82Anti-Solvent (IPA)etOAc/toluene (1:2)Form IIAddition ElevatedTemperature83Anti-Solvent (IPA)etOAc/toluene (1:2)Form IIAddition AmbientTemperature84Anti-Solvent (IPA)etOAc/toluene (1:2)Form IIAddition (4° C.)85Anti-Solvent (IPA)etOAc/toluene (1:2)Form IIAddition (−21° C.)86Anti-Solvent (Ethanol)etOAc/toluene (1:2)Form IIAddition AmbientTemperature87Anti-Solvent (Ethanol)etOAc/toluene (1:2)Form IAddition (4° C.)88Anti-Solvent (Ethanol)etOAc/toluene (1:2)Form IIAddition (−21° C.)89Temp. CyclingIPA/diisopropyl etherForm II(1:2)90Controlled Cool (4° C.)IPA/diisopropyl etherForm V(1:2)91Controlled Cool (−21° C.)IPA/diisopropyl etherForm II(1:2)92EvaporationIPA/diisopropyl etherForm II(1:2)93Anti-Solvent (IPA)IPA/diisopropyl etherForm IIAddition Elevated(1:2)Temperature94Anti-Solvent (IPA)IPA/diisopropyl etherForm IIAddition Ambient(1:2)Temperature95Anti-Solvent (IPA)IPA/diisopropyl etherForm IIAddition (4° C.)(1:2)96Anti-Solvent (IPA)IPA/diisopropyl etherForm IIAddition (−21° C.)(1:2)97Anti-Solvent (Ethanol)IPA/diisopropyl etherForm IIAddition Ambient(1:2)Temperature98Anti-Solvent (Ethanol)IPA/diisopropyl etherForm IAddition (4° C.)(1:2)99Anti-Solvent (Ethanol)IPA/diisopropyl etherForm I/IIAddition (−21° C.)(1:2)100Temp. CyclingDIPEForm II101Controlled Cool (4° C.)DIPENo Solid102Controlled Cool (−21° C.)DIPEForm V103EvaporationDIPEForm II104Anti-Solvent (IPA)DIPEForm IIAddition ElevatedTemperature105Anti-Solvent (IPA)DIPEForm IIAddition AmbientTemperature106Anti-Solvent (IPA)DIPEForm IIAddition (4° C.)107Anti-Solvent (IPA)DIPEForm IIAddition (−21° C.)108Anti-Solvent (Ethanol)DIPEForm IIAddition AmbientTemperature109Anti-Solvent (Ethanol)DIPEForm IAddition (4° C.)110Anti-Solvent (Ethanol)DIPEForm IIAddition (−21° C.)111Temp. Cyclingnitromethane/waterNo Solid(20%)112Controlled Cool (4° C.)nitromethane/waterNo Solid(20%)113Controlled Cool (−21° C.)nitromethane/waterNo Solid(20%)114Evaporationnitromethane/waterForm II(20%)115Anti-Solvent (IPA)nitromethane/waterNo SolidAddition Elevated(20%)Temperature116Anti-Solvent (IPA)nitromethane/waterForm IIAddition Ambient(20%)Temperature117Anti-Solvent (IPA)nitromethane/waterForm IIAddition (4° C.)(20%)118Anti-Solvent (IPA)nitromethane/waterForm IIAddition (−21° C.)(20%)119Anti-Solvent (Ethanol)nitromethane/waterForm IIAddition Ambient(20%)Temperature120Anti-Solvent (Ethanol)nitromethane/waterForm IAddition (4° C.)(20%)121Anti-Solvent (Ethanol)nitromethane/waterForm I/IIAddition (−21° C.)(20%)122Temp. Cyclingacetone/water (20%)No Solid123Controlled Cool (4° C.)acetone/water (20%)Form II124Controlled Cool (−21° C.)acetone/water (20%)Form II125Evaporationacetone/water (20%)Form II126Anti-Solvent (IPA)acetone/water (20%)Form IIAddition ElevatedTemperature127Anti-Solvent (IPA)acetone/water (20%)Form IIAddition AmbientTemperature128Anti-Solvent (IPA)acetone/water (20%)Form IIAddition (4° C.)129Anti-Solvent (IPA)acetone/water (20%)Form IIAddition (−21° C.)130Anti-Solvent (Ethanol)acetone/water (20%)Form IIAddition AmbientTemperature131Anti-Solvent (Ethanol)acetone/water (20%)Form IAddition (4° C.)132Anti-Solvent (Ethanol)acetone/water (20%)Form IIAddition (−21° C.)133Temp. Cycling1,4 dioxane/waterForm II(20%)134Controlled Cool (4° C.)1,4 dioxane/waterForm II(20%)135Controlled Cool (−21° C.)1,4 dioxane/waterNo Solid(20%)136Evaporation1,4 dioxane/waterForm II(20%)137Anti-Solvent (IPA)1,4 dioxane/waterForm IIAddition Elevated(20%)Temperature138Anti-Solvent (IPA)1,4 dioxane/waterForm IIAddition Ambient(20%)Temperature139Anti-Solvent (IPA)1,4 dioxane/waterForm IIAddition (4° C.)(20%)140Anti-Solvent (IPA)1,4 dioxane/waterForm IIAddition (−21° C.)(20%)141Anti-Solvent (Ethanol)1,4 dioxane/waterForm IIAddition Ambient(20%)Temperature142Anti-Solvent (Ethanol)1,4 dioxane/waterForm IAddition (4° C.)(20%)143Anti-Solvent (Ethanol)1,4 dioxane/waterForm IIAddition (−21° C.)(20%)144Temp. Cyclingdiethyl etherForm II145Controlled Cool (4° C.)diethyl etherNo Solid146Controlled Cool (−21° C.)diethyl etherNo Solid147Evaporationdiethyl etherForm II148Anti-Solvent (IPA)diethyl etherForm IIAddition ElevatedTemperature149Anti-Solvent (IPA)diethyl etherForm IIAddition AmbientTemperature150Anti-Solvent (IPA)diethyl etherForm IIAddition (4° C.)151Anti-Solvent (IPA)diethyl etherForm IIAddition (−21° C.)152Anti-Solvent (Ethanol)diethyl etherForm IIAddition AmbientTemperature153Anti-Solvent (Ethanol)diethyl etherForm IAddition (4° C.)154Anti-Solvent (Ethanol)diethyl etherForm I/IIAddition (−21° C.)155Temp. Cyclingethylene glycolForm II156Controlled Cool (4° C.)ethylene glycolNo Solid157Controlled Cool (−21° C.)ethylene glycolNo Solid158Evaporationethylene glycolNo Solid159Anti-Solvent (IPA)ethylene glycolForm IIAddition ElevatedTemperature160Anti-Solvent (IPA)ethylene glycolForm IIAddition AmbientTemperature161Anti-Solvent (IPA)ethylene glycolForm IIAddition (4° C.)162Anti-Solvent (IPA)ethylene glycolForm IIAddition (−21° C.)163Anti-Solvent (Ethanol)ethylene glycolForm IIAddition AmbientTemperature164Anti-Solvent (Ethanol)ethylene glycolForm IIAddition (4° C.)165Anti-Solvent (Ethanol)ethylene glycolForm IIAddition (−21° C.)166Temp. CyclingmeOAc/water (20%)No Solid167Controlled Cool (4° C.)meOAc/water (20%)No Solid168Controlled Cool (−21° C.)meOAc/water (20%)No Solid169EvaporationmeOAc/water (20%)Form II170Anti-Solvent (IPA)meOAc/water (20%)Form IIAddition ElevatedTemperature171Anti-Solvent (IPA)meOAc/water (20%)Form IIAddition AmbientTemperature172Anti-Solvent (IPA)meOAc/water (20%)Form IIAddition (4° C.)173Anti-Solvent (IPA)meOAc/water (20%)Form IIAddition (−21° C.)174Anti-Solvent (Ethanol)meOAc/water (20%)Form IIAddition AmbientTemperature175Anti-Solvent (Ethanol)meOAc/water (20%)Form I/IIAddition (4° C.)176Anti-Solvent (Ethanol)meOAc/water (20%)Form IIAddition (−21° C.)177Temp. CyclingmeOH/acetoneForm II(50:50)178Controlled Cool (4° C.)meOH/acetoneNo Solid(50:50)179Controlled Cool (−21° C.)meOH/acetoneNo Solid(50:50)180EvaporationmeOH/acetoneForm II(50:50)181Anti-Solvent (IPA)meOH/acetoneForm IIAddition Elevated(50:50)Temperature182Anti-Solvent (IPA)meOH/acetoneForm IIAddition Ambient(50:50)Temperature183Anti-Solvent (IPA)meOH/acetoneForm IIAddition (4° C.)(50:50)184Anti-Solvent (IPA)meOH/acetoneForm IIAddition (−21° C.)(50:50)185Anti-Solvent (Ethanol)meOH/acetoneForm IIAddition Ambient(50:50)Temperature186Anti-Solvent (Ethanol)meOH/acetoneForm IAddition (4° C.)(50:50)187Anti-Solvent (Ethanol)meOH/acetoneForm I/IIAddition (−21° C.)(50:50)188Temp. CyclingDMFForm II189Controlled Cool (4° C.)DMFForm II190Controlled Cool (−21° C.)DMFForm II191EvaporationDMFForm II192Anti-Solvent (IPA)DMFForm IIAddition ElevatedTemperature193Anti-Solvent (IPA)DMFForm IIAddition AmbientTemperature194Anti-Solvent (IPA)DMFForm IIAddition (4° C.)195Anti-Solvent (IPA)DMFForm IIAddition (−21° C.)196Anti-Solvent (Ethanol)DMFForm IIAddition AmbientTemperature197Anti-Solvent (Ethanol)DMFForm I/IIAddition (4° C.)198Anti-Solvent (Ethanol)DMFForm IIAddition (−21° C.)199Temp. Cycling2-butanolForm II200Controlled Cool (4° C.)2-butanolNo Solid201Controlled Cool (−21° C.)2-butanolNo Solid202Evaporation2-butanolForm II203Anti-Solvent (IPA)2-butanolForm IIIAddition ElevatedTemperature204Anti-Solvent (IPA)2-butanolForm IIAddition AmbientTemperature205Anti-Solvent (IPA)2-butanolForm IIAddition (4° C.)206Anti-Solvent (IPA)2-butanolForm IIAddition (−21° C.)207Anti-Solvent (Ethanol)2-butanolForm IIAddition AmbientTemperature208Anti-Solvent (Ethanol)2-butanolForm I/IIAddition (4° C.)209Anti-Solvent (Ethanol)2-butanolForm I/IIAddition (−21° C.)210Temp. CyclingcumeneForm II211Controlled Cool (4° C.)cumeneNo Solid212Controlled Cool (−21° C.)cumeneNo Solid213EvaporationcumeneForm II214Anti-Solvent (IPA)cumeneForm IIAddition ElevatedTemperature215Anti-Solvent (IPA)cumeneForm IIAddition AmbientTemperature216Anti-Solvent (IPA)cumeneForm IIAddition (4° C.)217Anti-Solvent (IPA)cumeneForm IIAddition (−21° C.)218Anti-Solvent (Ethanol)cumeneForm IIAddition AmbientTemperature219Anti-Solvent (Ethanol)cumeneForm IIAddition (4° C.)220Anti-Solvent (Ethanol)cumeneForm I/IIAddition (−21° C.)221Temp. Cyclingethyl formateForm II222Controlled Cool (4° C.)ethyl formateNo Solid223Controlled Cool (−21° C.)ethyl formateForm II224Evaporationethyl formateForm II225Anti-Solvent (IPA)ethyl formateForm IIAddition ElevatedTemperature226Anti-Solvent (IPA)ethyl formateForm IIAddition AmbientTemperature227Anti-Solvent (IPA)ethyl formateForm IIAddition (4° C.)228Anti-Solvent (IPA)ethyl formateForm IIAddition (−21° C.)229Anti-Solvent (Ethanol)ethyl formateForm IIAddition AmbientTemperature230Anti-Solvent (Ethanol)ethyl formateForm IAddition (4° C.)231Anti-Solvent (Ethanol)ethyl formateForm I/IIAddition (−21° C.)232Temp. Cyclingisobutyl acetateForm II233Controlled Cool (4° C.)isobutyl acetateNo Solid234Controlled Cool (−21° C.)isobutyl acetateForm II235Evaporationisobutyl acetateNo Solid236Anti-Solvent (IPA)isobutyl acetateForm IIAddition ElevatedTemperature237Anti-Solvent (IPA)isobutyl acetateForm IIAddition AmbientTemperature238Anti-Solvent (IPA)isobutyl acetateForm IIAddition (4° C.)239Anti-Solvent (IPA)isobutyl acetateForm IIIAddition (−21° C.)240Anti-Solvent (Ethanol)isobutyl acetateForm IIAddition AmbientTemperature241Anti-Solvent (Ethanol)isobutyl acetateForm IIAddition (4° C.)242Anti-Solvent (Ethanol)isobutyl acetateForm I/IIAddition (−21° C.)243Temp. Cycling3-methyl-1-butanolForm II244Controlled Cool (4° C.)3-methyl-1-butanolNo Solid245Controlled Cool (−21° C.)3-methyl-1-butanolNo Solid246Evaporation3-methyl-1-butanolForm II247Anti-Solvent (IPA)3-methyl-1-butanolForm IIAddition ElevatedTemperature248Anti-Solvent (IPA)3-methyl-1-butanolForm IIAddition AmbientTemperature249Anti-Solvent (IPA)3-methyl-1-butanolForm IIAddition (4° C.)250Anti-Solvent (IPA)3-methyl-1-butanolForm IIAddition (−21° C.)251Anti-Solvent (Ethanol)3-methyl-1-butanolForm IIAddition AmbientTemperature252Anti-Solvent (Ethanol)3-methyl-1-butanolForm I/IIAddition (4° C.)253Anti-Solvent (Ethanol)3-methyl-1-butanolForm I/IIAddition (−21° C.)254Temp. CyclinganisoleForm II255Controlled Cool (4° C.)anisoleNo Solid256Controlled Cool (−21° C.)anisoleForm II257EvaporationanisoleForm II258Anti-Solvent (IPA)anisoleForm IIAddition ElevatedTemperature259Anti-Solvent (IPA)anisoleForm IIAddition AmbientTemperature260Anti-Solvent (IPA)anisoleForm IIAddition (4° C.)261Anti-Solvent (IPA)anisoleForm II/IVAddition (−21° C.)262Anti-Solvent (Ethanol)anisoleForm IIAddition AmbientTemperature263Anti-Solvent (Ethanol)anisoleForm IIAddition (4° C.)264Anti-Solvent (Ethanol)anisoleForm IAddition (−21° C.)265Temp. CyclingIPA/isopropyl acetateForm II(1:2)266Controlled Cool (4° C.)IPA/isopropyl acetateNo Solid(1:2)267Controlled Cool (−21° C.)IPA/isopropyl acetateNo Solid(1:2)268EvaporationIPA/isopropyl acetateForm II(1:2)269Anti-Solvent (IPA)IPA/isopropyl acetateForm IIAddition Elevated(1:2)Temperature270Anti-Solvent (IPA)IPA/isopropyl acetateForm IIAddition Ambient(1:2)Temperature271Anti-Solvent (IPA)IPA/isopropyl acetateForm IIAddition (4° C.)(1:2)272Anti-Solvent (IPA)IPA/isopropyl acetateForm IIAddition (−21° C.)(1:2)273Anti-Solvent (Ethanol)IPA/isopropyl acetateForm IIAddition Ambient(1:2)Temperature274Anti-Solvent (Ethanol)IPA/isopropyl acetateForm IIAddition (4° C.)(1:2)275Anti-Solvent (Ethanol)IPA/isopropyl acetateForm IAddition (−21° C.)(1:2)276Temp. CyclingEtOH: 1% H 2 0Form II277Controlled Cool (4° C.)EtOH: 1% H 2 0No Solid278Controlled Cool (−21° C.)EtOH: 1% H 2 0No Solid279EvaporationEtOH: 1% H 2 0No Solid280Anti-Solvent (IPA)EtOH: 1% H 2 0No SolidAddition ElevatedTemperature281Anti-Solvent (IPA)EtOH: 1% H 2 0No SolidAddition AmbientTemperature282Anti-Solvent (IPA)EtOH: 1% H 2 0No SolidAddition (4° C.)283Anti-Solvent (IPA)EtOH: 1% H 2 0No SolidAddition (−21° C.)284Anti-Solvent (Ethanol)EtOH: 1% H 2 0No SolidAddition AmbientTemperature285Anti-Solvent (Ethanol)EtOH: 1% H 2 0No SolidAddition (4° C.)286Anti-Solvent (Ethanol)EtOH: 1% H 2 0No SolidAddition (−21° C.)287Temp. CyclingEtOH: 3% H 2 0Form II288Controlled Cool (4° C.)EtOH: 3% H 2 0No Solid289Controlled Cool (−21° C.)EtOH: 3% H 2 0No Solid290EvaporationEtOH: 3% H 2 0No Solid291Anti-Solvent (IPA)EtOH: 3% H 2 0No SolidAddition ElevatedTemperature292Anti-Solvent (IPA)EtOH: 3% H 2 0No SolidAddition AmbientTemperature293Anti-Solvent (IPA)EtOH: 3% H 2 0No SolidAddition (4° C.)294Anti-Solvent (IPA)EtOH: 3% H 2 0No SolidAddition (−21° C.)295Anti-Solvent (Ethanol)EtOH: 3% H 2 0No SolidAddition AmbientTemperature296Anti-Solvent (Ethanol)EtOH: 3% H 2 0No SolidAddition (4° C.)297Anti-Solvent (Ethanol)EtOH: 3% H 2 0No SolidAddition (−21° C.)298Temp. CyclingEtOH: 5% H 2 0Form II299Controlled Cool (4° C.)EtOH: 5% H 2 0No Solid300Controlled Cool (−21° C.)EtOH: 5% H 2 0No Solid301EvaporationEtOH: 5% H 2 0Form II302Anti-Solvent (IPA)EtOH: 5% H 2 0No SolidAddition ElevatedTemperature303Anti-Solvent (IPA)EtOH: 5% H 2 0Form IIAddition AmbientTemperature304Anti-Solvent (IPA)EtOH: 5% H 2 0No SolidAddition (4° C.)305Anti-Solvent (IPA)EtOH: 5% H 2 0No SolidAddition (−21° C.)306Anti-Solvent (Ethanol)EtOH: 5% H 2 0No SolidAddition AmbientTemperature307Anti-Solvent (Ethanol)EtOH: 5% H 2 0No SolidAddition (4° C.)308Anti-Solvent (Ethanol)EtOH: 5% H 2 0No SolidAddition (−21° C.)309Temp. CyclingIPA: 1% H 2 0Form II310Controlled Cool (4° C.)IPA: 1% H 2 0No Solid311Controlled Cool (−21° C.)IPA: 1% H 2 0No Solid312EvaporationIPA: 1% H 2 0No Solid313Anti-Solvent (IPA)IPA: 1% H 2 0No SolidAddition ElevatedTemperature314Anti-Solvent (IPA)IPA: 1% H 2 0No SolidAddition AmbientTemperature315Anti-Solvent (IPA)IPA: 1% H 2 0No SolidAddition (4° C.)316Anti-Solvent (IPA)IPA: 1% H 2 0No SolidAddition (−21° C.)317Anti-Solvent (Ethanol)IPA: 1% H 2 0No SolidAddition AmbientTemperature318Anti-Solvent (Ethanol)IPA: 1% H 2 0No SolidAddition (4° C.)319Anti-Solvent (Ethanol)IPA: 1% H 2 0No SolidAddition (−21° C.)320Temp. CyclingIPA: 3% H 2 0Form II321Controlled Cool (4° C.)IPA: 3% H 2 0No Solid322Controlled Cool (−21° C.)IPA: 3% H 2 0No Solid323EvaporationIPA: 3% H 2 0No Solid324Anti-Solvent (IPA)IPA: 3% H 2 0No SolidAddition ElevatedTemperature325Anti-Solvent (IPA)IPA: 3% H 2 0No SolidAddition AmbientTemperature326Anti-Solvent (IPA)IPA: 3% H 2 0No SolidAddition (4° C.)327Anti-Solvent (IPA)IPA: 3% H 2 0No SolidAddition (−21° C.)328Anti-Solvent (Ethanol)IPA: 3% H 2 0No SolidAddition AmbientTemperature329Anti-Solvent (Ethanol)IPA: 3% H 2 0No SolidAddition (4° C.)330Anti-Solvent (Ethanol)IPA: 3% H 2 0No SolidAddition (−21° C.)331Temp. CyclingIPA: 5% H 2 0Form II332Controlled Cool (4° C.)IPA: 5% H 2 0No Solid333Controlled Cool (−21° C.)IPA: 5% H 2 0No Solid334EvaporationIPA: 5% H 2 0Form II335Anti-Solvent (IPA)IPA: 5% H 2 0No SolidAddition ElevatedTemperature336Anti-Solvent (IPA)IPA: 5% H 2 0No SolidAddition AmbientTemperature337Anti-Solvent (IPA)IPA: 5% H 2 0No SolidAddition (4° C.)338Anti-Solvent (IPA)IPA: 5% H 2 0No SolidAddition (−21° C.)339Anti-Solvent (Ethanol)IPA: 5% H 2 0No SolidAddition AmbientTemperature340Anti-Solvent (Ethanol)IPA: 5% H 2 0No SolidAddition (4° C.)341Anti-Solvent (Ethanol)IPA: 5% H 2 0No SolidAddition (−21° C.)342Temp. CyclingACN: 1% H 2 0Form II343Controlled Cool (4° C.)ACN: 1% H 2 0No Solid344Controlled Cool (−21° C.)ACN: 1% H 2 0No Solid345EvaporationACN: 1% H 2 0Form II346Anti-Solvent (IPA)ACN: 1% H 2 0No SolidAddition ElevatedTemperature347Anti-Solvent (IPA)ACN: 1% H 2 0No SolidAddition AmbientTemperature348Anti-Solvent (IPA)ACN: 1% H 2 0No SolidAddition (4° C.)349Anti-Solvent (IPA)ACN: 1% H 2 0No SolidAddition (−21° C.)350Anti-Solvent (Ethanol)ACN: 1% H 2 0No SolidAddition AmbientTemperature351Anti-Solvent (Ethanol)ACN: 1% H 2 0No SolidAddition (4° C.)352Anti-Solvent (Ethanol)ACN: 1% H 2 0No SolidAddition (−21° C.)353Temp. CyclingACN: 6% H 2 0Form II354Controlled Cool (4° C.)ACN: 6% H 2 0No Solid355Controlled Cool (−21° C.)ACN: 6% H 2 0No Solid356EvaporationACN: 6% H 2 0Form II357Anti-Solvent (IPA)ACN: 6% H 2 0No SolidAddition ElevatedTemperature358Anti-Solvent (IPA)ACN: 6% H 2 0No SolidAddition AmbientTemperature359Anti-Solvent (IPA)ACN: 6% H 2 0No SolidAddition (4° C.)360Anti-Solvent (IPA)ACN: 6% H 2 0No SolidAddition (−21° C.)361Anti-Solvent (Ethanol)ACN: 6% H 2 0No SolidAddition AmbientTemperature362Anti-Solvent (Ethanol)ACN: 6% H 2 0No SolidAddition (4° C.)363Anti-Solvent (Ethanol)ACN: 6% H 2 0No SolidAddition (−21° C.)364Temp. CyclingACN: 12% H 2 0No Solid365Controlled Cool (4° C.)ACN: 12% H 2 0No Solid366Controlled Cool (−21° C.)ACN: 12% H 2 0No Solid367EvaporationACN: 12% H 2 0Form II368Anti-Solvent (IPA)ACN: 12% H 2 0No SolidAddition ElevatedTemperature369Anti-Solvent (IPA)ACN: 12% H 2 0Form IIAddition AmbientTemperature370Anti-Solvent (IPA)ACN: 12% H 2 0No SolidAddition (4° C.)371Anti-Solvent (IPA)ACN: 12% H 2 0Form IIAddition (−21° C.)372Anti-Solvent (Ethanol)ACN: 12% H 2 0No SolidAddition AmbientTemperature373Anti-Solvent (Ethanol)ACN: 12% H 2 0No SolidAddition (4° C.)374Anti-Solvent (Ethanol)ACN: 12% H 2 0No SolidAddition (−21° C.)375Temp. CyclingDMF: 5% H 2 0Form II376Controlled Cool (4° C.)DMF: 5% H 2 0No Solid377Controlled Cool (−21° C.)DMF: 5% H 2 0No Solid378EvaporationDMF: 5% H 2 0No Solid379Anti-Solvent (IPA)DMF: 5% H 2 0No SolidAddition ElevatedTemperature380Anti-Solvent (IPA)DMF: 5% H 2 0No SolidAddition AmbientTemperature381Anti-Solvent (IPA)DMF: 5% H 2 0No SolidAddition (4° C.)382Anti-Solvent (IPA)DMF: 5% H 2 0No SolidAddition (−21° C.)383Anti-Solvent (Ethanol)DMF: 5% H 2 0No SolidAddition AmbientTemperature384Anti-Solvent (Ethanol)DMF: 5% H 2 0No SolidAddition (4° C.)385Anti-Solvent (Ethanol)DMF: 5% H 2 0No SolidAddition (−21° C.)386Temp. CyclingDMF: 15% H 2 0Form II387Controlled Cool (4° C.)DMF: 15% H 2 0No Solid388Controlled Cool (−21° C.)DMF: 15% H 2 0No Solid389EvaporationDMF: 15% H 2 0No Solid390Anti-Solvent (IPA)DMF: 15% H 2 0No SolidAddition ElevatedTemperature391Anti-Solvent (IPA)DMF: 15% H 2 0No SolidAddition AmbientTemperature392Anti-Solvent (IPA)DMF: 15% H 2 0No SolidAddition (4° C.)393Anti-Solvent (IPA)DMF: 15% H 2 0No SolidAddition (−21° C.)394Anti-Solvent (Ethanol)DMF: 15% H 2 0No SolidAddition AmbientTemperature395Anti-Solvent (Ethanol)DMF: 15% H 2 0No SolidAddition (4° C.)396Anti-Solvent (Ethanol)DMF: 15% H 2 0No SolidAddition (−21° C.)397Temp. CyclingDMF: 30% H 2 0Form II398Controlled Cool (4° C.)DMF: 30% H 2 0Form II399Controlled Cool (−21° C.)DMF: 30% H 2 0Form II400EvaporationDMF: 30% H 2 0Form II401Anti-Solvent (IPA)DMF: 30% H 2 0Form IIAddition ElevatedTemperature402Anti-Solvent (IPA)DMF: 30% H 2 0Form IIAddition AmbientTemperature403Anti-Solvent (IPA)DMF: 30% H 2 0Form IIAddition (4° C.)404Anti-Solvent (IPA)DMF: 30% H 2 0Form IIAddition (−21° C.)405Anti-Solvent (Ethanol)DMF: 30% H 2 0Form IIAddition AmbientTemperature406Anti-Solvent (Ethanol)DMF: 30% H 2 0No SolidAddition (4° C.)407Anti-Solvent (Ethanol)DMF: 30% H 2 0Form IIAddition (−21° C.)408Temp. Cycling1,4-dioxane: 1% H 2 0Form II409Controlled Cool (4° C.)1,4-dioxane: 1% H 2 0No Solid410Controlled Cool (−21° C.)1,4-dioxane: 1% H 2 0No Solid411Evaporation1,4-dioxane: 1% H 2 0No Solid412Anti-Solvent (IPA)1,4-dioxane: 1% H 2 0No SolidAddition ElevatedTemperature413Anti-Solvent (IPA)1,4-dioxane: 1% H 2 0No SolidAddition AmbientTemperature414Anti-Solvent (IPA)1,4-dioxane: 1% H 2 0No SolidAddition (4° C.)415Anti-Solvent (IPA)1,4-dioxane: 1% H 2 0No SolidAddition (−21° C.)416Anti-Solvent (Ethanol)1,4-dioxane: 1% H 2 0No SolidAddition AmbientTemperature417Anti-Solvent (Ethanol)1,4-dioxane: 1% H 2 0No SolidAddition (4° C.)418Anti-Solvent (Ethanol)1,4-dioxane: 1% H 2 0No SolidAddition (−21° C.)419Temp. Cycling1,4-dioxane: 3% H 2 0Form II420Controlled Cool (4° C.)1,4-dioxane: 3% H 2 0No Solid421Controlled Cool (−21° C.)1,4-dioxane: 3% H 2 0No Solid422Evaporation1,4-dioxane: 3% H 2 0Form II423Anti-Solvent (IPA)1,4-dioxane: 3% H 2 0No SolidAddition ElevatedTemperature424Anti-Solvent (IPA)1,4-dioxane: 3% H 2 0No SolidAddition AmbientTemperature425Anti-Solvent (IPA)1,4-dioxane: 3% H 2 0No SolidAddition (4° C.)426Anti-Solvent (IPA)1,4-dioxane: 3% H 2 0No SolidAddition (−21° C.)427Anti-Solvent (Ethanol)1,4-dioxane: 3% H 2 0No SolidAddition AmbientTemperature428Anti-Solvent (Ethanol)1,4-dioxane: 3% H 2 0No SolidAddition (4° C.)429Anti-Solvent (Ethanol)1,4-dioxane: 3% H 2 0No SolidAddition (−21° C.)430Temp. Cycling1,4-dioxane: 10% H 2 0Form II431Controlled Cool (4° C.)1,4-dioxane: 10% H 2 0No Solid432Controlled Cool (−21° C.)1,4-dioxane: 10% H 2 0No Solid433Evaporation1,4-dioxane: 10% H 2 0Form II434Anti-Solvent (IPA)1,4-dioxane: 10% H 2 0No SolidAddition ElevatedTemperature435Anti-Solvent (IPA)1,4-dioxane: 10% H 2 0No SolidAddition AmbientTemperature436Anti-Solvent (IPA)1,4-dioxane: 10% H 2 0No SolidAddition (4° C.)437Anti-Solvent (IPA)1,4-dioxane: 10% H 2 0No SolidAddition (−21° C.)438Anti-Solvent (Ethanol)1,4-dioxane: 10% H 2 0No SolidAddition AmbientTemperature439Anti-Solvent (Ethanol)1,4-dioxane: 10% H 2 0No SolidAddition (4° C.)440Anti-Solvent (Ethanol)1,4-dioxane: 10% H 2 0No SolidAddition (−21° C.)441Temp. CyclingMeOH: 5% H 2 0Form II442Controlled Cool (4° C.)MeOH: 5% H 2 0No Solid443Controlled Cool (−21° C.)MeOH: 5% H 2 0No Solid444EvaporationMeOH: 5% H 2 0Form II445Anti-Solvent (IPA)MeOH: 5% H 2 0Form IIAddition ElevatedTemperature446Anti-Solvent (IPA)MeOH: 5% H 2 0Form IIAddition AmbientTemperature447Anti-Solvent (IPA)MeOH: 5% H 2 0Form IIAddition (4° C.)448Anti-Solvent (IPA)MeOH: 5% H 2 0Form IIAddition (−21° C.)449Anti-Solvent (Ethanol)MeOH: 5% H 2 0No SolidAddition AmbientTemperature450Anti-Solvent (Ethanol)MeOH: 5% H 2 0Form IIAddition (4° C.)451Anti-Solvent (Ethanol)MeOH: 5% H 2 0Form IIAddition (−21° C.)452Temp. CyclingMeOH: 20% H 2 0No Solid453Controlled Cool (4° C.)MeOH: 20% H 2 0Form II454Controlled Cool (−21° C.)MeOH: 20% H 2 0Form II455EvaporationMeOH: 20% H 2 0Form II456Anti-Solvent (IPA)MeOH: 20% H 2 0Form IIAddition ElevatedTemperature457Anti-Solvent (IPA)MeOH: 20% H 2 0Form IIAddition AmbientTemperature458Anti-Solvent (IPA)MeOH: 20% H 2 0Form IIAddition (4° C.)459Anti-Solvent (IPA)MeOH: 20% H 2 0Form IIAddition (−21° C.)460Anti-Solvent (Ethanol)MeOH: 20% H 2 0Form IIAddition AmbientTemperature461Anti-Solvent (Ethanol)MeOH: 20% H 2 0Form IIAddition (4° C.)462Anti-Solvent (Ethanol)MeOH: 20% H 2 0Form I/IIAddition (−21° C.)463Temp. CyclingMeOH: 50% H 2 0Form II464Controlled Cool (4° C.)MeOH: 50% H 2 0Form II465Controlled Cool (−21° C.)MeOH: 50% H 2 0Form II466EvaporationMeOH: 50% H 2 0No Solid467Anti-Solvent (IPA)MeOH: 50% H 2 0Form IIAddition ElevatedTemperature468Anti-Solvent (IPA)MeOH: 50% H 2 0No SolidAddition AmbientTemperature469Anti-Solvent (IPA)MeOH: 50% H 2 0Form IIAddition (4° C.)470Anti-Solvent (IPA)MeOH: 50% H 2 0No SolidAddition (−21° C.)471Anti-Solvent (Ethanol)MeOH: 50% H 2 0Form IIAddition AmbientTemperature472Anti-Solvent (Ethanol)MeOH: 50% H 2 0Form IAddition (4° C.)473Anti-Solvent (Ethanol)MeOH: 50% H 2 0Form I/IIAddition (−21° C.)474Temp. CyclingTHF: 1% H 2 0Form II475Controlled Cool (4° C.)THF: 1% H 2 0No Solid476Controlled Cool (−21° C.)THF: 1% H 2 0No Solid477EvaporationTHF: 1% H 2 0Form II478Anti-Solvent (IPA)THF: 1% H 2 0No SolidAddition ElevatedTemperature479Anti-Solvent (IPA)THF: 1% H 2 0No SolidAddition AmbientTemperature480Anti-Solvent (IPA)THF: 1% H 2 0No SolidAddition (4° C.)481Anti-Solvent (IPA)THF: 1% H 2 0No SolidAddition (−21° C.)482Anti-Solvent (Ethanol)THF: 1% H 2 0No SolidAddition AmbientTemperature483Anti-Solvent (Ethanol)THF: 1% H 2 0No SolidAddition (4° C.)484Anti-Solvent (Ethanol)THF: 1% H 2 0No SolidAddition (−21° C.)485Temp. CyclingTHF: 3% H 2 0Form II486Controlled Cool (4° C.)THF: 3% H 2 0No Solid487Controlled Cool (−21° C.)THF: 3% H 2 0No Solid488EvaporationTHF: 3% H 2 0No Solid489Anti-Solvent (IPA)THF: 3% H 2 0No SolidAddition ElevatedTemperature490Anti-Solvent (IPA)THF: 3% H 2 0Form IIAddition AmbientTemperature491Anti-Solvent (IPA)THF: 3% H 2 0No SolidAddition (4° C.)492Anti-Solvent (IPA)THF: 3% H 2 0No SolidAddition (−21° C.)493Anti-Solvent (Ethanol)THF: 3% H 2 0No SolidAddition AmbientTemperature494Anti-Solvent (Ethanol)THF: 3% H 2 0No SolidAddition (4° C.)495Anti-Solvent (Ethanol)THF: 3% H 2 0No SolidAddition (−21° C.)496Temp. CyclingTHF: 5% H 2 0No Solid497Controlled Cool (4° C.)THF: 5% H 2 0No Solid498Controlled Cool (−21° C.)THF: 5% H 2 0No Solid499EvaporationTHF: 5% H 2 0Form II500Anti-Solvent (IPA)THF: 5% H 2 0No SolidAddition ElevatedTemperature501Anti-Solvent (IPA)THF: 5% H 2 0No SolidAddition AmbientTemperature502Anti-Solvent (IPA)THF: 5% H 2 0Form IIAddition (4° C.)503Anti-Solvent (IPA)THF: 5% H 2 0No SolidAddition (−21° C.)504Anti-Solvent (Ethanol)THF: 5% H 2 0No SolidAddition AmbientTemperature505Anti-Solvent (Ethanol)THF: 5% H 2 0No SolidAddition (4° C.)506Anti-Solvent (Ethanol)THF: 5% H 2 0No SolidAddition (−21° C.)507Temp. Cyclingbutan-1-ol: 1% H 2 0Form II508Controlled Cool (4° C.)butan-1-ol: 1% H 2 0No Solid509Controlled Cool (−21° C.)butan-1-ol: 1% H 2 0No Solid510Evaporationbutan-1-ol: 1% H 2 0Form II511Anti-Solvent (IPA)butan-1-ol: 1% H 2 0No SolidAddition ElevatedTemperature512Anti-Solvent (IPA)butan-1-ol: 1% H 2 0No SolidAddition AmbientTemperature513Anti-Solvent (IPA)butan-1-ol: 1% H 2 0No SolidAddition (4° C.)514Anti-Solvent (IPA)butan-1-ol: 1% H 2 0No SolidAddition (−21° C.)515Anti-Solvent (Ethanol)butan-1-ol: 1% H 2 0No SolidAddition AmbientTemperature516Anti-Solvent (Ethanol)butan-1-ol: 1% H 2 0No SolidAddition (4° C.)517Anti-Solvent (Ethanol)butan-1-ol: 1% H 2 0No SolidAddition (−21° C.)518Temp. Cyclingbutan-1-ol: 3% H 2 0Form II519Controlled Cool (4° C.)butan-1-ol: 3% H 2 0No Solid520Controlled Cool (−21° C.)butan-1-ol: 3% H 2 0No Solid521Evaporationbutan-1-ol: 3% H 2 0Form II522Anti-Solvent (IPA)butan-1-ol: 3% H 2 0No SolidAddition ElevatedTemperature523Anti-Solvent (IPA)butan-1-ol: 3% H 2 0No SolidAddition AmbientTemperature524Anti-Solvent (IPA)butan-1-ol: 3% H 2 0No SolidAddition (4° C.)525Anti-Solvent (IPA)butan-1-ol: 3% H 2 0No SolidAddition (−21° C.)526Anti-Solvent (Ethanol)butan-1-ol: 3% H 2 0No SolidAddition AmbientTemperature527Anti-Solvent (Ethanol)butan-1-ol: 3% H 2 0No SolidAddition (4° C.)528Anti-Solvent (Ethanol)butan-1-ol: 3% H 2 0No SolidAddition (−21° C.)529Temp. Cyclingbutan-1-ol: 5% H 2 0Form II530Controlled Cool (4° C.)butan-1-ol: 5% H 2 0No Solid531Controlled Cool (−21° C.)butan-1-ol: 5% H 2 0No Solid532Evaporationbutan-1-ol: 5% H 2 0Form II533Anti-Solvent (IPA)butan-1-ol: 5% H 2 0No SolidAddition ElevatedTemperature534Anti-Solvent (IPA)butan-1-ol: 5% H 2 0Form IIAddition AmbientTemperature535Anti-Solvent (IPA)butan-1-ol: 5% H 2 0No SolidAddition (4° C.)536Anti-Solvent (IPA)butan-1-ol: 5% H 2 0No SolidAddition (−21° C.)537Anti-Solvent (Ethanol)butan-1-ol: 5% H 2 0No SolidAddition AmbientTemperature538Anti-Solvent (Ethanol)butan-1-ol: 5% H 2 0No SolidAddition (4° C.)539Anti-Solvent (Ethanol)butan-1-ol: 5% H 2 0No SolidAddition (−21° C.)540Temp. Cycling1,4-dioxaneForm I541Evaporation1,4-dioxaneForm I/II542Anti-Solvent Addition1,4-dioxaneNo Solid543Temp. Cycling1-butanolForm I544Evaporation1-butanolForm I/II545Anti-Solvent (Hexane)1-butanolForm IIIAddition (4° C.)546Temp. CyclingethanolForm I547EvaporationethanolForm II548Anti-Solvent (Hexane)ethanolForm IAddition (4° C.)549Temp. CyclingacetoneForm I550EvaporationacetoneForm II551Anti-Solvent (Hexane)acetoneForm IIIAddition (4° C.)552Temp. CyclingbenzonitrileForm I553EvaporationbenzonitrileForm II554Anti-Solvent (Hexane)benzonitrileForm IIAddition (4° C.)555Temp. CyclingcyclohexaneForm I556EvaporationcyclohexaneForm II557Anti-Solvent (Hexane)cyclohexaneNo SolidAddition (4° C.)558Temp. CyclingDCMForm I559EvaporationDCMForm II560Anti-Solvent (Hexane)DCMForm IIIAddition (4° C.)561Temp. CyclingDMSOForm I562EvaporationDMSOForm II/II563Anti-Solvent (Hexane)DMSONo Solid/NoAddition (4° C.)Solid564Temp. CyclingEtOAcForm I565EvaporationEtOAcForm II566Anti-Solvent (Hexane)EtOAcForm IIIAddition (4° C.)567Temp. CyclingHeptaneForm I568EvaporationHeptaneForm I/II569Anti-Solvent (Hexane)HeptaneNo Solid/NoAddition (4° C.)Solid570Temp. CyclingIPAForm I571EvaporationIPAForm I/II572Anti-Solvent (Hexane)IPANo SolidAddition (4° C.)573Temp. CyclingIPA: Water (1%)Form I574EvaporationIPA: Water (1%)Form II575Anti-Solvent (Hexane)IPA: Water (1%)No Solid/NoAddition (4° C.)Solid576Temp. CyclingMeCNForm I577EvaporationMeCNForm II578Anti-Solvent (Hexane)MeCNForm I/IIIAddition (4° C.)579Temp. CyclingMeCN: Water (1%)Form I580EvaporationMeCN: Water (1%)Form I/II581Anti-Solvent (Hexane)MeCN: Water (1%)No SolidAddition (4° C.)582Temp. CyclingMEKForm I583EvaporationMEKForm I/II584Anti-Solvent (Hexane)MEKForm IIIAddition (4° C.)585Temp. CyclingMeOAcForm I586EvaporationMeOAcForm II587Anti-Solvent (Hexane)MeOAcForm IIIAddition (4° C.)588Temp. CyclingMeOHForm I589EvaporationMeOHForm I/II590Anti-Solvent (Hexane)MeOHForm IIIAddition (4° C.)591Temp. CyclingMIBKForm I592EvaporationMIBKForm II593Anti-Solvent (Hexane)MIBKNo SolidAddition (4° C.)594Temp. CyclingNitromethaneForm I595EvaporationNitromethaneForm II596Anti-Solvent (Hexane)NitromethaneForm IAddition (4° C.)597Temp. CyclingTBMEForm I598EvaporationTBMEForm II599Anti-Solvent (Hexane)TBMEForm IAddition (4° C.)600Temp. CyclingTHFForm I601EvaporationTHFForm II602Anti-Solvent (Hexane)THFForm I/IIIAddition (4° C.)603Temp. CyclingTHF: water (1%)Form I604EvaporationTHF: water (1%)Form I/II605Anti-Solvent (Hexane)THF: water (1%)No SolidAddition (4° C.)606Temp. CyclingtolueneForm I607EvaporationtolueneForm II608Anti-Solvent (Hexane)tolueneForm IIIAddition (4° C.)609Temp. CyclingwaterNo Solid610EvaporationwaterForm I/II611Anti-Solvent (Hexane)waterForm IIIAddition (4° C.) Example 2 Intrinsic Dissolution Studies The intrinsic dissolution rates for Forms I, II, and III were measured at pH conditions of 1.0, 4.5 and 6.7. The results are reproduced below in TABLE 6. In each case, complete dissolution was achieved in less than 3 minutes. Surprisingly, a pH dependence was observed for Form II; with the intrinsic dissolution rate increasing with the pH. In contrast, Forms I and III appear to dissolve at rates independent of pH. TABLE 6Calculated Intrinsic Dissolution Rates (mg/cm 2 /s)1.04.56.7Form I0.410.440.37Form II0.260.340.62Form III0.490.440.45 Example 3 Solubility Studies The solubility of L-ornithine phenyl acetate was approximated according to methods disclosed above. 24 solvents systems were tested: 1,4 dioxane, 1-butanol, ethanol, acetone, benzonitrile, cyclohexane, DCM, DMSO, EtOAc, Heptane, IPA, IPA (1% H 2 O), MeCN, MeCn (1% H 2 O), MEK, MeOAc, methanol, MIBK, Nitromethane, THF, THF (1% H 2 O), Toluene and water. L-ornithine phenyl acetate exhibited a solubility in water, whereas L-ornithine phenyl acetate was substantially insoluble in the remaining solvent systems. Slurries of L-ornithine phenyl acetate in water were also prepared and the slurry was filtered. The filtrate concentration was analyzed by HPLC, and the results show the solubility of L-ornithine phenyl acetate to be about 1.072 mg/mL. HPLC determinations of solubility were also completed for five solvents: ethanol, acetone, methanol, DMSO and IPA. These results are summarized in TABLE 7. TABLE 7HPLC Solubility DeterminationsSolubilitySolvent(mg/mL)Peak AreaCommentsEtOH<0.0033N/ASmall peakAcetone00API content beyond the lower limit ofquantification (LLOQ)MeOH0.00331906.75Resolved peakDMSO>0.0033N/AShoulder on DMSO peakIPA00API content beyond the LLOQ These results indicate that both acetone and IPA are suitable as anti-solvents for precipitating L-ornithine phenyl acetate. In contrast, solvents with measurable solubility are less favorable for precipitating crystalline forms of L-ornithine phenyl acetate. Finally, the solubility of L-ornithine phenyl acetate was determined in various mixtures of IPA and water using HPLC. The results are shown in TABLE 8. TABLE 8HPLC Solubility Determinations (IPA/Water)% IPAPeak AreaSolubility (mg/mL)10000902950.00548026340.04557083400.1433 Example 4 Small-Scale Batch Process to Produce L-Ornithine Phenyl Acetate About 8.4 g (0.049 moles) of L-ornithine HCl was dissolved in 42 mL H 2 O and, separately, about 11.4 g of silver benzoate was dissolved in 57 mL DMSO. Subsequently, the silver benzoate solution was added to the L-ornithine HCl solution. Combining the two mixtures resulted in an immediate, exothermic precipitation of a creamy white solid (AgCl). The solid was removed by vacuum filtration and retaining the filtrate (L-ornithine benzoate in solution). 200 mL of IPA was added to the filtrate and the mixture was cooled to 4° C. A crystalline solid precipitated after about 3 hours (L-ornithine benzoate) which was isolated by vacuum filtration. Yield: 60% 7.6 g (0.03 moles) of the L-ornithine benzoate was dissolved in 38 mL H 2 O and about 4.4 g of sodium phenyl acetate was dissolved 22 mL H2O. Subsequently, the sodium phenyl acetate solution was added to the L-ornithine benzoate solution and left to stir for about 10 minutes About 240 mL of IPA (8:2 IPA:H 2 O) was added and the solution stirred for 30 minutes before cooling to 4° C. A crystalline solid precipitated after about 3 hrs at 4° C. (L-ornithine phenyl acetate). The precipitate was isolated by vacuum filtration and washed with 48-144 mL of IPA. Yield: 57% Example 5 Large-Scale Batch Process to Produce L-Ornithine Phenyl Acetate Two separate batch of L-ornithine phenyl acetate were prepared as follows: About 75 Kg of L-Ornithine monohydrochloride was dissolved in 227 kg of water. To the resulting solution was added 102 Kg of silver benzoate dissolved in 266 kg of DMSO at room temperature within 2 hours. Initially, a strong exothermy was observed and the silver chloride precipitated. The receiver containing the solution was then washed with 14 Kg of DMSO that was added to the reaction mass. In order to remove the silver chloride formed, the reaction mass was filtered over a lens filter prepared with 10 kg of Celite and a GAF filter of 1 mm. After filtration, the filter was washed with an additional 75 kg of water. The reaction mass was then heated at 35±2° C. and 80 kg of sodium phenyl acetate was added. At this point the reaction mass was stirred at 35±2° C. for at least 30 minutes. In order to precipitate the final API, 353 kg of isopropyl alcohol was added to the reaction mass. The reaction mass was then cooled to 0±3° C. within 6 hours, stirred for 1 hour and then the product isolated in a centrifuge. About 86 kg of finished wet produce was obtained. The product was then dried at 40±5° C. for about 6.5 to 8 hours to provide about 75 kg of L-ornithine phenyl acetate. Yield: 63.25. TABLE 9 summarizes measurements relating to the final product. TABLE 9Analytical Results for Large-scale Batch ProcessTestBatch 1Batch 2Purity98.80%98.74%Benzoate0.17%0.14%Silver28 ppm157 ppmChloride0.006%0.005%Sodium7 ppm26 ppmTotal Impurities0.17%0.14%Physical FormForm IIForm II Example 6 Reducing Silver Content in L-Ornithine Phenyl Acetate Batch 2 from Example 5 exhibited high amounts of silver (157 ppm), and therefore procedures were tested for reducing the silver content. Nine trials were completed; each generally including dissolving about 20 g of L-ornithine phenyl acetate from Batch 2 into 1.9 parts water, and then subsequently adding 10.8 parts IPA. A crystalline form was isolated at 0° C. by filtration. For four trials, 8.0 mg or 80 mg of heavy metal scavengers SMOPEX 102 or SMOPEX 112 were added to the aqueous solution and stirred for 2 hours. The scavengers failed to reduce the silver content below 126 ppm. Meanwhile, another trial applied the general conditions disclosed above and reduced the silver content to 179 ppm. In still another trial, the L-ornithine phenyl acetate was slurried in a solution of IPA, rather than crystallized; however this trial also failed to reduce the silver content below 144 ppm. The last three trials included adding diluted HCl to the solution to precipitate remaining amount of silver as AgCl. The precipitate was then removed by filtration before The three trials included adding: (1) 1.0 g of 0.33% HCl at 20° C.; (2) 1.0 g of 0.33% HCl at 30° C.; and (3) 0.1 g of 3.3% HCl at 20° C. The three trials reduced the silver content to 30 ppm, 42 ppm, and 33 ppm, respectively, and each trial yielding greater than 90% L-ornithine phenyl acetate. Accordingly, the addition of HCl was effective in reducing the amount of residual silver. Example 6 Process for Preparing L-Ornithine Phenyl Acetate without an Intermediate Salt As a general procedure, L-ornithine hydrochloride was suspended in a solvent. After that the reaction mass was heated and a base, sodium methoxide, was added. NaCl formed and was removed from the system by filtration. The reaction mass was cooled and a molar equivalent of phenyl acetic acid was added to the reaction mass in order to form L-ornithine phenyl acetate. The final product was isolated, washed and dried. A summary of the trial for this process is provided in TABLE 10. TABLE 10Process TrialsTrialBaseEq. of BaseSolvent1NaOMe 21% in MeOH1.0 eq.MeOH2NaOMe 21% in MeOH0.95 eq.IPA3NaOMe 21% in EtOH1.0 eq.EtOH4NaOMe 21% in MeOH1.0 eq.MeOH5NaOMe 21% in MeOH1.0 eq.MeOH w/ IPAfor precipitation6NaOMe 21% in MeOH1.0 eq.Acetonitrile7NaOMe 21% in MeOH1.0 eq.Water/IPA8NaOMe 21% in MeOH1.0 eq.Water/IPA9NaOMe 21% in MeOH1.0 eq.n-butanol The resulting L-ornithine phenyl acetate was found to exhibit high amounts of chloride (at least about 1% by weight), and presumably include similar amounts of sodium. The yields were about 50% for Trials 2, 4, and 5. Example 7 Thermal Stability Studies of Forms I, II, and III Samples of Forms I, II and III were stored at increased temperatures and designated conditions as outlined in TABLE 11. The vacuum applied 600 psi to achieve the reduced pressure. The final compositions were tested by XRPD, NMR, IR and HPLC to determine any changes to the material. Most notably, Form III does not transition to Form II under vacuum at 120° C., but rather exhibits greater chemical degradation compared to Forms I and II under these conditions. Meanwhile, Form III converts to Form II and exhibits substantial chemical degradation at 120° C. without a vacuum. Form I converted to Form II in all the trials, but most interestingly, Form I exhibits substantial chemical degradation at 120° C. without a vacuum. Thus, the conversion from Form I does not exhibit the same chemical stability as Form II, which is surprising considering the material readily converts to Form II. Form II was stable and did not chemically degrade in all of the trials. Thus, Form II is the most stable. Meanwhile, Form III is more stable than Form I, but both forms exhibit substantial chemical degradation at 120° C. without a vacuum. TABLE 11Thermal Stability TrialsInitialTem-TrialFormperatureConditionPeriodResults1Form I80° C.no vacuum7 daysForm II,no degradation2Form I80° C.vacuum7 daysForm II,no degradation3Form I80° C.no vacuum14 daysForm II,no degradation4Form I80° C.vacuum14 daysForm II,no degradation5Form II80° C.no vacuum7 daysForm II,no degradation6Form II80° C.vacuum7 daysForm II,no degradation7Form II80° C.no vacuum14 daysForm II,no degradation8Form II80° C.vacuum14 daysForm II,no degradation5Form III80° C.no vacuum7 daysForm III,no degradation5Form III80° C.no vacuum14 daysForm III,no degradation6Form I120° C.no vacuum7 daysForm II (>96% API)7Form I120° C.vacuum7 daysForm II(>99.9% API)8Form I120° C.no vacuum14 daysForm II (37% API)9Form I120° C.vacuum14 daysForm II (>96% API)8Form II120° C.no vacuum7 daysForm II(98.6% API)9Form II120° C.vacuum7 daysForm II(98.7% API)10Form II120° C.no vacuum14 daysForm II (>95% API)11Form II120° C.vacuum14 daysForm II (>95% API)10Form III120° C.no vacuum7 daysForm II (<30% API)11Form III120° C.vacuum7 daysForm III(>95% API)12Form III120° C.no vacuum14 daysForm II (<30% API)14Form III120° C.vacuum14 daysForm III(88.8% API) HPLC results for the trials exhibiting chemical degradation (e.g., Trial 10 from TABLE 11) are summarized in TABLE 12. Each degraded material exhibits common peaks at relative retention times (RRT) of 1.9, 2.2, 2.4, and 2.7, which suggests a common degradation pathway for different forms. TABLE 12HPLC Results for Degraded SamplesMain Peak RetentionDegradation/ImpuirtyTime (min)Peak(s)HPLCTimepointRetentionRetentionIDSample IDForm TestedStability Test(day)Time (min)% Peak AreaTime (min)% Peak Area39W00045/45/3III120° C. ambient72.85735.7866.7636.103pressure7.58245.16142W00045/45/6III120° C. under vacuum72.78788.8857.5989.389(ca. 600 psi)51W00045/45/1I120° C. ambient143.49937.8266.7663.948pressure7.56942.5259.7073.62853W00045/45/3III120° C. ambient143.47630.3946.7635.975pressure7.58356.45956W00045/45/6III120° C. under vacuum143.40087.3897.55511.500(ca. 600 psi) Example 8 Oxygen Stability Studies of Forms I, II, and III Samples of Forms I, II and III were stored in 100% oxygen environments for 7 or 14 days and analyzed by NMR and IR. The results establish that Forms I and II show no signs of degradation after 14 days. Only IR results were completed for Form III at 7 days, and these results confirm there was no significant degradation. TLC results for all samples indicated a single spot with similar R f values. Example 9 UV Stability Studies of Forms I, II, and III Samples of Forms I, II and III were exposed to ultraviolet (UV) radiation for 7 or 14 days. A CAMAG universal UV Lampe applied radiation to the samples with setting of 254 m μ. NMR and IR results show no degradation of Forms I and II after 14 days. Similarly, Form III exhibits no degradation after 7 days as determined by NMR and IR. TLC results for all samples indicated a single spot with similar R f values. Example 10 pH Stability Studies of Forms I, II, and III A slurry of Forms I, II and III were formed with water and the pH value adjusted to either 1.0, 4.0, 7.0, 10.0, and 13.2. The slurries were stored for 7 or 14 days, and subsequently the solids were removed by filtration. Form I converted to Form II in all of the samples. NMR and IR results show Forms I and II did not degrade after 14 days in the varied pHs, and similarly HPLC results show about 98% purity or more for these samples. Form III also exhibited no degradation after 7 days according to NMR and IR results. HPLC tests show about 95% purity or more; however IR results show Form III converted to Form II over the 7-day test. TLC results for all samples indicated a single spot with similar R f values. Example 11 Compression Studies of Forms I, II, and III Samples of Forms I, II and III were subjected to 3 tons of force using a Moore Hydraulic Press for about 90 minutes. The resultant tablet's mass, diameter and thickness were measured to determine the density. The tablets were also analyzed by NMR and IR. Form I transitioned to a composition of Form II with a density of 1.197 kg/m 3 . Form II did not exhibit a transition and had a final density of 1.001 kg/m 3 . Finally, Form III did not exhibit a transition and had a final density of 1.078 kg/m 3 . Example 12 Process for Producing L-Ornithine Phenyl Acetate Via an Acetate Intermediate Dissolve 25 mg of L-ornithine HCl 5 vols of H 2 O, and then add excess acetic acid (about 5 vols) to form a slurry. Subject the slurry to temperature cycling between 25° and 40° C. every 4 hours for about 3 days. Add 1 equivalent of phenylacetic acid (with respect to L-ornithine) and stir for about 4-6 hrs (possibly heat). Use IPA as an anti-solvent, add enough to obtain a ratio of 70:30 (IPA:H 2 O). 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molecules as determined by thermogravimetric analysis."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein said crystalline form is characterized by differential scanning calorimetry as comprising an endotherm at about 35° C."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 5, further comprising a melting point at about 203° C."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein said crystalline form exhibits a single crystal X-ray crystallographic analysis with crystal parameters approximately equal to the following:\n
unit cell dimensions: a=5.3652(4) Å, b=7.7136(6) Å, c=20.9602(18) Å, α=90°, β=94.986(6)°, γ=90°;\n
Crystal System: Monoclinic; and\n
Space Group: P21."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the said crystalline form is represented by the formula [C5H13N2O2][C8H7O2]EtOH.H2O."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A method of treating or ameliorating hyperammonemia in a subject by orally administering a therapeutically effective amount of the crystalline form of claim 2."],"number":9,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}