{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"093-748-522-082-810","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"093-748-522-082-810","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8635,"type":"PATENT","title":"MIT Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":30193,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8198,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Note: over 20k
Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Note: over 20k
or a salt thereof;\n
wherein:\n"],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\nA is acyclic, substituted or unsubstituted, branched or unbranched aliphatic; or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;\nV is C═O;\nR1 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORA; —SRA; or —NHRA; wherein each occurrence of RA is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nR2 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORB; —SRB; or —NHRB; wherein each occurrence of RB is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nR3 is hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORC; —C(═O)RC; —CO2RC; —CN; —SCN; —SRC; —SORC; —SO2RC; —NO2; —N3; —N(RC)2; —NHC(═O)RC; —NRCC(═O)N(RC)2; —OC(═O)ORC; —OC(═O)RC; —OC(═O)N(RC)2; —NRCC(═O)ORC; or —C(RC)3; wherein each occurrence of RC is independently a hydrogen; a protecting group; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted, heteroaryl; or —CH2CH2C(═O)R1;\nR4 is hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORD; —C(═O)RD; —CO2RD; —CN; —SCN; —SRD; —SORD; —SO2RD; —NO2; —N3; —N(RD)2; —NHC(═O)RD; —NRCC(═O)N(RD)2; —OC(═O)ORD; —OC(═O)RD; —OC(═O)N(RD)2; —NRCC(═O)ORD; or —C(RD)3; wherein each occurrence of RD is independently a hydrogen; a protecting group; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; or —CH2CH2C(═O)R1;\nwherein at least one of R3, R4, or R7 is —CH2CH2C(═O)R1;\neach occurrence of R5 is independently selected from the group consisting of hydrogen and C1-C6 alkyl;\neach occurrence of R6 is independently selected from the group consisting of hydrogen and C1-C6 alkyl;\nR7 is hydrogen; halogen; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORG; —C(═O)RG; —CO2RG; —CN; —SCN; —SRG; —SORG; —SO2RG; —NO2; —N3; —N(RG)2; —NHC(═O)RG; —NRGC(═O)N(RG)2; —OC(═O)ORG; —OC(═O)RG; —OC(═O)N(RG)2; —NRGC(═O)ORG; or —CH2CH2C(═O)R1; wherein each occurrence of RG is independently a hydrogen; a protecting group; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted, branched or unbranched acyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; an acyl moiety; alkoxy; aryloxy; alkylthio; arylthio; amino, alkylamino, dialkylamino, heteroaryloxy; or heteroarylthio moiety;\nn is an integer between 1 and 10, inclusive; and\nwherein each instance of substituted refers to the replacement of one, two, three, or more of the hydrogen atoms of an aliphatic, heteroaliphatic, aryl, or heteroaryl group with one, two, three, or more substituents independently selected from the group consisting of aliphatic; heteroaliphatic; aryl; heteroaryl; arylalkyl; heteroarylalkyl; alkoxy; aryloxy; heteroalkoxy; heteroaryloxy; alkylthio; arylthio; heteroalkylthio; heteroarylthio; —F; —Cl; —Br; —I; —OH; —NO2; —CN; —CF3; —CH2CF3; —CHCl2; —CH2OH; —CH2CH2OH; —CH2NH2; —CH2SO2CH3; —C(O)Rx; —CO2(Rx); —CO(O)Rx; —OCO2Rx; —OCON(Rx)2; —N(Rx)2; —N(Rx)2; —S(O)2Rx; and —NRx(CO)Rx, wherein each occurrence of Rx independently is selected from the group consisting of aliphatic, heteroaliphatic, aryl, heteroaryl, arylalkyl, and heteroarylalkyl\nand salts thereof.\n
is selected from the group consisting of:"],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["A compound of formula:\n
or a salt thereof;\n
wherein:\n"],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein each occurrence of R7 is independently selected from the group consisting of:"],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein each occurrence of R7 is independently selected from the group consisting of:"],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3 of the formula:"],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A compound of the formula:\neach occurrence of x is an integer between 1 and 10, inclusive;\ny is an integer between 1 and 10, inclusive;\neach occurrence of R7 is independently hydrogen or —CH2CH2C(═O)R1;\nwherein at least one of R7 is —CH2CH2C(═O)R1;\neach occurrence of R1 is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORA; —SRA; or —NHRA; wherein each occurrence of RA is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nwherein each instance of substituted refers to the replacement of one, two, three, or more of the hydrogen atoms of an aliphatic, heteroaliphatic, aryl, or heteroaryl group with one, two, three, or more substituents independently selected from the group consisting of aliphatic; heteroaliphatic; aryl; heteroaryl; arylalkyl; heteroarylalkyl; alkoxy; aryloxy; heteroalkoxy; heteroaryloxy; alkylthio; arylthio; heteroalkylthio; heteroarylthio; —F; —Cl; —Br; —I; —OH; —NO2; —CN; —CF3; —CH2CF3; —CHCl2; —CH2OH; —CH2CH2OH; —CH2NH2; —CH2SO2CH3; —C(O)Rx; —CO2(Rx); —OC(O)Rx; —OCO2Rx; —OCON(Rx)2; —N(Rx)2; —S(O)2Rx; and —NRx(CO)Rx, wherein each occurrence of Rx independently is selected from the group consisting of aliphatic, heteroaliphatic, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.\n
or a salt thereof;\n
wherein:\n"],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7, wherein\nA is acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;\nV is C═O;\nR1 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —SRA; and —NHRA; wherein each occurrence of RA is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nR2 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —SRB; or —NHRB; wherein each occurrence of RB is independently a cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nR3 is hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORC; —C(═O)RC; —CO2RC; —CN; —SCN; —SRC; —SORC; —NO2; —N3; —N(RC)2; —NHC(═O)RC; —NRCC(═O)N(RC)2; —OC(═O)ORC; —OC(═O)Rc; —OC(═O)N(RC)2; —NRCC(═O)ORC; or —C(RC)3; wherein each occurrence of RC is independently a hydrogen; a protecting group; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nR4 is hydrogen; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; —ORD; —C(═O)RD; —CO2RD; —CN; —SCN; —SRD; —SORD; —SO2RD; —NO2; —N3; —N(RD)2; —NHC(═O)RD; —NRCC(═O)N(RD)2; —OC(═O)ORD; —OC(═O)RD; —OC(═O)N(RD)2; —NRCC(═O)ORD; or —C(RD)3; wherein each occurrence of RD is independently a hydrogen; a protecting group; halogen; cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic; cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl;\nprovided that at least one of R3 and R4 is a substituted aliphatic;\nwherein each instance of substituted refers to the replacement of one, two, three, or more of the hydrogen atoms of an aliphatic, heteroaliphatic, aryl, or heteroaryl group with one, two, three, or more substituents independently selected from the group consisting of aliphatic; heteroaliphatic; aryl; heteroaryl; arylalkyl; heteroarylalkyl; alkoxy; aryloxy; heteroalkoxy; heteroaryloxy; alkylthio; arylthio; heteroalkylthio; heteroarylthio; —F; —Cl; —Br; —I; —OH; —NO2; —CN; —CF3; —CH2CF3; —CHCl2; —CH2OH; —CH2CH2OH; —CH2NH2; —CH2SO2CH3; —C(O)Rx; —CO2(Rx); —OC(O)Rx; —OCO2Rx; —OCON(Rx)2; —N(Rx)2; —S(O)2Rx; and —NRx(CO)Rx, wherein each occurrence of Rx independently is selected from the group consisting of aliphatic, heteroaliphatic, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.\n
is selected from the group consisting of:"],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\n
are independently selected from the group consisting of:"],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein\n
are independently selected from the group consisting of:"],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein each occurrence of R7 is independently selected from the group consisting of hydrogen,"],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein each occurrence of R7 is independently selected from the group consisting of hydrogen,"],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3 selected from the group consisting of:\n\n\n\n
wherein n is 8, 9, 10, 11, 12, 13, 14, or 15."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A composition comprising one or more compounds of claim 13."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound according to claim 3 selected from the group consisting of:\n\n\n\n
wherein n is 8, 9, 10, 11, 12, 13, 14, or 15."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["A composition comprising one or more compounds of claim 15."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13 selected from the group consisting of:"],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A composition comprising one or more compounds of claim 17."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 14 or 16 further comprising an agent to be delivered."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 19, wherein the agent is a polynucleotide, a protein, a peptide, or a small molecule."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 20, wherein the agent is a polynucleotide."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 21, wherein the polypeptide is DNA."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 21, wherein the polypeptide is RNA."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 21, wherein the polypeptide is siRNA, shRNA, antisense RNA, or a polypeptide encoding a protein or peptide."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 24, wherein the polypeptide is a polypeptide encoding a protein or peptide."],"number":25,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}