{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"090-300-526-408-887","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"090-300-526-408-887","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8906,"type":"PATENT","title":"Univ Pennsylvania Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":24238,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8221,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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an anti-CD3 antibody loaded onto a human Fcγ receptor, wherein said human Fcγ receptor is expressed from an expression vector in said engineered K562 cell;\n
a ligand for CD28, wherein said ligand for CD28 is selected from the group consisting of anti-CD28 antibody, CD80, and CD86, and wherein said ligand for CD28 is capable of cross-linking CD28 on T cells and delivering a secondary signal to said T cells; and\n
wherein said K562 cell is further genetically modified to express the co-stimulatory molecule, 4-1BBL."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said human Fcγ receptor comprises CD32."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said K562 has been modified to express a cytokine."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 3 wherein said cytokine is selected from the group consisting of IL-2, GM-CSF, IL-4, TNF-α, and IFN-γ."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said T cells comprise CD4+ T cells."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The engineered K562 cell of claim 1 wherein said T cells comprise CD8+ T cells."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said T cells comprise regulatory T cells."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said ligand for CD28 is an anti-CD28 antibody, wherein said anti-CD28 antibody is loaded onto said human Fcγ receptor."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 further comprising an antigen."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 9 wherein said antigen is selected from the group consisting of a tumor antigen, a bacterial antigen, a fungal antigen, a viral antigen, and an autoantigen."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1 wherein said ligand for CD28 is expressed from an expression vector in said engineered mammalian cell and is selected from the group consisting of CD80 and CD86."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The K562 cell of claim 1, wherein said ligand for CD28 is anti-CD28 antibody and said co-stimulatory molecule is 4-1BBL, further wherein said K562 cell induces T cells to remain in exponential growth after a third round of stimulation with said K562 cell."],"number":12,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}