{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"096-018-839-180-368","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"096-018-839-180-368"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8909,"type":"PATENT","title":"Cornell Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":11969,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8223,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Cornell Univ\", \" Univ Cornell\", \" Cornell Res* Found*\", \"Corne* Univ* Tech* Enter* Comm*\".
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Total patent: 10677
Search applicants and owners= \"Cornell Univ\", \" Univ Cornell\", \" Cornell Res* Found*\", \"Corne* Univ* Tech* Enter* Comm*\".
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Total patent: 10677
wherein\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the compound of formula (I) is a compound of formula (IA)\na dashed bond indicates that a bond can be present or absent;\nwhen a double bond is present between Y1 and Y2, Y1 is N or CR, Y2 is C, and Ar1 is present; when a single bond is present between Y1 and Y2, Y1 is CR2, Y2 is O or S, and Ar1 is absent, and each independently selected R is H or (C1-C6)alkyl;\nY3 is N;\nR1 is alkyl, alkoxyalkyl, or arylalkyl, wherein any alkyl, alkoxyalkyl, or arylalkyl, can be mono- or independently multi-substituted with halo or (C1-C6)alkoxy, provided that when a double bond is present between the oxygen atom and the ring comprising Y3, R1 is absent and Ar3 is present, and when a single bond is present between the oxygen atom and the ring, R1 is present, a double bond between Y3 and the carbon atom bearing the oxygen atom is present, and Ar3 is absent;\nAr1 is phenyl substituted with 1-3 J1 groups; J1 is halo or (C1-C6)alkoxy;\nAr2 is phenyl substituted with 1-3 J2 groups; J2 is a group of formula —N(R)C(O)—R2 and R2 is alkyl, aryl, or arylamino, wherein any alkyl, aryl, or arylamino is substituted with 0-2 halo, nitro, or (C1-C6)alkoxy groups, with the proviso that if R2 is alkyl, the alkyl is substituted with 1-2 halo, nitro, or (C1-C6)alkoxy groups;\nAr3 is phenyl substituted with 1-3 J3 groups; J3 is halo or (C1-C6)alkoxy, but is absent if there is double bond present between the carbon atom adjacent to Y3 and Y3;\nor any salt, hydrate, tautomer, or stereoisomer thereof.\n
wherein R1, Ar1, and Ar2 are as defined for formula (I),\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the compound is selected from the group consisting of:\n\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the MALT1 is disposed within a living animal."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4 wherein the living animal is a human afflicted with cancer."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the compound is:\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method of modulating MALT1, comprising contacting MALT1 with an effective amount or concentration of a compound of formula (IB)\n
wherein\n\nAr2 is phenyl substituted with 1-3 J2 groups; J2 is a group of formula —N(R)C(O)—R2 and R2 is alkyl, aryl, or arylamino, wherein any alkyl, aryl, or arylamino is substituted with 0-2 halo, nitro, or (C1-C6)alkoxy groups; with the proviso that if R2 is alkyl, the alkyl is substituted with 1-2 halo, nitro, or (C1-C6)alkoxy groups;\nAr3 is phenyl substituted with 1-3 J3 groups; J3 is halo or (C1-C6)alkoxy,\n
and R is H or (C1-C6)alkyl;\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A method of alleviating the symptoms of lymphoma comprising administering to a patient in need thereof, an effective amount or concentration of a compound of formula (I):\n
wherein\n"],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8, wherein the compound of formula (I) is a compound of formula (IA)\na dashed bond indicates that a bond can be present or absent;\nwhen a double bond is present between Y1 and Y2, Y1 is N or CR, Y2 is C, and Ar1 is present; when a single bond is present between Y1 and Y2, Y1 is CR2, Y2 is O or S, and Ar1 is absent, and each independently selected R is H or (C1-C6)alkyl;\nY3 is N;\nR1 is alkyl, alkoxyalkyl, or arylalkyl, wherein any alkyl, alkoxyalkyl, or arylalkyl, can be mono- or independently multi-substituted with halo or (C1-C6)alkoxy, provided that when a double bond is present between the oxygen atom and the ring comprising Y3, R1 is absent and Ar3 is present, and when a single bond is present between the oxygen atom and the ring, R1 is present, a double bond between Y3 and the carbon atom bearing the oxygen atom is present, and Ar3 is absent;\nAr1 is phenyl substituted with 1-3 J1 groups; J1 is halo or (C1-C6)alkoxy;\nAr2 is phenyl substituted with 1-3 J2 groups; J2 is a group of formula —N(R)C(O)—R2 and R2 is alkyl, aryl, or arylamino, wherein any alkyl, aryl, or arylamino is substituted with 0-2 halo, nitro, or (C1-C6)alkoxy groups, with the proviso that if R2 is alkyl, the alkyl is substituted with 1-2 halo, nitro, or (C1-C6)alkoxy groups;\nAr3 is phenyl substituted with 1-3 J3 groups; J3 is halo or (C1-C6)alkoxy, but is absent if there is double bond present between the carbon atom adjacent to Y3 and Y3;\nor any salt, hydrate, tautomer, or stereoisomer thereof.\n
wherein R1, Ar1, and Ar2 are as defined for formula (I),\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 wherein the compound is selected from the group consisting of:\n\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 8 wherein the lymphoma is a diffuse large B-cell lymphoma."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["A method of alleviating the symptoms of lymphoma comprising administering to a patient in need thereof, an effective amount or concentration of a compound of formula (IB):\n
wherein\n\nAr2 is phenyl substituted with 1-3 J2 groups; J2 is a group of formula —N(R)C(O)—R2 and R2 is alkyl, aryl, or arylamino, wherein any alkyl, aryl, or arylamino is substituted with 0-2 halo, nitro, or (C1-C6)alkoxy groups; with the proviso that if R2 is alkyl, the alkyl is substituted with 1-2 halo, nitro, or (C1-C6)alkoxy groups;\nAr3 is phenyl substituted with 1-3 J3 groups; J3 is halo or (C1-C6)alkoxy,\n
and R is H or (C1-C6)alkyl;\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 12, wherein the compound is:\n
or any salt, hydrate, tautomer, or stereoisomer thereof."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["A method of identifying a small molecule modulator of MALT1, comprising contacting a recombinant form of MALT1 (340-789) fused with a leucine zipper dimerization motif (LZ-MALT1) and a candidate modulator compound, using the MALT1 substrate peptide LRSR linked to the fluorogen AMC (7-amino-4-methylcoumarin), such that cleavage of the Ac-LRSR-AMC substrate by MALT1 results in release of AMC and a fluorescent signal, wherein a decrease in the cleavage of the Ac-LRSR-AMC substrate by the recombinant form of MALT1 in the presence of the candidate modulator indicates that the candidate modulator is a small molecule modulator of MALT1."],"number":14,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}